Targeting Tumor Associated Carbonic Anhydrases IX and XII: Highly Isozyme Selective Coumarin and Psoralen Inhibitors

A small library of psoralen carboxylic acids and their corresponding benzenesulfonamide derivatives were designed and synthesized to evaluate their activity and selectivity toward tumor associated human carbonic anhydrase (hCA) isoforms IX and XII. Both psoralen acids and sulfonamides exhibited pote...

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Veröffentlicht in:	ACS medicinal chemistry letters 2018-07, Vol.9 (7), p.725-729
Hauptverfasser:	Melis, Claudia, Distinto, Simona, Bianco, Giulia, Meleddu, Rita, Cottiglia, Filippo, Fois, Benedetta, Taverna, Domenico, Angius, Rossella, Alcaro, Stefano, Ortuso, Francesco, Gaspari, Marco, Angeli, Andrea, Del Prete, Sonia, Capasso, Clemente, Supuran, Claudiu T., Maccioni, Elias
Format:	Artikel
Sprache:	eng
Schlagworte:	Letter
Online-Zugang:	Volltext
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