Cenicriviroc, a cytokine receptor antagonist, potentiates all‐trans retinoic acid in reducing liver injury in cholestatic rodents

Background & Aims Cholestatic liver injury is mediated by bile acid‐induced inflammatory responses. We hypothesized that superior therapeutic effects might be achieved by combining treatments that reduce the bile acid pool size with one that blocks inflammation. Methods Bile duct‐ligated (BDL) r...

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Veröffentlicht in:	Liver international 2018-06, Vol.38 (6), p.1128-1138
Hauptverfasser:	Yu, Dongke, Cai, Shi‐Ying, Mennone, Albert, Vig, Pamela, Boyer, James L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acids Animals ATP Binding Cassette Transporter, Subfamily B - genetics ATP-Binding Cassette Sub-Family B Member 4 Bile bile acid Bile Acids and Salts - metabolism Bile ducts Bilirubin Body weight CC chemokine receptors CCR2 protein CCR5 protein Cell proliferation cholestasis Cholestasis - complications Cholestasis - drug therapy Cholestasis - pathology combination therapy Cytokines Disease Models, Animal Drug Therapy, Combination Fibrosis Gangrene Hydroxyproline Imidazoles - pharmacology Infiltration Inflammation Injury prevention Leukocytes (neutrophilic) Ligation Liver Liver - pathology Liver diseases Liver Diseases - drug therapy Liver Diseases - etiology Liver Diseases - pathology Lymphocytes Lymphocytes T Macrophages Male Mice Mice, Knockout Monocyte chemoattractant protein 1 Necrosis Neutrophils Rats Rats, Sprague-Dawley Receptors, Cytokine - antagonists & inhibitors Retinoic acid Rodents Sulfoxides Synergistic effect Therapy Tretinoin - pharmacology Weight reduction
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