Novel Interplay Between Smad1 and Smad3 Phosphorylation via AGE Regulates the Progression of Diabetic Nephropathy

Diabetic nephropathy (DN) is the major cause of end-stage renal failure and is associated with increased morbidity and mortality compared with other causes of renal diseases. We previously found that Smad1 plays a critical role in the development of DN both in vitro and in vivo . However, functional...

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Veröffentlicht in:	Scientific reports 2018-07, Vol.8 (1), p.10548-14, Article 10548
Hauptverfasser:	Ono, Hiroyuki, Abe, Hideharu, Sakurai, Akiko, Ochi, Arisa, Tominaga, Tatsuya, Tamaki, Masanori, Kishi, Seiji, Murakami, Taichi, Nagai, Kojiro, Kohashi, Masayuki, Doi, Toshio
Format:	Artikel
Sprache:	eng
Schlagworte:	13/1 13/109 13/51 38/23 38/70 38/77 631/337 631/80 64/60 82/80 Diabetes Diabetes mellitus Diabetic nephropathy End-stage renal disease Extracellular matrix Glycosylation Humanities and Social Sciences Kidney diseases Kinases Mesangial cells Molecular modelling Morbidity multidisciplinary Nephropathy Phosphorylation Renal failure Rodents Science Science (multidisciplinary) Smad3 protein
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