A calcium optimum for cytotoxic T lymphocyte and natural killer cell cytotoxicity

Key points Cytotoxic T lymphocytes (CTLs) and natural killer (NK) cells are required to eliminate cancer cells. We analysed the Ca2+ dependence of CTL and NK cell cytotoxicity and found that in particular CTLs have a very low optimum of [Ca2+]i (between 122 and 334 nm) and [Ca2+]o (between 23 and 62...

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Veröffentlicht in:	The Journal of physiology 2018-07, Vol.596 (14), p.2681-2698
Hauptverfasser:	Zhou, Xiao, Friedmann, Kim S., Lyrmann, Hélène, Zhou, Yan, Schoppmeyer, Rouven, Knörck, Arne, Mang, Sebastian, Hoxha, Cora, Angenendt, Adrian, Backes, Christian S., Mangerich, Carmen, Zhao, Renping, Cappello, Sabrina, Schwär, Gertrud, Hässig, Carmen, Neef, Marc, Bufe, Bernd, Zufall, Frank, Kruse, Karsten, Niemeyer, Barbara A., Lis, Annette, Qu, Bin, Kummerow, Carsten, Schwarz, Eva C., Hoth, Markus
Format:	Artikel
Sprache:	eng
Schlagworte:	Calcium (extracellular) Calcium (intracellular) Calcium channels Calcium homeostasis Calcium signalling Cancer cancer cells Cell proliferation cytotoxic immune cells Cytotoxicity Homeostasis killing efficiency Leukocyte migration Lymphocytes T Natural killer cells Orai1 protein Research Paper siRNA Special section: Intracellular calcium signalling T cell receptors Tumor microenvironment Tumors
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