GOAL study: clinical and non-clinical predictive factors for achieving glycemic control in people with type 2 diabetes in real clinical practice
ObjectiveThe American Diabetes Association and the European Association for the Study of Diabetes guidelines recommend to individualize treatment targets/strategies in inadequately controlled patients by lifestyle management and glucose-lowering drugs to decrease the burden of diabetes-related compl...
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creator | Al Mansari, Abdulqawi Obeid, Youssef Islam, Najmul Fariduddin, Mohammed Hassoun, Ahmed Djaballah, Khier Malek, Mojtaba Dicker, Dror Chaudhury, Tirthankar |
description | ObjectiveThe American Diabetes Association and the European Association for the Study of Diabetes guidelines recommend to individualize treatment targets/strategies in inadequately controlled patients by lifestyle management and glucose-lowering drugs to decrease the burden of diabetes-related complications. This real-world practice study aimed to assess predictive factors for achieving the glycemic hemoglobin A1c (HbA1c) at 6 months as targeted by the treating physician in adults with type 2 diabetes who required initiation of basal insulin, initiation of bolus insulin, or modification from basal or premixed insulin to new insulin regimen containing insulin glargine and/or insulin glulisine. Research design and methodsThis was an international, multicenter, observational survey with 12-month follow-up time in adults with type 2 diabetes inadequately controlled conducted in 10 developing countries. ResultsOverall, 2704 patients (mean age: 54.6 years, body mass index: 28.7 kg/m2; Caucasian: 46.1%, type 2 diabetes duration: 10.1 years) with poor glycemic control (mean HbA1c: 9.7% (83 mmol/mol), fasting blood glucose: 196.8 mg/dL) were eligible. At 6 months, advanced age, Caucasian ethnicity, shorter type 2 diabetes duration (>10 vs 1 year, p |
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This real-world practice study aimed to assess predictive factors for achieving the glycemic hemoglobin A1c (HbA1c) at 6 months as targeted by the treating physician in adults with type 2 diabetes who required initiation of basal insulin, initiation of bolus insulin, or modification from basal or premixed insulin to new insulin regimen containing insulin glargine and/or insulin glulisine. Research design and methodsThis was an international, multicenter, observational survey with 12-month follow-up time in adults with type 2 diabetes inadequately controlled conducted in 10 developing countries. ResultsOverall, 2704 patients (mean age: 54.6 years, body mass index: 28.7 kg/m2; Caucasian: 46.1%, type 2 diabetes duration: 10.1 years) with poor glycemic control (mean HbA1c: 9.7% (83 mmol/mol), fasting blood glucose: 196.8 mg/dL) were eligible. At 6 months, advanced age, Caucasian ethnicity, shorter type 2 diabetes duration (>10 vs 1 year, p<0.0001), lower baseline HbA1c (≥ 8.5% vs <7%, p<0.0001) and no intake of oral antidiabetic drug (OAD) (none vs 2, p=0.02) were predictive factors for achieving glycemic goal as targeted by the treating physician. Absolute changes in the mean HbA1c of −1.7% and −2% were observed from baseline to 6 and 12 months, respectively. ConclusionsAlong with some well-known predictive factors, this study suggested that early insulin regimen treatment initiation and/or intensification allowed patients to promote glycemic control.</description><identifier>ISSN: 2052-4897</identifier><identifier>EISSN: 2052-4897</identifier><identifier>DOI: 10.1136/bmjdrc-2018-000519</identifier><identifier>PMID: 30023075</identifier><language>eng</language><publisher>England: BMJ Publishing Group LTD</publisher><subject>Cardiovascular disease ; Clinical Care/Education/Nutrition ; Clinical medicine ; Diabetes ; Family physicians ; Glucose ; Glucose monitoring ; Hemoglobin ; Insulin ; Patients ; Physicians</subject><ispartof>BMJ open diabetes research & care, 2018-07, Vol.6 (1), p.e000519-e000519</ispartof><rights>Author(s) (or their employer(s)) 2018. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.</rights><rights>2018 Author(s) (or their employer(s)) 2018. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. This is an Open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ . Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Author(s) (or their employer(s)) 2018. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. 2018</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b468t-bde8d535c40b621f71f4363ecbb1e2500f6f168ba51b48520d227039f54446e83</citedby><cites>FETCH-LOGICAL-b468t-bde8d535c40b621f71f4363ecbb1e2500f6f168ba51b48520d227039f54446e83</cites><orcidid>0000-0002-4496-1511 ; 0000-0001-8546-6245</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://drc.bmj.com/content/6/1/e000519.full.pdf$$EPDF$$P50$$Gbmj$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://drc.bmj.com/content/6/1/e000519.full$$EHTML$$P50$$Gbmj$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,27528,27529,27903,27904,53770,53772,77348,77379</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30023075$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Al Mansari, Abdulqawi</creatorcontrib><creatorcontrib>Obeid, Youssef</creatorcontrib><creatorcontrib>Islam, Najmul</creatorcontrib><creatorcontrib>Fariduddin, Mohammed</creatorcontrib><creatorcontrib>Hassoun, Ahmed</creatorcontrib><creatorcontrib>Djaballah, Khier</creatorcontrib><creatorcontrib>Malek, Mojtaba</creatorcontrib><creatorcontrib>Dicker, Dror</creatorcontrib><creatorcontrib>Chaudhury, Tirthankar</creatorcontrib><title>GOAL study: clinical and non-clinical predictive factors for achieving glycemic control in people with type 2 diabetes in real clinical practice</title><title>BMJ open diabetes research & care</title><addtitle>BMJ Open Diabetes Res Care</addtitle><description>ObjectiveThe American Diabetes Association and the European Association for the Study of Diabetes guidelines recommend to individualize treatment targets/strategies in inadequately controlled patients by lifestyle management and glucose-lowering drugs to decrease the burden of diabetes-related complications. This real-world practice study aimed to assess predictive factors for achieving the glycemic hemoglobin A1c (HbA1c) at 6 months as targeted by the treating physician in adults with type 2 diabetes who required initiation of basal insulin, initiation of bolus insulin, or modification from basal or premixed insulin to new insulin regimen containing insulin glargine and/or insulin glulisine. Research design and methodsThis was an international, multicenter, observational survey with 12-month follow-up time in adults with type 2 diabetes inadequately controlled conducted in 10 developing countries. ResultsOverall, 2704 patients (mean age: 54.6 years, body mass index: 28.7 kg/m2; Caucasian: 46.1%, type 2 diabetes duration: 10.1 years) with poor glycemic control (mean HbA1c: 9.7% (83 mmol/mol), fasting blood glucose: 196.8 mg/dL) were eligible. At 6 months, advanced age, Caucasian ethnicity, shorter type 2 diabetes duration (>10 vs 1 year, p<0.0001), lower baseline HbA1c (≥ 8.5% vs <7%, p<0.0001) and no intake of oral antidiabetic drug (OAD) (none vs 2, p=0.02) were predictive factors for achieving glycemic goal as targeted by the treating physician. Absolute changes in the mean HbA1c of −1.7% and −2% were observed from baseline to 6 and 12 months, respectively. ConclusionsAlong with some well-known predictive factors, this study suggested that early insulin regimen treatment initiation and/or intensification allowed patients to promote glycemic control.</description><subject>Cardiovascular disease</subject><subject>Clinical Care/Education/Nutrition</subject><subject>Clinical medicine</subject><subject>Diabetes</subject><subject>Family physicians</subject><subject>Glucose</subject><subject>Glucose monitoring</subject><subject>Hemoglobin</subject><subject>Insulin</subject><subject>Patients</subject><subject>Physicians</subject><issn>2052-4897</issn><issn>2052-4897</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>9YT</sourceid><sourceid>ACMMV</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNqNkc9u1DAQxiMEolXpC3BAlrhwSfH_OByQqgpapJV6gbNlO5NdrxI72Nmt9i14ZLxKWS2cOHnk-X3fzOirqrcE3xDC5Ec7brvkaoqJqjHGgrQvqkuKBa25apuXZ_VFdZ3ztjBFRpgSr6sLhjFluBGX1a_7x9sVyvOuO3xCbvDBOzMgEzoUYqhPH1OCzrvZ7wH1xs0xZdTHhIzbeNj7sEbr4eBg9A65GOYUB-QDmiBOA6AnP2_QfJgAUdR5Y2GGfGwnKMZnE4qvd_CmetWbIcP183tV_fj65fvdQ716vP92d7uqLZdqrm0HqhNMOI6tpKRvSM-ZZOCsJUAFxr3siVTWCGK5EhR3lDaYtb3gnEtQ7Kr6vPhOOztC56CsbQY9JT-adNDReP13J_iNXse9lpiLhpNi8OHZIMWfO8izHn12MAwmQNxlTXFDiVItaQv6_h90G3cplPMKJVXTMElpoehCuRRzTtCfliFYHzPXS-b6mLleMi-id-dnnCR_Ei5AvQBF_D-GvwGFgbio</recordid><startdate>20180701</startdate><enddate>20180701</enddate><creator>Al Mansari, Abdulqawi</creator><creator>Obeid, Youssef</creator><creator>Islam, Najmul</creator><creator>Fariduddin, Mohammed</creator><creator>Hassoun, Ahmed</creator><creator>Djaballah, Khier</creator><creator>Malek, Mojtaba</creator><creator>Dicker, Dror</creator><creator>Chaudhury, Tirthankar</creator><general>BMJ Publishing Group LTD</general><general>BMJ Publishing Group</general><scope>9YT</scope><scope>ACMMV</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>NAPCQ</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-4496-1511</orcidid><orcidid>https://orcid.org/0000-0001-8546-6245</orcidid></search><sort><creationdate>20180701</creationdate><title>GOAL study: clinical and non-clinical predictive factors for achieving glycemic control in people with type 2 diabetes in real clinical practice</title><author>Al Mansari, Abdulqawi ; Obeid, Youssef ; Islam, Najmul ; Fariduddin, Mohammed ; Hassoun, Ahmed ; Djaballah, Khier ; Malek, Mojtaba ; Dicker, Dror ; Chaudhury, Tirthankar</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b468t-bde8d535c40b621f71f4363ecbb1e2500f6f168ba51b48520d227039f54446e83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Cardiovascular disease</topic><topic>Clinical Care/Education/Nutrition</topic><topic>Clinical medicine</topic><topic>Diabetes</topic><topic>Family physicians</topic><topic>Glucose</topic><topic>Glucose monitoring</topic><topic>Hemoglobin</topic><topic>Insulin</topic><topic>Patients</topic><topic>Physicians</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Al Mansari, Abdulqawi</creatorcontrib><creatorcontrib>Obeid, Youssef</creatorcontrib><creatorcontrib>Islam, Najmul</creatorcontrib><creatorcontrib>Fariduddin, Mohammed</creatorcontrib><creatorcontrib>Hassoun, Ahmed</creatorcontrib><creatorcontrib>Djaballah, Khier</creatorcontrib><creatorcontrib>Malek, Mojtaba</creatorcontrib><creatorcontrib>Dicker, Dror</creatorcontrib><creatorcontrib>Chaudhury, Tirthankar</creatorcontrib><collection>BMJ Open Access Journals</collection><collection>BMJ Journals:Open Access</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>ProQuest Nursing and Allied Health Journals</collection><collection>ProQuest_Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Nursing & Allied Health Premium</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>BMJ open diabetes research & care</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Al Mansari, Abdulqawi</au><au>Obeid, Youssef</au><au>Islam, Najmul</au><au>Fariduddin, Mohammed</au><au>Hassoun, Ahmed</au><au>Djaballah, Khier</au><au>Malek, Mojtaba</au><au>Dicker, Dror</au><au>Chaudhury, Tirthankar</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>GOAL study: clinical and non-clinical predictive factors for achieving glycemic control in people with type 2 diabetes in real clinical practice</atitle><jtitle>BMJ open diabetes research & care</jtitle><addtitle>BMJ Open Diabetes Res Care</addtitle><date>2018-07-01</date><risdate>2018</risdate><volume>6</volume><issue>1</issue><spage>e000519</spage><epage>e000519</epage><pages>e000519-e000519</pages><issn>2052-4897</issn><eissn>2052-4897</eissn><abstract>ObjectiveThe American Diabetes Association and the European Association for the Study of Diabetes guidelines recommend to individualize treatment targets/strategies in inadequately controlled patients by lifestyle management and glucose-lowering drugs to decrease the burden of diabetes-related complications. This real-world practice study aimed to assess predictive factors for achieving the glycemic hemoglobin A1c (HbA1c) at 6 months as targeted by the treating physician in adults with type 2 diabetes who required initiation of basal insulin, initiation of bolus insulin, or modification from basal or premixed insulin to new insulin regimen containing insulin glargine and/or insulin glulisine. Research design and methodsThis was an international, multicenter, observational survey with 12-month follow-up time in adults with type 2 diabetes inadequately controlled conducted in 10 developing countries. ResultsOverall, 2704 patients (mean age: 54.6 years, body mass index: 28.7 kg/m2; Caucasian: 46.1%, type 2 diabetes duration: 10.1 years) with poor glycemic control (mean HbA1c: 9.7% (83 mmol/mol), fasting blood glucose: 196.8 mg/dL) were eligible. At 6 months, advanced age, Caucasian ethnicity, shorter type 2 diabetes duration (>10 vs 1 year, p<0.0001), lower baseline HbA1c (≥ 8.5% vs <7%, p<0.0001) and no intake of oral antidiabetic drug (OAD) (none vs 2, p=0.02) were predictive factors for achieving glycemic goal as targeted by the treating physician. Absolute changes in the mean HbA1c of −1.7% and −2% were observed from baseline to 6 and 12 months, respectively. ConclusionsAlong with some well-known predictive factors, this study suggested that early insulin regimen treatment initiation and/or intensification allowed patients to promote glycemic control.</abstract><cop>England</cop><pub>BMJ Publishing Group LTD</pub><pmid>30023075</pmid><doi>10.1136/bmjdrc-2018-000519</doi><orcidid>https://orcid.org/0000-0002-4496-1511</orcidid><orcidid>https://orcid.org/0000-0001-8546-6245</orcidid><oa>free_for_read</oa></addata></record> |
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subjects | Cardiovascular disease Clinical Care/Education/Nutrition Clinical medicine Diabetes Family physicians Glucose Glucose monitoring Hemoglobin Insulin Patients Physicians |
title | GOAL study: clinical and non-clinical predictive factors for achieving glycemic control in people with type 2 diabetes in real clinical practice |
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