Systematic RNA-interference in primary human monocyte-derived macrophages: A high-throughput platform to study foam cell formation

Macrophage-derived foam cells are key regulators of atherogenesis. They accumulate in atherosclerotic plaques and support inflammatory processes by producing cytokines and chemokines. Identifying factors that regulate macrophage lipid uptake may reveal therapeutic targets for coronary artery disease...

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Veröffentlicht in:	Scientific reports 2018-07, Vol.8 (1), p.10516-11, Article 10516
Hauptverfasser:	Domschke, Gabriele, Linden, Fabian, Pawig, Lukas, Hafner, Anna, Akhavanpoor, Mohammadreza, Reymann, Jürgen, Doesch, Andreas O., Erbel, Christian, Weber, Christian, Katus, Hugo A., Noels, Heidi, Erfle, Holger, Gleissner, Christian A., Runz, Heiko
Format:	Artikel
Sprache:	eng
Schlagworte:	13 13/89 14 14/63 42 42/47 631/1647/2163 631/208/505 692/308/1426 96 96/34 Arteriosclerosis Atherogenesis Cardiovascular disease Chemokines Coronary artery CXCL12 protein CXCR4 protein Cytokines Gene silencing Heart diseases High-throughput screening Humanities and Social Sciences Image processing Inflammation Low density lipoprotein Macrophages Monocytes multidisciplinary Peripheral blood Plaques Ribonucleic acid RNA RNA-mediated interference Science Science (multidisciplinary) Signal transduction siRNA Therapeutic applications
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