Dyspepsia amongst end stage renal disease undergoing hemodialysis: Views from a large tertiary care center
Gastrointestinal symptoms are common in patients with end stage renal disease (ESRD) among which dyspepsia is frequently observed. The aim of the study was to determine the frequency and associations of dyspepsia in ESRD patients using the Leeds questionnaire. All ESRD patients on maintenance hemodi...
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| Veröffentlicht in: | Journal of translational internal medicine 2018-06, Vol.6 (2), p.78-81 |
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| creator | Khalid, Muhammad Ali Iqbal, Jawaid Memon, Hassan Liaquat Hanif, Farina M. Butt, Muhammad Osama Tariq Luck, Nasir Hassan Majid, Zain |
| description | Gastrointestinal symptoms are common in patients with end stage renal disease (ESRD) among which dyspepsia is frequently observed. The aim of the study was to determine the frequency and associations of dyspepsia in ESRD patients using the Leeds questionnaire.
All ESRD patients on maintenance hemodialysis were consecutively enrolled in the study. Leeds questionnaire was used to interrogate the patients for the assessment of dyspepsia. Mean and standard deviation were calculated for age, body mass index (BMI), disease duration and number of hemodialysis sessions. Independent t-test and Chi square tests were used for statistical analysis.
Total number of patients was 200, out which 118 (59.3%) were male. The mean age was of 41.4 years. According to the Leeds questionnaire, dyspepsia was present in 62 (63.9%) patients. Younger patients (age 20-40 years) more frequently had dyspeptic symptoms (61.5% patients), retrosternal pain (156 patients, 78.0%), regurgitation (127 patients, 63.5%), dysphagia (67 patients, 33.5%), and nausea (142 patients, 71.0%). Patients presented with intermittent pattern of symptoms in 179 (89.5%) cases, while continuous symptoms in 6 (3.0%). Dyspepsia was associated with aspartate aminotransferase (AST) levels > 25 U/L (
= 0.001), alanine aminotransferase (ALT) levels > 28U/L (
= 0.000) and gamma glutamyl transferase (GGT) levels > 34 U/L (
= 0.002). On multivariate analysis, urea, creatinine, and presenting symptoms of dysphagia and belching showed significant statistical association with dyspepsia.
Dyspepsia is a common problem affecting patients with end stage renal disease and is associated with raised serum AST, ALT and GGT in such patients. |
| doi_str_mv | 10.2478/jtim-2018-0013 |
| format | Article |
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All ESRD patients on maintenance hemodialysis were consecutively enrolled in the study. Leeds questionnaire was used to interrogate the patients for the assessment of dyspepsia. Mean and standard deviation were calculated for age, body mass index (BMI), disease duration and number of hemodialysis sessions. Independent t-test and Chi square tests were used for statistical analysis.
Total number of patients was 200, out which 118 (59.3%) were male. The mean age was of 41.4 years. According to the Leeds questionnaire, dyspepsia was present in 62 (63.9%) patients. Younger patients (age 20-40 years) more frequently had dyspeptic symptoms (61.5% patients), retrosternal pain (156 patients, 78.0%), regurgitation (127 patients, 63.5%), dysphagia (67 patients, 33.5%), and nausea (142 patients, 71.0%). Patients presented with intermittent pattern of symptoms in 179 (89.5%) cases, while continuous symptoms in 6 (3.0%). Dyspepsia was associated with aspartate aminotransferase (AST) levels > 25 U/L (
= 0.001), alanine aminotransferase (ALT) levels > 28U/L (
= 0.000) and gamma glutamyl transferase (GGT) levels > 34 U/L (
= 0.002). On multivariate analysis, urea, creatinine, and presenting symptoms of dysphagia and belching showed significant statistical association with dyspepsia.
Dyspepsia is a common problem affecting patients with end stage renal disease and is associated with raised serum AST, ALT and GGT in such patients.</description><identifier>ISSN: 2450-131X</identifier><identifier>ISSN: 2224-4018</identifier><identifier>EISSN: 2224-4018</identifier><identifier>DOI: 10.2478/jtim-2018-0013</identifier><identifier>PMID: 29984202</identifier><language>eng</language><publisher>Poland: Sciendo</publisher><subject>Abdomen ; Age ; Ammonia ; Anorexia ; Body mass index ; Chi-square test ; Constipation ; Creatinine ; dyspepsia ; Dysphagia ; end stage renal disease (ESRD) ; Gastroesophageal reflux ; Gender ; Hemodialysis ; Inflammation ; Kidney diseases ; Leeds questionnaire ; Malnutrition ; Multivariate analysis ; Nausea ; Original ; Pain ; Patients ; Quality of life ; Questionnaires ; tertiary care center ; Vomiting</subject><ispartof>Journal of translational internal medicine, 2018-06, Vol.6 (2), p.78-81</ispartof><rights>2018. This work is published under http://creativecommons.org/licenses/by-nc-nd/3.0 (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2018 Muhammad Ali Khalid, Jawaid Iqbal, Hassan Liaquat Memon, Farina M. Hanif, Muhammad Osama Tariq Butt, Nasir Hassan Luck, Zain Majid, published by Sciendo 2018 Muhammad Ali Khalid, Jawaid Iqbal, Hassan Liaquat Memon, Farina M. Hanif, Muhammad Osama Tariq Butt, Nasir Hassan Luck, Zain Majid, published by Sciendo</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c469t-474717d836c094341db2764530ca2cdd5044d81496fc715b457c19278324de213</citedby><cites>FETCH-LOGICAL-c469t-474717d836c094341db2764530ca2cdd5044d81496fc715b457c19278324de213</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6032184/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6032184/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768,75907,75908</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29984202$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Khalid, Muhammad Ali</creatorcontrib><creatorcontrib>Iqbal, Jawaid</creatorcontrib><creatorcontrib>Memon, Hassan Liaquat</creatorcontrib><creatorcontrib>Hanif, Farina M.</creatorcontrib><creatorcontrib>Butt, Muhammad Osama Tariq</creatorcontrib><creatorcontrib>Luck, Nasir Hassan</creatorcontrib><creatorcontrib>Majid, Zain</creatorcontrib><title>Dyspepsia amongst end stage renal disease undergoing hemodialysis: Views from a large tertiary care center</title><title>Journal of translational internal medicine</title><addtitle>J Transl Int Med</addtitle><description>Gastrointestinal symptoms are common in patients with end stage renal disease (ESRD) among which dyspepsia is frequently observed. The aim of the study was to determine the frequency and associations of dyspepsia in ESRD patients using the Leeds questionnaire.
All ESRD patients on maintenance hemodialysis were consecutively enrolled in the study. Leeds questionnaire was used to interrogate the patients for the assessment of dyspepsia. Mean and standard deviation were calculated for age, body mass index (BMI), disease duration and number of hemodialysis sessions. Independent t-test and Chi square tests were used for statistical analysis.
Total number of patients was 200, out which 118 (59.3%) were male. The mean age was of 41.4 years. According to the Leeds questionnaire, dyspepsia was present in 62 (63.9%) patients. Younger patients (age 20-40 years) more frequently had dyspeptic symptoms (61.5% patients), retrosternal pain (156 patients, 78.0%), regurgitation (127 patients, 63.5%), dysphagia (67 patients, 33.5%), and nausea (142 patients, 71.0%). Patients presented with intermittent pattern of symptoms in 179 (89.5%) cases, while continuous symptoms in 6 (3.0%). Dyspepsia was associated with aspartate aminotransferase (AST) levels > 25 U/L (
= 0.001), alanine aminotransferase (ALT) levels > 28U/L (
= 0.000) and gamma glutamyl transferase (GGT) levels > 34 U/L (
= 0.002). On multivariate analysis, urea, creatinine, and presenting symptoms of dysphagia and belching showed significant statistical association with dyspepsia.
Dyspepsia is a common problem affecting patients with end stage renal disease and is associated with raised serum AST, ALT and GGT in such patients.</description><subject>Abdomen</subject><subject>Age</subject><subject>Ammonia</subject><subject>Anorexia</subject><subject>Body mass index</subject><subject>Chi-square test</subject><subject>Constipation</subject><subject>Creatinine</subject><subject>dyspepsia</subject><subject>Dysphagia</subject><subject>end stage renal disease (ESRD)</subject><subject>Gastroesophageal reflux</subject><subject>Gender</subject><subject>Hemodialysis</subject><subject>Inflammation</subject><subject>Kidney diseases</subject><subject>Leeds questionnaire</subject><subject>Malnutrition</subject><subject>Multivariate analysis</subject><subject>Nausea</subject><subject>Original</subject><subject>Pain</subject><subject>Patients</subject><subject>Quality of life</subject><subject>Questionnaires</subject><subject>tertiary care center</subject><subject>Vomiting</subject><issn>2450-131X</issn><issn>2224-4018</issn><issn>2224-4018</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNptkU1P3DAQhi1UBAi4cqws9RzwxyROOFSq6AdISFwAcbO89mzwKom3dgLaf1-nC5RKnDyaeead8byEnHB2KkDVZ6vR94VgvC4Y43KHHAghoICc-JRjKFnBJX_YJ8cprVhGSgVQN3tkXzRNDYKJA7L6vklrXCdvqOnD0KaR4uBoGk2LNOJgOup8QpOQToPD2AY_tPQR--C86TbJp3N67_E50WUMPTW0MzF3jhhHb-KGWhORWhxy4ojsLk2X8PjlPSR3P3_cXlwW1ze_ri6-XRcWqmYsQIHiytWysqwBCdwthKqglMwaYZ0rGYCrOTTV0ipeLqBUljdC1VKAQ8HlIfm61V1Pix7dPDyaTq-j7_NGOhiv_68M_lG34UlXTApeQxb48iIQw-8J06hXYYr5FElLXlZNKeAvdbqlbAwpRVy-TeBMz_bo2R4926Nne3LD5_d7veGvZmTgfAs8my7fy2Ebp00O_o3_WLmaP_8HKomgEg</recordid><startdate>20180601</startdate><enddate>20180601</enddate><creator>Khalid, Muhammad Ali</creator><creator>Iqbal, Jawaid</creator><creator>Memon, Hassan Liaquat</creator><creator>Hanif, Farina M.</creator><creator>Butt, Muhammad Osama Tariq</creator><creator>Luck, Nasir Hassan</creator><creator>Majid, Zain</creator><general>Sciendo</general><general>De Gruyter Poland</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>5PM</scope></search><sort><creationdate>20180601</creationdate><title>Dyspepsia amongst end stage renal disease undergoing hemodialysis: Views from a large tertiary care center</title><author>Khalid, Muhammad Ali ; Iqbal, Jawaid ; Memon, Hassan Liaquat ; Hanif, Farina M. ; Butt, Muhammad Osama Tariq ; Luck, Nasir Hassan ; Majid, Zain</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c469t-474717d836c094341db2764530ca2cdd5044d81496fc715b457c19278324de213</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Abdomen</topic><topic>Age</topic><topic>Ammonia</topic><topic>Anorexia</topic><topic>Body mass index</topic><topic>Chi-square test</topic><topic>Constipation</topic><topic>Creatinine</topic><topic>dyspepsia</topic><topic>Dysphagia</topic><topic>end stage renal disease (ESRD)</topic><topic>Gastroesophageal reflux</topic><topic>Gender</topic><topic>Hemodialysis</topic><topic>Inflammation</topic><topic>Kidney diseases</topic><topic>Leeds questionnaire</topic><topic>Malnutrition</topic><topic>Multivariate analysis</topic><topic>Nausea</topic><topic>Original</topic><topic>Pain</topic><topic>Patients</topic><topic>Quality of life</topic><topic>Questionnaires</topic><topic>tertiary care center</topic><topic>Vomiting</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Khalid, Muhammad Ali</creatorcontrib><creatorcontrib>Iqbal, Jawaid</creatorcontrib><creatorcontrib>Memon, Hassan Liaquat</creatorcontrib><creatorcontrib>Hanif, Farina M.</creatorcontrib><creatorcontrib>Butt, Muhammad Osama Tariq</creatorcontrib><creatorcontrib>Luck, Nasir Hassan</creatorcontrib><creatorcontrib>Majid, Zain</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of translational internal medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Khalid, Muhammad Ali</au><au>Iqbal, Jawaid</au><au>Memon, Hassan Liaquat</au><au>Hanif, Farina M.</au><au>Butt, Muhammad Osama Tariq</au><au>Luck, Nasir Hassan</au><au>Majid, Zain</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Dyspepsia amongst end stage renal disease undergoing hemodialysis: Views from a large tertiary care center</atitle><jtitle>Journal of translational internal medicine</jtitle><addtitle>J Transl Int Med</addtitle><date>2018-06-01</date><risdate>2018</risdate><volume>6</volume><issue>2</issue><spage>78</spage><epage>81</epage><pages>78-81</pages><issn>2450-131X</issn><issn>2224-4018</issn><eissn>2224-4018</eissn><abstract>Gastrointestinal symptoms are common in patients with end stage renal disease (ESRD) among which dyspepsia is frequently observed. The aim of the study was to determine the frequency and associations of dyspepsia in ESRD patients using the Leeds questionnaire.
All ESRD patients on maintenance hemodialysis were consecutively enrolled in the study. Leeds questionnaire was used to interrogate the patients for the assessment of dyspepsia. Mean and standard deviation were calculated for age, body mass index (BMI), disease duration and number of hemodialysis sessions. Independent t-test and Chi square tests were used for statistical analysis.
Total number of patients was 200, out which 118 (59.3%) were male. The mean age was of 41.4 years. According to the Leeds questionnaire, dyspepsia was present in 62 (63.9%) patients. Younger patients (age 20-40 years) more frequently had dyspeptic symptoms (61.5% patients), retrosternal pain (156 patients, 78.0%), regurgitation (127 patients, 63.5%), dysphagia (67 patients, 33.5%), and nausea (142 patients, 71.0%). Patients presented with intermittent pattern of symptoms in 179 (89.5%) cases, while continuous symptoms in 6 (3.0%). Dyspepsia was associated with aspartate aminotransferase (AST) levels > 25 U/L (
= 0.001), alanine aminotransferase (ALT) levels > 28U/L (
= 0.000) and gamma glutamyl transferase (GGT) levels > 34 U/L (
= 0.002). On multivariate analysis, urea, creatinine, and presenting symptoms of dysphagia and belching showed significant statistical association with dyspepsia.
Dyspepsia is a common problem affecting patients with end stage renal disease and is associated with raised serum AST, ALT and GGT in such patients.</abstract><cop>Poland</cop><pub>Sciendo</pub><pmid>29984202</pmid><doi>10.2478/jtim-2018-0013</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| source | EZB-FREE-00999 freely available EZB journals; PubMed Central; Walter De Gruyter: Open Access Journals |
| subjects | Abdomen Age Ammonia Anorexia Body mass index Chi-square test Constipation Creatinine dyspepsia Dysphagia end stage renal disease (ESRD) Gastroesophageal reflux Gender Hemodialysis Inflammation Kidney diseases Leeds questionnaire Malnutrition Multivariate analysis Nausea Original Pain Patients Quality of life Questionnaires tertiary care center Vomiting |
| title | Dyspepsia amongst end stage renal disease undergoing hemodialysis: Views from a large tertiary care center |
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