Repair of DNA double-strand breaks by mammalian alternative end-joining pathways
Alternative end-joining (a-EJ) pathways, which repair DNA double-strand breaks (DSBs), are initiated by end resection that generates 3′ single strands. This reaction is shared, at least in part, with homologous recombination but distinguishes a-EJ from the major nonhomologous end-joining pathway. Al...
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| Veröffentlicht in: | The Journal of biological chemistry 2018-07, Vol.293 (27), p.10536-10546 |
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| container_title | The Journal of biological chemistry |
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| creator | Sallmyr, Annahita Tomkinson, Alan E. |
| description | Alternative end-joining (a-EJ) pathways, which repair DNA double-strand breaks (DSBs), are initiated by end resection that generates 3′ single strands. This reaction is shared, at least in part, with homologous recombination but distinguishes a-EJ from the major nonhomologous end-joining pathway. Although the a-EJ pathways make only a minor and poorly understood contribution to DSB repair in nonmalignant cells, there is growing interest in these pathways, as they generate genomic rearrangements that are hallmarks of cancer cells. Here, we review and discuss the current understanding of the mechanisms and regulation of a-EJ pathways, the role of a-EJ in human disease, and the potential utility of a-EJ as a therapeutic target in cancer. |
| doi_str_mv | 10.1074/jbc.TM117.000375 |
| format | Article |
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This reaction is shared, at least in part, with homologous recombination but distinguishes a-EJ from the major nonhomologous end-joining pathway. Although the a-EJ pathways make only a minor and poorly understood contribution to DSB repair in nonmalignant cells, there is growing interest in these pathways, as they generate genomic rearrangements that are hallmarks of cancer cells. 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| subjects | alternative end-joining pathway Animals chromosomes deletions Disease - genetics DNA Breaks, Double-Stranded DNA damage DNA End-Joining Repair DNA endonuclease DNA ligation DNA polymerase double-strand break genomic instability Homologous Recombination Humans microhomology Signal Transduction single-strand annealing Thematic Minireviews translocation |
| title | Repair of DNA double-strand breaks by mammalian alternative end-joining pathways |
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