High-fidelity discrete modeling of the HPA axis: a study of regulatory plasticity in biology

The hypothalamic-pituitary-adrenal (HPA) axis is a central regulator of stress response and its dysfunction has been associated with a broad range of complex illnesses including Gulf War Illness (GWI) and Chronic Fatigue Syndrome (CFS). Though classical mathematical approaches have been used to mode...

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Veröffentlicht in:	BMC systems biology 2018-07, Vol.12 (1), p.76-76, Article 76
Hauptverfasser:	Sedghamiz, Hooman, Morris, Matthew, Craddock, Travis J A, Whitley, Darrell, Broderick, Gordon
Format:	Artikel
Sprache:	eng
Schlagworte:	Attractors (mathematics) Bioinformatics Cell cycle Chronic fatigue syndrome Chronic illnesses Circadian rhythms Computer simulation Cortisol Differential equations Fatigue Genetic aspects Glucocorticoids Gulf War Gulf War syndrome Hormones Hypothalamic-pituitary-adrenal axis Hypothalamus Illnesses Logic Mathematical models Migration Neuroplasticity Ordinary differential equations Parameter estimation Persian Gulf War Physiological aspects Physiology Pituitary Plastic properties Plasticity Topology Viral infections
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