High-serum MMP-8 levels are associated with decreased survival and systemic inflammation in colorectal cancer

Background Matrix metalloproteinase-8 (MMP-8) is a protease mainly expressed by neutrophils that cleaves numerous substrates, including collagens and cytokines. We have previously shown that serum MMP-8 levels increase in colorectal cancer (CRC) and correlate with distant metastasis. However, short...

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Veröffentlicht in:	British journal of cancer 2018-07, Vol.119 (2), p.213-219
Hauptverfasser:	Sirniö, Päivi, Tuomisto, Anne, Tervahartiala, Taina, Sorsa, Timo, Klintrup, Kai, Karhu, Toni, Herzig, Karl-Heinz, Mäkelä, Jyrki, Karttunen, Tuomo J., Salo, Tuula, Mäkinen, Markus J., Väyrynen, Juha P.
Format:	Artikel
Sprache:	eng
Schlagworte:	631/67/1857 631/67/580 692/4028/67/1504/1885 692/53/2422 Biomedical and Life Sciences Biomedicine C-reactive protein Cancer Research Collagen (type I) Colorectal cancer Colorectal carcinoma Cytokines Drug Resistance Epidemiology Immunohistochemistry Inflammation Interleukin 1 receptor antagonist Interleukin 1 receptors Interleukin 7 Interleukin 8 Invasiveness Leukocytes (neutrophilic) Mast cells Matrix metalloproteinase Metalloproteinase Metastases Mismatch repair Molecular Medicine Neutrophil collagenase Oncology Parameter modification Serum levels Tumors
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