A Targeted LC‐MS Strategy for Low‐Abundant HLA Class‐I‐Presented Peptide Detection Identifies Novel Human Papillomavirus T‐Cell Epitopes

For rational design of therapeutic vaccines, detailed knowledge about target epitopes that are endogenously processed and truly presented on infected or transformed cells is essential. Many potential target epitopes (viral or mutation‐derived), are presented at low abundance. Therefore, direct detec...

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Veröffentlicht in:	Proteomics (Weinheim) 2018-06, Vol.18 (11), p.e1700390-n/a
Hauptverfasser:	Blatnik, Renata, Mohan, Nitya, Bonsack, Maria, Falkenby, Lasse G., Hoppe, Stephanie, Josef, Kathrin, Steinbach, Alina, Becker, Sara, Nadler, Wiebke M., Rucevic, Marijana, Larsen, Martin R., Salek, Mogjiborahman, Riemer, Angelika B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Abundance Antigens Chromatography, Liquid - methods Contaminants Enzyme-linked immunosorbent assay Epitopes Epitopes, T-Lymphocyte - immunology Epitopes, T-Lymphocyte - metabolism Female Histocompatibility antigen HLA Histocompatibility Antigens Class I - immunology Histocompatibility Antigens Class I - metabolism Human papillomavirus human papillomavirus (HPV) Humans Immunogenicity immunopeptidomics Immunoprecipitation Immunotherapy Leukocytes Lymphocytes T neoepitopes Papillomaviridae - immunology Papillomavirus Infections - immunology Papillomavirus Infections - metabolism Papillomavirus Infections - virology Peptide Fragments - analysis Peptides Predictions Purification Tandem Mass Spectrometry - methods targeted mass spectrometry (MS) Transformed cells Tumor Cells, Cultured Uterine Cervical Neoplasms - immunology Uterine Cervical Neoplasms - metabolism Uterine Cervical Neoplasms - virology Vaccines
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