Disruption of adenosine 2A receptor exacerbates NAFLD through increasing inflammatory responses and SREBP1c activity

Adenosine 2A receptor (A2AR) exerts protective roles in endotoxin‐ and/or ischemia‐induced tissue damage. However, the role for A2AR in nonalcoholic fatty liver disease (NAFLD) remains largely unknown. We sought to examine the effects of global and/or myeloid cell‐specific A2AR disruption on the asp...

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Veröffentlicht in:	Hepatology (Baltimore, Md.) Md.), 2018-07, Vol.68 (1), p.48-61
Hauptverfasser:	Cai, Yuli, Li, Honggui, Liu, Mengyang, Pei, Ya, Zheng, Juan, Zhou, Jing, Luo, Xianjun, Huang, Wenya, Ma, Linqiang, Yang, Qiuhua, Guo, Shaodong, Xiao, Xiaoqiu, Li, Qifu, Zeng, Tianshu, Meng, Fanyin, Francis, Heather, Glaser, Shannon, Chen, Lulu, Huo, Yuqing, Alpini, Gianfranco, Wu, Chaodong
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Animals Bone marrow Cells, Cultured Diet, High-Fat - adverse effects Disease Progression Fatty liver Female Hepatocytes Hepatocytes - metabolism Hepatology High fat diet Inflammation Inflammation - metabolism Ischemia Liver diseases Macrophages Macrophages - metabolism Male Mice, Inbred C57BL Myeloid Cells - metabolism Non-alcoholic Fatty Liver Disease - metabolism Palmitic acid Receptor, Adenosine A2A - metabolism Rodents Steatosis Sterol Regulatory Element Binding Protein 1 - metabolism Transcription
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