Soy germ extract alleviates menopausal hot flushes: placebo-controlled double-blind trial
Background/objectives A double-blind, placebo-controlled study was performed to assess the potency of a soy germ preparation for the alleviation of menopausal hot flushes. Subjects/methods Caucasian women with at least seven hot flushes daily were treated with soy germ extract (100 mg isoflavone gly...
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| Veröffentlicht in: | European journal of clinical nutrition 2018-07, Vol.72 (7), p.961-970 |
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| creator | Imhof, Martin Gocan, Anca Imhof, Marianne Schmidt, Mathias |
| description | Background/objectives
A double-blind, placebo-controlled study was performed to assess the potency of a soy germ preparation for the alleviation of menopausal hot flushes.
Subjects/methods
Caucasian women with at least seven hot flushes daily were treated with soy germ extract (100 mg isoflavone glycosides) daily or with placebo for 12 weeks, followed by 12 weeks of open treatment with soy. Outcome parameters were the number of hot flushes and the evaluation of the Greene Climacteric Scale.
Results
A total of 192 women were included. As the hot flush diaries from one study centre were lost, the assessment of hot flushes was based on 136 participants (soy: 54 women; placebo: 82 women). After 12 weeks, 180 women were available for the analysis of Greene Scale and safety (soy and placebo: each 90 women). Hot flushes were reduced by 43.3% (–3.5 hot flushes) with soy and by 30.8% with placebo (–2.6;
p
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| doi_str_mv | 10.1038/s41430-018-0173-3 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6035149</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2047936647</sourcerecordid><originalsourceid>FETCH-LOGICAL-c470t-bf57a20f39c2b41365ff87566de0482460704bbe75f35094b670024a640fcd2f3</originalsourceid><addsrcrecordid>eNp1kU9rFTEUxYNY7Gv1A7iRgBs3sTf_Z1wIpWgVCi7UhauQZJK-KZnJM5kp9ts35dWqBRfhLs7vntzDQeglhbcUeHdSBRUcCNCuPc0Jf4I2VGhFpBLwFG2gl4JwAH2Ijmq9AmiiZs_QIes70dOObtCPr_kGX4Yy4fBrKdYv2KYUrke7hIqnMOedXatNeJsXHNNat6G-w7tkfXCZ-DwvJTd-wENeXQrEpXEe8FJGm56jg2hTDS_u5zH6_vHDt7NP5OLL-eez0wvihYaFuCi1ZRB575kTlCsZY6elUkMA0TGhQINwLmgZuYReOKUBmLAtYfQDi_wYvd_77lY3hcGHdpNNZlfGyZYbk-1o_lXmcWsu87VRwCUVfTN4c29Q8s811MVMY_UhJTuHvFbDQOieKyV0Q18_Qq_yWuYWr1FK8k5oyhpF95QvudYS4sMxFMxdcWZfnGnFmbviDG87r_5O8bDxu6kGsD1QmzS3xv58_X_XW2wSpBE</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2065384712</pqid></control><display><type>article</type><title>Soy germ extract alleviates menopausal hot flushes: placebo-controlled double-blind trial</title><source>MEDLINE</source><source>SpringerNature Journals</source><creator>Imhof, Martin ; Gocan, Anca ; Imhof, Marianne ; Schmidt, Mathias</creator><creatorcontrib>Imhof, Martin ; Gocan, Anca ; Imhof, Marianne ; Schmidt, Mathias</creatorcontrib><description>Background/objectives
A double-blind, placebo-controlled study was performed to assess the potency of a soy germ preparation for the alleviation of menopausal hot flushes.
Subjects/methods
Caucasian women with at least seven hot flushes daily were treated with soy germ extract (100 mg isoflavone glycosides) daily or with placebo for 12 weeks, followed by 12 weeks of open treatment with soy. Outcome parameters were the number of hot flushes and the evaluation of the Greene Climacteric Scale.
Results
A total of 192 women were included. As the hot flush diaries from one study centre were lost, the assessment of hot flushes was based on 136 participants (soy: 54 women; placebo: 82 women). After 12 weeks, 180 women were available for the analysis of Greene Scale and safety (soy and placebo: each 90 women). Hot flushes were reduced by 43.3% (–3.5 hot flushes) with soy and by 30.8% with placebo (–2.6;
p
< 0.001). After the open treatment phase with soy, both original groups showed a reduction of 68% of hot flushes. A subgroup analysis showed better effects for soy when symptoms were classified as “severe” at baseline. After 12 weeks of double-blind treatment, there was an improvement from baseline values of 71 and 78% with soy with the items “hot flushes” and “sweating”, compared with 24% for both items with placebo. Hormonal safety parameters remained uninfluenced.
Conclusions
Soy germ extract with 100 mg of isoflavone glycosides was shown to modestly, but significantly reduce menopausal hot flushes.</description><identifier>ISSN: 0954-3007</identifier><identifier>EISSN: 1476-5640</identifier><identifier>DOI: 10.1038/s41430-018-0173-3</identifier><identifier>PMID: 29849181</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>692/699/2743 ; 692/700/2814 ; Aged ; Clinical Nutrition ; Diaries ; Double-Blind Method ; Double-blind studies ; Epidemiology ; Female ; Glycine max - chemistry ; Glycosides ; Glycosides - pharmacology ; Glycosides - therapeutic use ; Hot Flashes - drug therapy ; Humans ; Internal Medicine ; Isoflavones ; Isoflavones - pharmacology ; Isoflavones - therapeutic use ; Medicine ; Medicine & Public Health ; Menopause ; Metabolic Diseases ; Middle Aged ; Parameters ; Phytotherapy ; Plant Extracts - pharmacology ; Plant Extracts - therapeutic use ; Postmenopause ; Public Health ; Safety ; Seeds ; Soy products ; Subgroups ; Sweating ; Treatment Outcome</subject><ispartof>European journal of clinical nutrition, 2018-07, Vol.72 (7), p.961-970</ispartof><rights>The Author(s) 2018</rights><rights>2018. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c470t-bf57a20f39c2b41365ff87566de0482460704bbe75f35094b670024a640fcd2f3</citedby><cites>FETCH-LOGICAL-c470t-bf57a20f39c2b41365ff87566de0482460704bbe75f35094b670024a640fcd2f3</cites><orcidid>0000-0002-4488-4026</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/s41430-018-0173-3$$EPDF$$P50$$Gspringer$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/s41430-018-0173-3$$EHTML$$P50$$Gspringer$$Hfree_for_read</linktohtml><link.rule.ids>230,314,780,784,885,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29849181$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Imhof, Martin</creatorcontrib><creatorcontrib>Gocan, Anca</creatorcontrib><creatorcontrib>Imhof, Marianne</creatorcontrib><creatorcontrib>Schmidt, Mathias</creatorcontrib><title>Soy germ extract alleviates menopausal hot flushes: placebo-controlled double-blind trial</title><title>European journal of clinical nutrition</title><addtitle>Eur J Clin Nutr</addtitle><addtitle>Eur J Clin Nutr</addtitle><description>Background/objectives
A double-blind, placebo-controlled study was performed to assess the potency of a soy germ preparation for the alleviation of menopausal hot flushes.
Subjects/methods
Caucasian women with at least seven hot flushes daily were treated with soy germ extract (100 mg isoflavone glycosides) daily or with placebo for 12 weeks, followed by 12 weeks of open treatment with soy. Outcome parameters were the number of hot flushes and the evaluation of the Greene Climacteric Scale.
Results
A total of 192 women were included. As the hot flush diaries from one study centre were lost, the assessment of hot flushes was based on 136 participants (soy: 54 women; placebo: 82 women). After 12 weeks, 180 women were available for the analysis of Greene Scale and safety (soy and placebo: each 90 women). Hot flushes were reduced by 43.3% (–3.5 hot flushes) with soy and by 30.8% with placebo (–2.6;
p
< 0.001). After the open treatment phase with soy, both original groups showed a reduction of 68% of hot flushes. A subgroup analysis showed better effects for soy when symptoms were classified as “severe” at baseline. After 12 weeks of double-blind treatment, there was an improvement from baseline values of 71 and 78% with soy with the items “hot flushes” and “sweating”, compared with 24% for both items with placebo. Hormonal safety parameters remained uninfluenced.
Conclusions
Soy germ extract with 100 mg of isoflavone glycosides was shown to modestly, but significantly reduce menopausal hot flushes.</description><subject>692/699/2743</subject><subject>692/700/2814</subject><subject>Aged</subject><subject>Clinical Nutrition</subject><subject>Diaries</subject><subject>Double-Blind Method</subject><subject>Double-blind studies</subject><subject>Epidemiology</subject><subject>Female</subject><subject>Glycine max - chemistry</subject><subject>Glycosides</subject><subject>Glycosides - pharmacology</subject><subject>Glycosides - therapeutic use</subject><subject>Hot Flashes - drug therapy</subject><subject>Humans</subject><subject>Internal Medicine</subject><subject>Isoflavones</subject><subject>Isoflavones - pharmacology</subject><subject>Isoflavones - therapeutic use</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Menopause</subject><subject>Metabolic Diseases</subject><subject>Middle Aged</subject><subject>Parameters</subject><subject>Phytotherapy</subject><subject>Plant Extracts - pharmacology</subject><subject>Plant Extracts - therapeutic use</subject><subject>Postmenopause</subject><subject>Public Health</subject><subject>Safety</subject><subject>Seeds</subject><subject>Soy products</subject><subject>Subgroups</subject><subject>Sweating</subject><subject>Treatment Outcome</subject><issn>0954-3007</issn><issn>1476-5640</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp1kU9rFTEUxYNY7Gv1A7iRgBs3sTf_Z1wIpWgVCi7UhauQZJK-KZnJM5kp9ts35dWqBRfhLs7vntzDQeglhbcUeHdSBRUcCNCuPc0Jf4I2VGhFpBLwFG2gl4JwAH2Ijmq9AmiiZs_QIes70dOObtCPr_kGX4Yy4fBrKdYv2KYUrke7hIqnMOedXatNeJsXHNNat6G-w7tkfXCZ-DwvJTd-wENeXQrEpXEe8FJGm56jg2hTDS_u5zH6_vHDt7NP5OLL-eez0wvihYaFuCi1ZRB575kTlCsZY6elUkMA0TGhQINwLmgZuYReOKUBmLAtYfQDi_wYvd_77lY3hcGHdpNNZlfGyZYbk-1o_lXmcWsu87VRwCUVfTN4c29Q8s811MVMY_UhJTuHvFbDQOieKyV0Q18_Qq_yWuYWr1FK8k5oyhpF95QvudYS4sMxFMxdcWZfnGnFmbviDG87r_5O8bDxu6kGsD1QmzS3xv58_X_XW2wSpBE</recordid><startdate>20180701</startdate><enddate>20180701</enddate><creator>Imhof, Martin</creator><creator>Gocan, Anca</creator><creator>Imhof, Marianne</creator><creator>Schmidt, Mathias</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7RV</scope><scope>7TK</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-4488-4026</orcidid></search><sort><creationdate>20180701</creationdate><title>Soy germ extract alleviates menopausal hot flushes: placebo-controlled double-blind trial</title><author>Imhof, Martin ; Gocan, Anca ; Imhof, Marianne ; Schmidt, Mathias</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c470t-bf57a20f39c2b41365ff87566de0482460704bbe75f35094b670024a640fcd2f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>692/699/2743</topic><topic>692/700/2814</topic><topic>Aged</topic><topic>Clinical Nutrition</topic><topic>Diaries</topic><topic>Double-Blind Method</topic><topic>Double-blind studies</topic><topic>Epidemiology</topic><topic>Female</topic><topic>Glycine max - chemistry</topic><topic>Glycosides</topic><topic>Glycosides - pharmacology</topic><topic>Glycosides - therapeutic use</topic><topic>Hot Flashes - drug therapy</topic><topic>Humans</topic><topic>Internal Medicine</topic><topic>Isoflavones</topic><topic>Isoflavones - pharmacology</topic><topic>Isoflavones - therapeutic use</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Menopause</topic><topic>Metabolic Diseases</topic><topic>Middle Aged</topic><topic>Parameters</topic><topic>Phytotherapy</topic><topic>Plant Extracts - pharmacology</topic><topic>Plant Extracts - therapeutic use</topic><topic>Postmenopause</topic><topic>Public Health</topic><topic>Safety</topic><topic>Seeds</topic><topic>Soy products</topic><topic>Subgroups</topic><topic>Sweating</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Imhof, Martin</creatorcontrib><creatorcontrib>Gocan, Anca</creatorcontrib><creatorcontrib>Imhof, Marianne</creatorcontrib><creatorcontrib>Schmidt, Mathias</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Neurosciences Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Agricultural Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>European journal of clinical nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Imhof, Martin</au><au>Gocan, Anca</au><au>Imhof, Marianne</au><au>Schmidt, Mathias</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Soy germ extract alleviates menopausal hot flushes: placebo-controlled double-blind trial</atitle><jtitle>European journal of clinical nutrition</jtitle><stitle>Eur J Clin Nutr</stitle><addtitle>Eur J Clin Nutr</addtitle><date>2018-07-01</date><risdate>2018</risdate><volume>72</volume><issue>7</issue><spage>961</spage><epage>970</epage><pages>961-970</pages><issn>0954-3007</issn><eissn>1476-5640</eissn><abstract>Background/objectives
A double-blind, placebo-controlled study was performed to assess the potency of a soy germ preparation for the alleviation of menopausal hot flushes.
Subjects/methods
Caucasian women with at least seven hot flushes daily were treated with soy germ extract (100 mg isoflavone glycosides) daily or with placebo for 12 weeks, followed by 12 weeks of open treatment with soy. Outcome parameters were the number of hot flushes and the evaluation of the Greene Climacteric Scale.
Results
A total of 192 women were included. As the hot flush diaries from one study centre were lost, the assessment of hot flushes was based on 136 participants (soy: 54 women; placebo: 82 women). After 12 weeks, 180 women were available for the analysis of Greene Scale and safety (soy and placebo: each 90 women). Hot flushes were reduced by 43.3% (–3.5 hot flushes) with soy and by 30.8% with placebo (–2.6;
p
< 0.001). After the open treatment phase with soy, both original groups showed a reduction of 68% of hot flushes. A subgroup analysis showed better effects for soy when symptoms were classified as “severe” at baseline. After 12 weeks of double-blind treatment, there was an improvement from baseline values of 71 and 78% with soy with the items “hot flushes” and “sweating”, compared with 24% for both items with placebo. Hormonal safety parameters remained uninfluenced.
Conclusions
Soy germ extract with 100 mg of isoflavone glycosides was shown to modestly, but significantly reduce menopausal hot flushes.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>29849181</pmid><doi>10.1038/s41430-018-0173-3</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0002-4488-4026</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | 692/699/2743 692/700/2814 Aged Clinical Nutrition Diaries Double-Blind Method Double-blind studies Epidemiology Female Glycine max - chemistry Glycosides Glycosides - pharmacology Glycosides - therapeutic use Hot Flashes - drug therapy Humans Internal Medicine Isoflavones Isoflavones - pharmacology Isoflavones - therapeutic use Medicine Medicine & Public Health Menopause Metabolic Diseases Middle Aged Parameters Phytotherapy Plant Extracts - pharmacology Plant Extracts - therapeutic use Postmenopause Public Health Safety Seeds Soy products Subgroups Sweating Treatment Outcome |
| title | Soy germ extract alleviates menopausal hot flushes: placebo-controlled double-blind trial |
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