Catalytic iron-carbene intermediate revealed in a cytochrome c carbene transferase

Recently, heme proteins have been discovered and engineered by directed evolution to catalyze chemical transformations that are biochemically unprecedented. Many of these nonnatural enzyme-catalyzed reactions are assumed to proceed through a catalytic iron porphyrin carbene (IPC) intermediate, altho...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2018-07, Vol.115 (28), p.7308-7313
Hauptverfasser:	Lewis, Russell D., Garcia-Borràs, Marc, Chalkley, Matthew J., Buller, Andrew R., Houk, K. N., Kan, S. B. Jennifer, Arnold, Frances H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Bacterial Proteins - chemistry Bacterial Proteins - genetics Bacterial Proteins - metabolism Biological Sciences Biosynthesis Catalysis Chemical reactions Computation Computer applications Crystal structure Crystallography Crystallography, X-Ray Cytochrome Cytochrome c Cytochromes Directed evolution Directed Molecular Evolution Electron states Electron transfer Evolution Heme proteins Iron Iron catalysts Methane - analogs & derivatives Methane - chemistry Methane - metabolism Organic chemistry Porphyrins - chemistry Porphyrins - genetics Porphyrins - metabolism Protein synthesis Proteins Rhodothermus - enzymology Rhodothermus - genetics Stereoselectivity Transferases - chemistry Transferases - genetics Transferases - metabolism
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