Insulin-Like Growth Factor-1 Signaling in Lung Development and Inflammatory Lung Diseases

Insulin-like growth factor-1 (IGF-1) was firstly identified as a hormone that mediates the biological effects of growth hormone. Accumulating data have indicated the role of IGF-1 signaling pathway in lung development and diseases such as congenital disorders, cancers, inflammation, and fibrosis. IG...

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Veröffentlicht in:	BioMed research international 2018-01, Vol.2018 (2018), p.1-27
Hauptverfasser:	Ma, Lijun, Wang, Yuming, Guo, Qiongya, Li, Wenting, Wang, Zheng, Zhang, Xiaoju
Format:	Artikel
Sprache:	eng
Schlagworte:	Alveoli Animal experimentation Animal models Animal research Animals Apoptosis Basal cells Bioindicators Biological effects Biomarkers Cancer therapies Cell adhesion & migration Cell cycle Chemical compounds Congenital diseases Cystic fibrosis Development and progression Developmental disabilities Diagnostic systems Diseases Disorders Endocrinology Epithelial cells Fibroblasts Fibrosis Growth Hormone Growth hormones Humans Hyperplasia Inflammation Inflammatory diseases Insulin Insulin-like growth factor I Insulin-Like Growth Factor I - physiology Insulin-like growth factors Kinases Ligands Lung - growth & development Lung - pathology Lung cancer Lung diseases Lung Diseases - immunology Lung Neoplasms Medical research Medicine, Experimental Metabolism Pediatrics Peptides Pharmacology Phosphorylation Proteins Pulmonary arteries Respiratory tract Review Signal Transduction Signaling Somatotropin
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