A noncanonical PPARγ/RXRα-binding sequence regulates leptin expression in response to changes in adipose tissue mass

Leptin expression decreases after fat loss and is increased when obesity develops, and its proper quantitative regulation is essential for the homeostatic control of fat mass. We previously reported that a distant leptin enhancer 1 (LE1), 16 kb upstream from the transcription start site (TSS), confe...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2018-06, Vol.115 (26), p.E6039-E6047
Hauptverfasser:	Zhang, Yinxin, Dallner, Olof Stefan, Nakadai, Tomoyoshi, Fayzikhodjaeva, Gulya, Lu, Yi-Hsueh, Lazar, Mitchell A., Roeder, Robert G., Friedman, Jeffrey M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological Sciences PNAS Plus
Online-Zugang:	Volltext
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