Gold Nanorod-Based Engineered Cardiac Patch for Suture-Free Engraftment by Near IR
Although cardiac patches hold a promise for repairing the infarcted heart, their integration with the myocardium by sutures may cause further damage to the diseased organ. To address this issue, we developed facile and safe, suture-free technology for the attachment of engineered tissues to organs....
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| Veröffentlicht in: | Nano letters 2018-07, Vol.18 (7), p.4069-4073 |
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| creator | Malki, Maayan Fleischer, Sharon Shapira, Assaf Dvir, Tal |
| description | Although cardiac patches hold a promise for repairing the infarcted heart, their integration with the myocardium by sutures may cause further damage to the diseased organ. To address this issue, we developed facile and safe, suture-free technology for the attachment of engineered tissues to organs. Here, nanocomposite scaffolds comprised of albumin electrospun fibers and gold nanorods (AuNRs) were developed. Cardiac cells were seeded within the scaffolds and assembled into a functioning patch. The engineered tissue was then positioned on the myocardium and irradiated with a near IR laser (808 nm). The AuNRs were able to absorb the light and convert it to thermal energy, which locally changed the molecular structure of the fibrous scaffold, and strongly, but safely, attached it to the wall of the heart. Such hybrid biomaterials can be used in the future to integrate any engineered tissue with any defected organs, while minimizing the risk of additional injury for the patient, caused by the conventional stitching methods. |
| doi_str_mv | 10.1021/acs.nanolett.7b04924 |
| format | Article |
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To address this issue, we developed facile and safe, suture-free technology for the attachment of engineered tissues to organs. Here, nanocomposite scaffolds comprised of albumin electrospun fibers and gold nanorods (AuNRs) were developed. Cardiac cells were seeded within the scaffolds and assembled into a functioning patch. The engineered tissue was then positioned on the myocardium and irradiated with a near IR laser (808 nm). The AuNRs were able to absorb the light and convert it to thermal energy, which locally changed the molecular structure of the fibrous scaffold, and strongly, but safely, attached it to the wall of the heart. Such hybrid biomaterials can be used in the future to integrate any engineered tissue with any defected organs, while minimizing the risk of additional injury for the patient, caused by the conventional stitching methods.</description><subject>Albumins - chemistry</subject><subject>Albumins - therapeutic use</subject><subject>Animals</subject><subject>Biocompatible Materials - chemistry</subject><subject>Biocompatible Materials - therapeutic use</subject><subject>Cardiac Surgical Procedures</subject><subject>Disease Models, Animal</subject><subject>Gold - chemistry</subject><subject>Gold - therapeutic use</subject><subject>Heart - physiopathology</subject><subject>Humans</subject><subject>Letter</subject><subject>Myocardial Infarction - pathology</subject><subject>Myocardial Infarction - surgery</subject><subject>Nanocomposites - chemistry</subject><subject>Nanocomposites - therapeutic use</subject><subject>Nanotubes - chemistry</subject><subject>Rats</subject><subject>Sutures - adverse effects</subject><subject>Tissue Engineering</subject><subject>Tissue Scaffolds - chemistry</subject><issn>1530-6984</issn><issn>1530-6992</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kF1PwjAUhhujEUT_gTH9A8PTj23sxkQJIAlBg3rdnHUdjIyVdJsJ_94SPqI3XvXk9H2fNg8h9wz6DDh7RF33K6xsaZqmH6cgEy4vSJeFAoIoSfjleR7IDrmp6zUAJCKEa9LhiYQo5qxLFhNbZnTuOc5mwQvWJqOjallUxjg_DtFlBWr6jo1e0dw6-tE2rTPB2BmzDzrMm42pGpru6Nygo9PFLbnKsazN3fHska_x6HP4GszeJtPh8yxAKZMm4CA154wjN6HhuZCQakiNySCMcSAykXOIY4aQyZQx7Rfo15JrneYRE0L0yNOBu23Tjcm0_4XDUm1dsUG3UxYL9femKlZqab9VBDIOGfMAeQBoZ-vamfzcZaD2jpV3rE6O1dGxrz38fvdcOkn1ATgE9vW1bV3lNfzP_AGGeYzl</recordid><startdate>20180711</startdate><enddate>20180711</enddate><creator>Malki, Maayan</creator><creator>Fleischer, Sharon</creator><creator>Shapira, Assaf</creator><creator>Dvir, Tal</creator><general>American Chemical Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-3153-9928</orcidid></search><sort><creationdate>20180711</creationdate><title>Gold Nanorod-Based Engineered Cardiac Patch for Suture-Free Engraftment by Near IR</title><author>Malki, Maayan ; Fleischer, Sharon ; Shapira, Assaf ; Dvir, Tal</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a449t-204c2212a2e5e2f340bc0beed057a83d3f20771a0d4b11c3d3aa8342ccbf61333</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Albumins - chemistry</topic><topic>Albumins - therapeutic use</topic><topic>Animals</topic><topic>Biocompatible Materials - chemistry</topic><topic>Biocompatible Materials - therapeutic use</topic><topic>Cardiac Surgical Procedures</topic><topic>Disease Models, Animal</topic><topic>Gold - chemistry</topic><topic>Gold - therapeutic use</topic><topic>Heart - physiopathology</topic><topic>Humans</topic><topic>Letter</topic><topic>Myocardial Infarction - pathology</topic><topic>Myocardial Infarction - surgery</topic><topic>Nanocomposites - chemistry</topic><topic>Nanocomposites - therapeutic use</topic><topic>Nanotubes - chemistry</topic><topic>Rats</topic><topic>Sutures - adverse effects</topic><topic>Tissue Engineering</topic><topic>Tissue Scaffolds - chemistry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Malki, Maayan</creatorcontrib><creatorcontrib>Fleischer, Sharon</creatorcontrib><creatorcontrib>Shapira, Assaf</creatorcontrib><creatorcontrib>Dvir, Tal</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Nano letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Malki, Maayan</au><au>Fleischer, Sharon</au><au>Shapira, Assaf</au><au>Dvir, Tal</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Gold Nanorod-Based Engineered Cardiac Patch for Suture-Free Engraftment by Near IR</atitle><jtitle>Nano letters</jtitle><addtitle>Nano Lett</addtitle><date>2018-07-11</date><risdate>2018</risdate><volume>18</volume><issue>7</issue><spage>4069</spage><epage>4073</epage><pages>4069-4073</pages><issn>1530-6984</issn><eissn>1530-6992</eissn><abstract>Although cardiac patches hold a promise for repairing the infarcted heart, their integration with the myocardium by sutures may cause further damage to the diseased organ. 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| source | MEDLINE; American Chemical Society Journals |
| subjects | Albumins - chemistry Albumins - therapeutic use Animals Biocompatible Materials - chemistry Biocompatible Materials - therapeutic use Cardiac Surgical Procedures Disease Models, Animal Gold - chemistry Gold - therapeutic use Heart - physiopathology Humans Letter Myocardial Infarction - pathology Myocardial Infarction - surgery Nanocomposites - chemistry Nanocomposites - therapeutic use Nanotubes - chemistry Rats Sutures - adverse effects Tissue Engineering Tissue Scaffolds - chemistry |
| title | Gold Nanorod-Based Engineered Cardiac Patch for Suture-Free Engraftment by Near IR |
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