Exosomal secretion of α-synuclein as protective mechanism after upstream blockage of macroautophagy

Accumulation of pathological α-synuclein aggregates plays a major role in Parkinson’s disease. Macroautophagy is a mechanism to degrade intracellular protein aggregates by wrapping them into autophagosomes, followed by fusion with lysosomes. We had previously shown that pharmacological activation of...

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Veröffentlicht in:	Cell death & disease 2018-07, Vol.9 (7), p.757-14, Article 757
Hauptverfasser:	Fussi, Natascha, Höllerhage, Matthias, Chakroun, Tasnim, Nykänen, Niko-Petteri, Rösler, Thomas W., Koeglsperger, Thomas, Wurst, Wolfgang, Behrends, Christian, Höglinger, Günter U.
Format:	Artikel
Sprache:	eng
Schlagworte:	13/109 82/29 Antibodies Apoptosis Autophagy Biochemistry Biomedical and Life Sciences Cell Biology Cell Culture Cell death Exosomes Immunology Intracellular Life Sciences Lysosomes Phagocytosis Phagosomes Proteasomes Protein folding Secretion Synuclein Toxicity Ubiquitin
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