Imaging ERK and PKA Activation in Single Dendritic Spines during Structural Plasticity

Extracellular signal-regulated kinase (ERK) and protein kinase A (PKA) play important roles in LTP and spine structural plasticity. While fluorescence resonance energy transfer (FRET)-based sensors for these kinases had previously been developed, they did not provide sufficient sensitivity for imagi...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Neuron (Cambridge, Mass.) Mass.), 2017-03, Vol.93 (6), p.1315-1324.e3
Hauptverfasser:	Tang, Shen, Yasuda, Ryohei
Format:	Artikel
Sprache:	eng
Schlagworte:	A kinase-anchoring protein Actin Adenosine kinase Amino acid sequence Animals Biosensors Brain slice preparation CA1 Region, Hippocampal - metabolism Calcium influx Calcium signalling Cell activation Cells, Cultured Cerebellum Circular dichroism Cyclic AMP Cyclic AMP-Dependent Protein Kinases - metabolism Dendrites Dendritic Spines - enzymology Dendritic Spines - physiology Electrical stimuli Epidermal growth factor Extracellular Signal-Regulated MAP Kinases - metabolism Female FLIM Fluorescence Resonance Energy Transfer - methods FRET Hippocampus Humans kinase Kinases Long-term depression Long-term potentiation Long-Term Potentiation - physiology LTP Male Mice Microscopy, Fluorescence, Multiphoton Mutation Neuronal Plasticity - physiology Neurons Phosphorylation Protein kinase Proteins Pyramidal Cells - metabolism Rodents Sensors Signal transduction signaling synaptic plasticity Transcription factors α-Amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!