Quercetin Lowers Plasma Triglycerides Accompanied by White Adipose Tissue Browning in Diet-Induced Obese Mice

Obesity and dyslipidemia are major risk factors for the development of cardiovascular diseases (CVD). Quercetin, a natural flavonoid, lowers plasma triglycerides (TG) in human intervention studies, and its intake is associated with lower CVD risk. The aim of this study was to elucidate the mechanism...

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Veröffentlicht in:	International journal of molecular sciences 2018-06, Vol.19 (6), p.1786
Hauptverfasser:	Kuipers, Eline N, Dam, Andrea D van, Held, Ntsiki M, Mol, Isabel M, Houtkooper, Riekelt H, Rensen, Patrick C N, Boon, Mariëtte R
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipose tissue Adipose Tissue, Brown - drug effects Adipose Tissue, Brown - metabolism Adipose Tissue, White - drug effects Adipose Tissue, White - metabolism Animals Antioxidants - pharmacology Antioxidants - therapeutic use Body composition Browning Calories Cardiovascular diseases Diet, High-Fat - adverse effects Dyslipidemia Energy expenditure Fatty Acids - metabolism Food composition Food intake Gene expression Glycerol High fat diet Intestinal Absorption Intestine Liver Low density lipoprotein Male Mice Mice, Inbred C57BL Obesity Obesity - drug therapy Obesity - etiology Obesity - metabolism Proteins Quercetin Quercetin - pharmacology Quercetin - therapeutic use Risk analysis Risk factors Rodents Triglycerides Triglycerides - blood Uncoupling Protein 1 - genetics Uncoupling Protein 1 - metabolism
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