From the RNA world to the clinic
The study of RNA has continually emphasized the structural and functional versatility of RNA molecules. This versatility has inspired translational and clinical researchers to explore the utility of RNA-based therapeutic agents for a wide variety of medical applications. Several RNA therapeutics, wi...
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| Veröffentlicht in: | Science (American Association for the Advancement of Science) 2016-06, Vol.352 (6292), p.1417-1420 |
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| container_title | Science (American Association for the Advancement of Science) |
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| creator | Sullenger, Bruce A. Nair, Smita |
| description | The study of RNA has continually emphasized the structural and functional versatility of RNA molecules. This versatility has inspired translational and clinical researchers to explore the utility of RNA-based therapeutic agents for a wide variety of medical applications. Several RNA therapeutics, with diverse modes of action, are being evaluated in large late-stage clinical trials, and many more are in early clinical development. Hundreds of patients are enrolled in large trials testing messenger RNAs to combat cancer, small interfering RNAs to treat renal and hepatic disorders, and aptamers to combat ocular and cardiovascular disease. Results from these studies are generating considerable interest among the biomedical community and the public and will be important for the future development of this emerging class of therapeutic agents. |
| doi_str_mv | 10.1126/science.aad8709 |
| format | Article |
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| source | MEDLINE; JSTOR Archive Collection A-Z Listing; American Association for the Advancement of Science |
| subjects | Animals Biological Therapy - methods Cancer Vaccines - genetics Cancer Vaccines - therapeutic use Cellular Reprogramming Techniques Chemical compounds Communities Disorders Heart diseases Humans Immunotherapy - methods Molecular biology Pharmaceutical sciences Pharmacology Protein Biosynthesis Proteins - antagonists & inhibitors REVIEWS Ribonucleic acid Ribonucleic acids RNA RNA, Long Noncoding - genetics RNA, Messenger - genetics RNA, Small Interfering - genetics Utilities Versatility |
| title | From the RNA world to the clinic |
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