Muscle metaboreflex-induced vasoconstriction in the ischemic active muscle is exaggerated in heart failure

When oxygen delivery to active muscle is insufficient to meet the metabolic demand during exercise, metabolites accumulate and stimulate skeletal muscle afferents, inducing a reflex increase in blood pressure, termed the muscle metaboreflex. In healthy individuals, muscle metaboreflex activation (MM...

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Veröffentlicht in:	American journal of physiology. Heart and circulatory physiology 2018-01, Vol.314 (1), p.H11-H18
Hauptverfasser:	Kaur, Jasdeep, Senador, Danielle, Krishnan, Abhinav C, Hanna, Hanna W, Alvarez, Alberto, Machado, Tiago M, O'Leary, Donal S
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Arterial Pressure Blood flow Blood pressure Cardiac Output Disease Models, Animal Dogs Energy Metabolism Exercise Female Femur Heart Heart diseases Heart failure Heart Failure - metabolism Heart Failure - physiopathology Hindlimb Intolerance Ischemia Ischemia - metabolism Ischemia - physiopathology Male Metabolites Muscle Contraction Muscle, Skeletal - blood supply Muscle, Skeletal - innervation Muscle, Skeletal - metabolism Muscles Muscular system Oxygen - blood Polymethyl methacrylate Prazosin Receptors, Adrenergic, alpha-1 - metabolism Reflex Skeletal muscle Vasoconstriction Vasodilation
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