Zika Virus Envelope Protein induces G2/M Cell Cycle Arrest and Apoptosis via an Intrinsic Cell Death Signaling Pathway in Neuroendocrine PC12 Cells

Clinical evidence suggests that there exists a strong correlation between Zika virus (ZIKV) infection and abnormal development of the nervous system. However, the underlying mechanisms remain to be elusive. In this study, recombinant lentiviral vectors coding for ZIKV structural proteins and truncat...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	International journal of biological sciences 2018-01, Vol.14 (9), p.1099-1108
Hauptverfasser:	Liu, Jun, Li, Qingqing, Li, Xiaoxin, Qiu, Zhenzhen, Li, Andrew, Liang, Wenhan, Chen, Huangyao, Cai, Xiangsheng, Chen, Xinglu, Duan, Xinyue, Li, Jingjing, Wu, Wangsheng, Xu, Mingyu, Mao, Yingying, Chen, Huiying, Li, Jinlong, Gu, Weiwang, Li, Hongwei
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Apoptosis - genetics Apoptosis - physiology Bax protein Bcl-2 protein bcl-2-Associated X Protein - genetics bcl-2-Associated X Protein - metabolism Caspase Caspase 3 - genetics Caspase 3 - metabolism Caspase 9 - genetics Caspase 9 - metabolism Caspase-3 Caspase-9 Cell cycle Cell Cycle Checkpoints - genetics Cell Cycle Checkpoints - physiology Cell death Cell proliferation Coding Cyclin B1 Cyclin-dependent kinase inhibitor p21 Cyclin-Dependent Kinase Inhibitor p21 - genetics Cyclin-Dependent Kinase Inhibitor p21 - metabolism Data processing Flow cytometry Genetic Vectors - genetics Immunofluorescence Lentivirus - genetics Mortality Nervous system p53 Protein PC12 Cells Pheochromocytoma cells Proteins Proto-Oncogene Proteins c-bcl-2 - genetics Proto-Oncogene Proteins c-bcl-2 - metabolism Rats Research Paper Signal transduction Signal Transduction - genetics Signal Transduction - physiology Signaling Structural proteins Tumor Suppressor Protein p53 - genetics Tumor Suppressor Protein p53 - metabolism Vector-borne diseases Viral envelope proteins Viral Envelope Proteins - genetics Viral Envelope Proteins - metabolism Viral Envelope Proteins - physiology Viruses Zika virus Zika Virus - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!