Usp25m protease regulates ubiquitin-like processing of TUG proteins to control GLUT4 glucose transporter translocation in adipocytes

Insulin stimulates the exocytic translocation of specialized vesicles in adipocytes, which inserts GLUT4 glucose transporters into the plasma membrane to enhance glucose uptake. Previous results support a model in which TUG (Tether containing a UBX domain for GLUT4) proteins trap these GLUT4 storage...

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Veröffentlicht in:	The Journal of biological chemistry 2018-07, Vol.293 (27), p.10466-10486
Hauptverfasser:	Habtemichael, Estifanos N., Li, Don T., Alcázar-Román, Abel, Westergaard, Xavier O., Li, Muyi, Petersen, Max C., Li, Hanbing, DeVries, Stephen G., Li, Eric, Julca-Zevallos, Omar, Wolenski, Joseph S., Bogan, Jonathan S.
Format:	Artikel
Sprache:	eng
Schlagworte:	adipocyte Adipocytes - cytology Adipocytes - drug effects Adipocytes - metabolism Animals Carrier Proteins - genetics Carrier Proteins - metabolism Cell Biology Cell Membrane - metabolism Cells, Cultured Glucose - metabolism glucose transporter type 4 (GLUT4) Glucose Transporter Type 4 - genetics Glucose Transporter Type 4 - metabolism Hypoglycemic Agents - pharmacology insulin Insulin - pharmacology insulin resistance Intracellular Signaling Peptides and Proteins kinesin Kinesin - genetics Kinesin - metabolism Male membrane trafficking Mice Mice, Inbred C57BL Motor Activity protein processing protein translocation Protein Transport Proteolysis Rats Rats, Sprague-Dawley Signal Transduction Ubiquitin - metabolism Ubiquitin Thiolesterase - genetics Ubiquitin Thiolesterase - metabolism ubiquitylation (ubiquitination)
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