Pharmacokinetics and Pharmacodynamics of Treosulfan in Patients With Thalassemia Major Undergoing Allogeneic Hematopoietic Stem Cell Transplantation

A treosulfan (Treo)‐based conditioning regimen prior to hematopoietic stem cell transplantation (HSCT) has been successfully used in treating hematological malignant and nonmalignant diseases. We report Treo pharmacokinetics (PK) in patients with thalassemia major undergoing HSCT (n = 87), receiving...

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Veröffentlicht in:	Clinical pharmacology and therapeutics 2018-09, Vol.104 (3), p.575-583
Hauptverfasser:	Mohanan, Ezhilpavai, Panetta, John C., Lakshmi, Kavitha M., Edison, Eunice S., Korula, Anu, NA, Fouzia, Abraham, Aby, Viswabandya, Auro, George, Biju, Mathews, Vikram, Srivastava, Alok, Balasubramanian, Poonkuzhali
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult beta-Thalassemia - blood beta-Thalassemia - diagnosis beta-Thalassemia - mortality beta-Thalassemia - surgery Biological Variation, Population Busulfan - administration & dosage Busulfan - adverse effects Busulfan - analogs & derivatives Busulfan - pharmacokinetics Child Child, Preschool Female Graft Rejection - prevention & control Graft Survival - drug effects Hematopoietic Stem Cell Transplantation Humans Infant Male Metabolic Clearance Rate Models, Biological Myeloablative Agonists - administration & dosage Myeloablative Agonists - adverse effects Myeloablative Agonists - pharmacokinetics Nonlinear Dynamics Risk Factors Transplantation Conditioning - adverse effects Transplantation Conditioning - methods Transplantation Conditioning - mortality Treatment Outcome Young Adult
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