Saphenous graft atherosclerosis as assessed by optical coherence tomography data for stenotic and non-stenotic lesions from the OCTOPUS registry
Coronary artery bypass grafting (CABG), although widely used for a long time in diffuse coronary artery disease (CAD), has serious limitations associated with graft aging and its degeneration. The relationship between saphenous vein graft (SVG) plaque morphology assessed by optical coherence tomogra...
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| creator | Kubiak, Grzegorz M Pociask, Elżbieta Wańha, Wojciech Dobrolińska, Magdalena Gąsior, Paweł Smolka, Grzegorz Ochała, Andrzej Gąsior, Zbigniew Wojakowski, Wojciech Roleder, Tomasz |
| description | Coronary artery bypass grafting (CABG), although widely used for a long time in diffuse coronary artery disease (CAD), has serious limitations associated with graft aging and its degeneration.
The relationship between saphenous vein graft (SVG) plaque morphology assessed by optical coherence tomography (OCT) and clinical findings has not been elucidated yet.
We compared the morphology of SVG in stenotic vs. non-stenotic lesions using OCT imaging in 29 patients hospitalized in our center within the OCTOPUS registry.
Stenotic lesions were characterized by higher incidence of thin-cap fibroatheroma (TCFA) (33% vs. 0%,
= 0.0048), thrombus (28% vs. 0%,
= 0.0008), lipid-rich plaque (LRP) (75% vs. 35%,
= 0.0013) and plaque within the SVG valve (19% vs. 0%,
= 0.0114) as compared to non-stenotic lesions. Patients with intimal tearing or rupture (ITR) were older (75.8% vs. 68.9 years,
= 0.047) and had lower left ventricular ejection fraction (LVEF) (32.0% vs. 49.7%,
= 0.001) and glomerular filtration rate (GFR) (36.0 vs. 73.6 ml/min/1.73 m
,
= 0.010). Patients with calcified lesions vs. those without had lower high-density lipoprotein (HDL) cholesterol (33.2 vs. 44.1 mg/dl,
= 0.018), similarly to those with ruptured plaque vs. those without (28.3 vs. 41.7 mg/dl,
= 0.047).
Presence of ITR was associated with advanced age, decreased LVEF and renal insufficiency. Decreased concentration of HDL was associated with higher occurrence of calcified and ruptured plaque. |
| doi_str_mv | 10.5114/aic.2018.76407 |
| format | Article |
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The relationship between saphenous vein graft (SVG) plaque morphology assessed by optical coherence tomography (OCT) and clinical findings has not been elucidated yet.
We compared the morphology of SVG in stenotic vs. non-stenotic lesions using OCT imaging in 29 patients hospitalized in our center within the OCTOPUS registry.
Stenotic lesions were characterized by higher incidence of thin-cap fibroatheroma (TCFA) (33% vs. 0%,
= 0.0048), thrombus (28% vs. 0%,
= 0.0008), lipid-rich plaque (LRP) (75% vs. 35%,
= 0.0013) and plaque within the SVG valve (19% vs. 0%,
= 0.0114) as compared to non-stenotic lesions. Patients with intimal tearing or rupture (ITR) were older (75.8% vs. 68.9 years,
= 0.047) and had lower left ventricular ejection fraction (LVEF) (32.0% vs. 49.7%,
= 0.001) and glomerular filtration rate (GFR) (36.0 vs. 73.6 ml/min/1.73 m
,
= 0.010). Patients with calcified lesions vs. those without had lower high-density lipoprotein (HDL) cholesterol (33.2 vs. 44.1 mg/dl,
= 0.018), similarly to those with ruptured plaque vs. those without (28.3 vs. 41.7 mg/dl,
= 0.047).
Presence of ITR was associated with advanced age, decreased LVEF and renal insufficiency. Decreased concentration of HDL was associated with higher occurrence of calcified and ruptured plaque.</description><identifier>ISSN: 1734-9338</identifier><identifier>EISSN: 1897-4295</identifier><identifier>DOI: 10.5114/aic.2018.76407</identifier><identifier>PMID: 30008768</identifier><language>eng</language><publisher>Poland: Termedia Publishing House</publisher><subject>Atherosclerosis ; Calcification ; Cardiovascular disease ; Coronary vessels ; Ejection fraction ; Morphology ; Original Paper ; Tomography</subject><ispartof>Postępy w kardiologii interwencyjnej, 2018-01, Vol.14 (2), p.157-166</ispartof><rights>2018. This work is published under http://creativecommons.org/licenses/by-nc-sa/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Copyright: © 2018 Termedia Sp. z o. o. 2018</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c418t-f013834ca942ee663f8dcc4d9c0bae520a3cc1c5db1df8d1056eaa9d253779343</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6041839/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6041839/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30008768$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kubiak, Grzegorz M</creatorcontrib><creatorcontrib>Pociask, Elżbieta</creatorcontrib><creatorcontrib>Wańha, Wojciech</creatorcontrib><creatorcontrib>Dobrolińska, Magdalena</creatorcontrib><creatorcontrib>Gąsior, Paweł</creatorcontrib><creatorcontrib>Smolka, Grzegorz</creatorcontrib><creatorcontrib>Ochała, Andrzej</creatorcontrib><creatorcontrib>Gąsior, Zbigniew</creatorcontrib><creatorcontrib>Wojakowski, Wojciech</creatorcontrib><creatorcontrib>Roleder, Tomasz</creatorcontrib><title>Saphenous graft atherosclerosis as assessed by optical coherence tomography data for stenotic and non-stenotic lesions from the OCTOPUS registry</title><title>Postępy w kardiologii interwencyjnej</title><addtitle>Postepy Kardiol Interwencyjnej</addtitle><description>Coronary artery bypass grafting (CABG), although widely used for a long time in diffuse coronary artery disease (CAD), has serious limitations associated with graft aging and its degeneration.
The relationship between saphenous vein graft (SVG) plaque morphology assessed by optical coherence tomography (OCT) and clinical findings has not been elucidated yet.
We compared the morphology of SVG in stenotic vs. non-stenotic lesions using OCT imaging in 29 patients hospitalized in our center within the OCTOPUS registry.
Stenotic lesions were characterized by higher incidence of thin-cap fibroatheroma (TCFA) (33% vs. 0%,
= 0.0048), thrombus (28% vs. 0%,
= 0.0008), lipid-rich plaque (LRP) (75% vs. 35%,
= 0.0013) and plaque within the SVG valve (19% vs. 0%,
= 0.0114) as compared to non-stenotic lesions. Patients with intimal tearing or rupture (ITR) were older (75.8% vs. 68.9 years,
= 0.047) and had lower left ventricular ejection fraction (LVEF) (32.0% vs. 49.7%,
= 0.001) and glomerular filtration rate (GFR) (36.0 vs. 73.6 ml/min/1.73 m
,
= 0.010). Patients with calcified lesions vs. those without had lower high-density lipoprotein (HDL) cholesterol (33.2 vs. 44.1 mg/dl,
= 0.018), similarly to those with ruptured plaque vs. those without (28.3 vs. 41.7 mg/dl,
= 0.047).
Presence of ITR was associated with advanced age, decreased LVEF and renal insufficiency. Decreased concentration of HDL was associated with higher occurrence of calcified and ruptured plaque.</description><subject>Atherosclerosis</subject><subject>Calcification</subject><subject>Cardiovascular disease</subject><subject>Coronary vessels</subject><subject>Ejection fraction</subject><subject>Morphology</subject><subject>Original Paper</subject><subject>Tomography</subject><issn>1734-9338</issn><issn>1897-4295</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNpdkVFvFCEQx4nR2Fp99dGQ-OLLnrCwC7yYmItVkyZn0vaZzAF7R7MLK3BN7lv4kWXbelGTCRDmN3-G-SP0lpJVRyn_CN6sWkLlSvSciGfonEolGt6q7nk9C8YbxZg8Q69yviOkE0zRl-iMEUKk6OU5-nUN896FeMh4l2AoGMrepZjNuKw-Y1giuxoWb484zsUbGLGJFXPBOFziFGvpvD9iCwXwEBPOpUpWEEOwOMTQnC5Gl30MGQ8pTrg-hTfrm82P22uc3M7nko6v0YsBxuzePO0X6Pbyy836W3O1-fp9_fmqMZzK0gyEMsm4AcVb5_qeDdIaw60yZAuuawkwY6jp7JbamqKk6x2Asm3HhFCMswv06VF3PmwnZ40LJcGo5-QnSEcdwet_M8Hv9S7e657UBpiqAh-eBFL8eXC56Mln48YRgqvj1C0RRJKO8a6i7_9D7-Ihhfq9hVKKKyaWjlaPlKmTz8kNp2Yo0YvZupqtF7P1g9m14N3fXzjhf9xlvwGzYqm1</recordid><startdate>20180101</startdate><enddate>20180101</enddate><creator>Kubiak, Grzegorz M</creator><creator>Pociask, Elżbieta</creator><creator>Wańha, Wojciech</creator><creator>Dobrolińska, Magdalena</creator><creator>Gąsior, Paweł</creator><creator>Smolka, Grzegorz</creator><creator>Ochała, Andrzej</creator><creator>Gąsior, Zbigniew</creator><creator>Wojakowski, Wojciech</creator><creator>Roleder, Tomasz</creator><general>Termedia Publishing House</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BYOGL</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20180101</creationdate><title>Saphenous graft atherosclerosis as assessed by optical coherence tomography data for stenotic and non-stenotic lesions from the OCTOPUS registry</title><author>Kubiak, Grzegorz M ; Pociask, Elżbieta ; Wańha, Wojciech ; Dobrolińska, Magdalena ; Gąsior, Paweł ; Smolka, Grzegorz ; Ochała, Andrzej ; Gąsior, Zbigniew ; Wojakowski, Wojciech ; Roleder, Tomasz</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c418t-f013834ca942ee663f8dcc4d9c0bae520a3cc1c5db1df8d1056eaa9d253779343</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Atherosclerosis</topic><topic>Calcification</topic><topic>Cardiovascular disease</topic><topic>Coronary vessels</topic><topic>Ejection fraction</topic><topic>Morphology</topic><topic>Original Paper</topic><topic>Tomography</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kubiak, Grzegorz M</creatorcontrib><creatorcontrib>Pociask, Elżbieta</creatorcontrib><creatorcontrib>Wańha, Wojciech</creatorcontrib><creatorcontrib>Dobrolińska, Magdalena</creatorcontrib><creatorcontrib>Gąsior, Paweł</creatorcontrib><creatorcontrib>Smolka, Grzegorz</creatorcontrib><creatorcontrib>Ochała, Andrzej</creatorcontrib><creatorcontrib>Gąsior, Zbigniew</creatorcontrib><creatorcontrib>Wojakowski, Wojciech</creatorcontrib><creatorcontrib>Roleder, Tomasz</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>East Europe, Central Europe Database</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Access via ProQuest (Open Access)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Postępy w kardiologii interwencyjnej</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kubiak, Grzegorz M</au><au>Pociask, Elżbieta</au><au>Wańha, Wojciech</au><au>Dobrolińska, Magdalena</au><au>Gąsior, Paweł</au><au>Smolka, Grzegorz</au><au>Ochała, Andrzej</au><au>Gąsior, Zbigniew</au><au>Wojakowski, Wojciech</au><au>Roleder, Tomasz</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Saphenous graft atherosclerosis as assessed by optical coherence tomography data for stenotic and non-stenotic lesions from the OCTOPUS registry</atitle><jtitle>Postępy w kardiologii interwencyjnej</jtitle><addtitle>Postepy Kardiol Interwencyjnej</addtitle><date>2018-01-01</date><risdate>2018</risdate><volume>14</volume><issue>2</issue><spage>157</spage><epage>166</epage><pages>157-166</pages><issn>1734-9338</issn><eissn>1897-4295</eissn><abstract>Coronary artery bypass grafting (CABG), although widely used for a long time in diffuse coronary artery disease (CAD), has serious limitations associated with graft aging and its degeneration.
The relationship between saphenous vein graft (SVG) plaque morphology assessed by optical coherence tomography (OCT) and clinical findings has not been elucidated yet.
We compared the morphology of SVG in stenotic vs. non-stenotic lesions using OCT imaging in 29 patients hospitalized in our center within the OCTOPUS registry.
Stenotic lesions were characterized by higher incidence of thin-cap fibroatheroma (TCFA) (33% vs. 0%,
= 0.0048), thrombus (28% vs. 0%,
= 0.0008), lipid-rich plaque (LRP) (75% vs. 35%,
= 0.0013) and plaque within the SVG valve (19% vs. 0%,
= 0.0114) as compared to non-stenotic lesions. Patients with intimal tearing or rupture (ITR) were older (75.8% vs. 68.9 years,
= 0.047) and had lower left ventricular ejection fraction (LVEF) (32.0% vs. 49.7%,
= 0.001) and glomerular filtration rate (GFR) (36.0 vs. 73.6 ml/min/1.73 m
,
= 0.010). Patients with calcified lesions vs. those without had lower high-density lipoprotein (HDL) cholesterol (33.2 vs. 44.1 mg/dl,
= 0.018), similarly to those with ruptured plaque vs. those without (28.3 vs. 41.7 mg/dl,
= 0.047).
Presence of ITR was associated with advanced age, decreased LVEF and renal insufficiency. Decreased concentration of HDL was associated with higher occurrence of calcified and ruptured plaque.</abstract><cop>Poland</cop><pub>Termedia Publishing House</pub><pmid>30008768</pmid><doi>10.5114/aic.2018.76407</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| source | DOAJ Directory of Open Access Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central; PubMed Central Open Access |
| subjects | Atherosclerosis Calcification Cardiovascular disease Coronary vessels Ejection fraction Morphology Original Paper Tomography |
| title | Saphenous graft atherosclerosis as assessed by optical coherence tomography data for stenotic and non-stenotic lesions from the OCTOPUS registry |
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