Insulin-Like Growth Factor-1 Signaling in Lung Development and Inflammatory Lung Diseases
Insulin-like growth factor-1 (IGF-1) was firstly identified as a hormone that mediates the biological effects of growth hormone. Accumulating data have indicated the role of IGF-1 signaling pathway in lung development and diseases such as congenital disorders, cancers, inflammation, and fibrosis. IG...
Gespeichert in:
| Veröffentlicht in: | BioMed research international 2018-01, Vol.2018 (2018), p.1-27 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 27 |
|---|---|
| container_issue | 2018 |
| container_start_page | 1 |
| container_title | BioMed research international |
| container_volume | 2018 |
| creator | Ma, Lijun Wang, Yuming Guo, Qiongya Li, Wenting Wang, Zheng Zhang, Xiaoju |
| description | Insulin-like growth factor-1 (IGF-1) was firstly identified as a hormone that mediates the biological effects of growth hormone. Accumulating data have indicated the role of IGF-1 signaling pathway in lung development and diseases such as congenital disorders, cancers, inflammation, and fibrosis. IGF-1 signaling modulates the development and differentiation of many types of lung cells, including airway basal cells, club cells, alveolar epithelial cells, and fibroblasts. IGF-1 signaling deficiency results in alveolar hyperplasia in humans and disrupted lung architecture in animal models. The components of IGF-1 signaling pathways are potentiated as biomarkers as they are dysregulated locally or systemically in lung diseases, whereas data may be inconsistent or even paradoxical among different studies. The usage of IGF-1-based therapeutic agents urges for more researches in developmental disorders and inflammatory lung diseases, as the majority of current data are collected from limited number of animal experiments and are generally less exuberant than those in lung cancer. Elucidation of these questions by further bench-to-bedside researches may provide us with rational clinical diagnostic approaches and agents concerning IGF-1 signaling in lung diseases. |
| doi_str_mv | 10.1155/2018/6057589 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6029485</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A621799489</galeid><sourcerecordid>A621799489</sourcerecordid><originalsourceid>FETCH-LOGICAL-c565t-a65ef96775e9829de6858721fa897d94c07a25b8fbd5733b476af4b9294c3fa23</originalsourceid><addsrcrecordid>eNqNkc1v1DAQxSNERavSG2cUiQtSCfVH_HVBqgptV1qpB-DAyZok9q5LYi920qr_PY522Zae6stYej-_mfErincYfcaYsTOCsDzjiAkm1aviiFBcVxzX-PX-TulhcZLSLcpHYo4Uf1McUpTfKYmPil8Ln6be-WrpfpvyKob7cV1eQjuGWOHyu1t5yOqqdL5cTrl-NXemD5vB-LEE35ULb3sYBsj8w45wyUAy6W1xYKFP5mRXj4ufl99-XFxXy5urxcX5smoZZ2MFnBmruBDMKElUZ7hkUhBsQSrRqbpFAghrpG06JihtasHB1o0iWaIWCD0uvmx9N1MzmK7Nk0Xo9Sa6AeKDDuD0_4p3a70Kd5qj7CFZNvi4M4jhz2TSqAeXWtP34E2YkiZIYKY44TP64Rl6G6aYv2imOJFYCYEeqRX0RjtvQ-7bzqb6nBMsVG6rMvVpS7UxpBSN3Y-MkZ7D1XO4ehduxt8_XXMP_4syA6dbYO18B_fuhXYmM8bCI42JyGnQv_0TtBg</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2062819770</pqid></control><display><type>article</type><title>Insulin-Like Growth Factor-1 Signaling in Lung Development and Inflammatory Lung Diseases</title><source>MEDLINE</source><source>Wiley Online Library Open Access</source><source>PubMed Central</source><source>Alma/SFX Local Collection</source><source>PubMed Central Open Access</source><creator>Ma, Lijun ; Wang, Yuming ; Guo, Qiongya ; Li, Wenting ; Wang, Zheng ; Zhang, Xiaoju</creator><contributor>Siafakas, Nikolaos</contributor><creatorcontrib>Ma, Lijun ; Wang, Yuming ; Guo, Qiongya ; Li, Wenting ; Wang, Zheng ; Zhang, Xiaoju ; Siafakas, Nikolaos</creatorcontrib><description>Insulin-like growth factor-1 (IGF-1) was firstly identified as a hormone that mediates the biological effects of growth hormone. Accumulating data have indicated the role of IGF-1 signaling pathway in lung development and diseases such as congenital disorders, cancers, inflammation, and fibrosis. IGF-1 signaling modulates the development and differentiation of many types of lung cells, including airway basal cells, club cells, alveolar epithelial cells, and fibroblasts. IGF-1 signaling deficiency results in alveolar hyperplasia in humans and disrupted lung architecture in animal models. The components of IGF-1 signaling pathways are potentiated as biomarkers as they are dysregulated locally or systemically in lung diseases, whereas data may be inconsistent or even paradoxical among different studies. The usage of IGF-1-based therapeutic agents urges for more researches in developmental disorders and inflammatory lung diseases, as the majority of current data are collected from limited number of animal experiments and are generally less exuberant than those in lung cancer. Elucidation of these questions by further bench-to-bedside researches may provide us with rational clinical diagnostic approaches and agents concerning IGF-1 signaling in lung diseases.</description><identifier>ISSN: 2314-6133</identifier><identifier>EISSN: 2314-6141</identifier><identifier>DOI: 10.1155/2018/6057589</identifier><identifier>PMID: 30018981</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Publishing Corporation</publisher><subject>Alveoli ; Animal experimentation ; Animal models ; Animal research ; Animals ; Apoptosis ; Basal cells ; Bioindicators ; Biological effects ; Biomarkers ; Cancer therapies ; Cell adhesion & migration ; Cell cycle ; Chemical compounds ; Congenital diseases ; Cystic fibrosis ; Development and progression ; Developmental disabilities ; Diagnostic systems ; Diseases ; Disorders ; Endocrinology ; Epithelial cells ; Fibroblasts ; Fibrosis ; Growth Hormone ; Growth hormones ; Humans ; Hyperplasia ; Inflammation ; Inflammatory diseases ; Insulin ; Insulin-like growth factor I ; Insulin-Like Growth Factor I - physiology ; Insulin-like growth factors ; Kinases ; Ligands ; Lung - growth & development ; Lung - pathology ; Lung cancer ; Lung diseases ; Lung Diseases - immunology ; Lung Neoplasms ; Medical research ; Medicine, Experimental ; Metabolism ; Pediatrics ; Peptides ; Pharmacology ; Phosphorylation ; Proteins ; Pulmonary arteries ; Respiratory tract ; Review ; Signal Transduction ; Signaling ; Somatotropin</subject><ispartof>BioMed research international, 2018-01, Vol.2018 (2018), p.1-27</ispartof><rights>Copyright © 2018 Zheng Wang et al.</rights><rights>COPYRIGHT 2018 John Wiley & Sons, Inc.</rights><rights>Copyright © 2018 Zheng Wang et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. https://creativecommons.org/licenses/by/4.0</rights><rights>Copyright © 2018 Zheng Wang et al. 2018</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c565t-a65ef96775e9829de6858721fa897d94c07a25b8fbd5733b476af4b9294c3fa23</citedby><cites>FETCH-LOGICAL-c565t-a65ef96775e9829de6858721fa897d94c07a25b8fbd5733b476af4b9294c3fa23</cites><orcidid>0000-0002-5189-0993 ; 0000-0001-7734-4838 ; 0000-0002-2833-8746</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6029485/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6029485/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30018981$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Siafakas, Nikolaos</contributor><creatorcontrib>Ma, Lijun</creatorcontrib><creatorcontrib>Wang, Yuming</creatorcontrib><creatorcontrib>Guo, Qiongya</creatorcontrib><creatorcontrib>Li, Wenting</creatorcontrib><creatorcontrib>Wang, Zheng</creatorcontrib><creatorcontrib>Zhang, Xiaoju</creatorcontrib><title>Insulin-Like Growth Factor-1 Signaling in Lung Development and Inflammatory Lung Diseases</title><title>BioMed research international</title><addtitle>Biomed Res Int</addtitle><description>Insulin-like growth factor-1 (IGF-1) was firstly identified as a hormone that mediates the biological effects of growth hormone. Accumulating data have indicated the role of IGF-1 signaling pathway in lung development and diseases such as congenital disorders, cancers, inflammation, and fibrosis. IGF-1 signaling modulates the development and differentiation of many types of lung cells, including airway basal cells, club cells, alveolar epithelial cells, and fibroblasts. IGF-1 signaling deficiency results in alveolar hyperplasia in humans and disrupted lung architecture in animal models. The components of IGF-1 signaling pathways are potentiated as biomarkers as they are dysregulated locally or systemically in lung diseases, whereas data may be inconsistent or even paradoxical among different studies. The usage of IGF-1-based therapeutic agents urges for more researches in developmental disorders and inflammatory lung diseases, as the majority of current data are collected from limited number of animal experiments and are generally less exuberant than those in lung cancer. Elucidation of these questions by further bench-to-bedside researches may provide us with rational clinical diagnostic approaches and agents concerning IGF-1 signaling in lung diseases.</description><subject>Alveoli</subject><subject>Animal experimentation</subject><subject>Animal models</subject><subject>Animal research</subject><subject>Animals</subject><subject>Apoptosis</subject><subject>Basal cells</subject><subject>Bioindicators</subject><subject>Biological effects</subject><subject>Biomarkers</subject><subject>Cancer therapies</subject><subject>Cell adhesion & migration</subject><subject>Cell cycle</subject><subject>Chemical compounds</subject><subject>Congenital diseases</subject><subject>Cystic fibrosis</subject><subject>Development and progression</subject><subject>Developmental disabilities</subject><subject>Diagnostic systems</subject><subject>Diseases</subject><subject>Disorders</subject><subject>Endocrinology</subject><subject>Epithelial cells</subject><subject>Fibroblasts</subject><subject>Fibrosis</subject><subject>Growth Hormone</subject><subject>Growth hormones</subject><subject>Humans</subject><subject>Hyperplasia</subject><subject>Inflammation</subject><subject>Inflammatory diseases</subject><subject>Insulin</subject><subject>Insulin-like growth factor I</subject><subject>Insulin-Like Growth Factor I - physiology</subject><subject>Insulin-like growth factors</subject><subject>Kinases</subject><subject>Ligands</subject><subject>Lung - growth & development</subject><subject>Lung - pathology</subject><subject>Lung cancer</subject><subject>Lung diseases</subject><subject>Lung Diseases - immunology</subject><subject>Lung Neoplasms</subject><subject>Medical research</subject><subject>Medicine, Experimental</subject><subject>Metabolism</subject><subject>Pediatrics</subject><subject>Peptides</subject><subject>Pharmacology</subject><subject>Phosphorylation</subject><subject>Proteins</subject><subject>Pulmonary arteries</subject><subject>Respiratory tract</subject><subject>Review</subject><subject>Signal Transduction</subject><subject>Signaling</subject><subject>Somatotropin</subject><issn>2314-6133</issn><issn>2314-6141</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>RHX</sourceid><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqNkc1v1DAQxSNERavSG2cUiQtSCfVH_HVBqgptV1qpB-DAyZok9q5LYi920qr_PY522Zae6stYej-_mfErincYfcaYsTOCsDzjiAkm1aviiFBcVxzX-PX-TulhcZLSLcpHYo4Uf1McUpTfKYmPil8Ln6be-WrpfpvyKob7cV1eQjuGWOHyu1t5yOqqdL5cTrl-NXemD5vB-LEE35ULb3sYBsj8w45wyUAy6W1xYKFP5mRXj4ufl99-XFxXy5urxcX5smoZZ2MFnBmruBDMKElUZ7hkUhBsQSrRqbpFAghrpG06JihtasHB1o0iWaIWCD0uvmx9N1MzmK7Nk0Xo9Sa6AeKDDuD0_4p3a70Kd5qj7CFZNvi4M4jhz2TSqAeXWtP34E2YkiZIYKY44TP64Rl6G6aYv2imOJFYCYEeqRX0RjtvQ-7bzqb6nBMsVG6rMvVpS7UxpBSN3Y-MkZ7D1XO4ehduxt8_XXMP_4syA6dbYO18B_fuhXYmM8bCI42JyGnQv_0TtBg</recordid><startdate>20180101</startdate><enddate>20180101</enddate><creator>Ma, Lijun</creator><creator>Wang, Yuming</creator><creator>Guo, Qiongya</creator><creator>Li, Wenting</creator><creator>Wang, Zheng</creator><creator>Zhang, Xiaoju</creator><general>Hindawi Publishing Corporation</general><general>Hindawi</general><general>John Wiley & Sons, Inc</general><general>Hindawi Limited</general><scope>ADJCN</scope><scope>AHFXO</scope><scope>RHU</scope><scope>RHW</scope><scope>RHX</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7QO</scope><scope>7T7</scope><scope>7TK</scope><scope>7U7</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>CWDGH</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-5189-0993</orcidid><orcidid>https://orcid.org/0000-0001-7734-4838</orcidid><orcidid>https://orcid.org/0000-0002-2833-8746</orcidid></search><sort><creationdate>20180101</creationdate><title>Insulin-Like Growth Factor-1 Signaling in Lung Development and Inflammatory Lung Diseases</title><author>Ma, Lijun ; Wang, Yuming ; Guo, Qiongya ; Li, Wenting ; Wang, Zheng ; Zhang, Xiaoju</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c565t-a65ef96775e9829de6858721fa897d94c07a25b8fbd5733b476af4b9294c3fa23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Alveoli</topic><topic>Animal experimentation</topic><topic>Animal models</topic><topic>Animal research</topic><topic>Animals</topic><topic>Apoptosis</topic><topic>Basal cells</topic><topic>Bioindicators</topic><topic>Biological effects</topic><topic>Biomarkers</topic><topic>Cancer therapies</topic><topic>Cell adhesion & migration</topic><topic>Cell cycle</topic><topic>Chemical compounds</topic><topic>Congenital diseases</topic><topic>Cystic fibrosis</topic><topic>Development and progression</topic><topic>Developmental disabilities</topic><topic>Diagnostic systems</topic><topic>Diseases</topic><topic>Disorders</topic><topic>Endocrinology</topic><topic>Epithelial cells</topic><topic>Fibroblasts</topic><topic>Fibrosis</topic><topic>Growth Hormone</topic><topic>Growth hormones</topic><topic>Humans</topic><topic>Hyperplasia</topic><topic>Inflammation</topic><topic>Inflammatory diseases</topic><topic>Insulin</topic><topic>Insulin-like growth factor I</topic><topic>Insulin-Like Growth Factor I - physiology</topic><topic>Insulin-like growth factors</topic><topic>Kinases</topic><topic>Ligands</topic><topic>Lung - growth & development</topic><topic>Lung - pathology</topic><topic>Lung cancer</topic><topic>Lung diseases</topic><topic>Lung Diseases - immunology</topic><topic>Lung Neoplasms</topic><topic>Medical research</topic><topic>Medicine, Experimental</topic><topic>Metabolism</topic><topic>Pediatrics</topic><topic>Peptides</topic><topic>Pharmacology</topic><topic>Phosphorylation</topic><topic>Proteins</topic><topic>Pulmonary arteries</topic><topic>Respiratory tract</topic><topic>Review</topic><topic>Signal Transduction</topic><topic>Signaling</topic><topic>Somatotropin</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ma, Lijun</creatorcontrib><creatorcontrib>Wang, Yuming</creatorcontrib><creatorcontrib>Guo, Qiongya</creatorcontrib><creatorcontrib>Li, Wenting</creatorcontrib><creatorcontrib>Wang, Zheng</creatorcontrib><creatorcontrib>Zhang, Xiaoju</creatorcontrib><collection>الدوريات العلمية والإحصائية - e-Marefa Academic and Statistical Periodicals</collection><collection>معرفة - المحتوى العربي الأكاديمي المتكامل - e-Marefa Academic Complete</collection><collection>Hindawi Publishing Complete</collection><collection>Hindawi Publishing Subscription Journals</collection><collection>Hindawi Publishing Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection (ProQuest)</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>Middle East & Africa Database</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>BioMed research international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ma, Lijun</au><au>Wang, Yuming</au><au>Guo, Qiongya</au><au>Li, Wenting</au><au>Wang, Zheng</au><au>Zhang, Xiaoju</au><au>Siafakas, Nikolaos</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Insulin-Like Growth Factor-1 Signaling in Lung Development and Inflammatory Lung Diseases</atitle><jtitle>BioMed research international</jtitle><addtitle>Biomed Res Int</addtitle><date>2018-01-01</date><risdate>2018</risdate><volume>2018</volume><issue>2018</issue><spage>1</spage><epage>27</epage><pages>1-27</pages><issn>2314-6133</issn><eissn>2314-6141</eissn><abstract>Insulin-like growth factor-1 (IGF-1) was firstly identified as a hormone that mediates the biological effects of growth hormone. Accumulating data have indicated the role of IGF-1 signaling pathway in lung development and diseases such as congenital disorders, cancers, inflammation, and fibrosis. IGF-1 signaling modulates the development and differentiation of many types of lung cells, including airway basal cells, club cells, alveolar epithelial cells, and fibroblasts. IGF-1 signaling deficiency results in alveolar hyperplasia in humans and disrupted lung architecture in animal models. The components of IGF-1 signaling pathways are potentiated as biomarkers as they are dysregulated locally or systemically in lung diseases, whereas data may be inconsistent or even paradoxical among different studies. The usage of IGF-1-based therapeutic agents urges for more researches in developmental disorders and inflammatory lung diseases, as the majority of current data are collected from limited number of animal experiments and are generally less exuberant than those in lung cancer. Elucidation of these questions by further bench-to-bedside researches may provide us with rational clinical diagnostic approaches and agents concerning IGF-1 signaling in lung diseases.</abstract><cop>Cairo, Egypt</cop><pub>Hindawi Publishing Corporation</pub><pmid>30018981</pmid><doi>10.1155/2018/6057589</doi><tpages>27</tpages><orcidid>https://orcid.org/0000-0002-5189-0993</orcidid><orcidid>https://orcid.org/0000-0001-7734-4838</orcidid><orcidid>https://orcid.org/0000-0002-2833-8746</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2314-6133 |
| ispartof | BioMed research international, 2018-01, Vol.2018 (2018), p.1-27 |
| issn | 2314-6133 2314-6141 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6029485 |
| source | MEDLINE; Wiley Online Library Open Access; PubMed Central; Alma/SFX Local Collection; PubMed Central Open Access |
| subjects | Alveoli Animal experimentation Animal models Animal research Animals Apoptosis Basal cells Bioindicators Biological effects Biomarkers Cancer therapies Cell adhesion & migration Cell cycle Chemical compounds Congenital diseases Cystic fibrosis Development and progression Developmental disabilities Diagnostic systems Diseases Disorders Endocrinology Epithelial cells Fibroblasts Fibrosis Growth Hormone Growth hormones Humans Hyperplasia Inflammation Inflammatory diseases Insulin Insulin-like growth factor I Insulin-Like Growth Factor I - physiology Insulin-like growth factors Kinases Ligands Lung - growth & development Lung - pathology Lung cancer Lung diseases Lung Diseases - immunology Lung Neoplasms Medical research Medicine, Experimental Metabolism Pediatrics Peptides Pharmacology Phosphorylation Proteins Pulmonary arteries Respiratory tract Review Signal Transduction Signaling Somatotropin |
| title | Insulin-Like Growth Factor-1 Signaling in Lung Development and Inflammatory Lung Diseases |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-07T23%3A14%3A36IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Insulin-Like%20Growth%20Factor-1%20Signaling%20in%20Lung%20Development%20and%20Inflammatory%20Lung%20Diseases&rft.jtitle=BioMed%20research%20international&rft.au=Ma,%20Lijun&rft.date=2018-01-01&rft.volume=2018&rft.issue=2018&rft.spage=1&rft.epage=27&rft.pages=1-27&rft.issn=2314-6133&rft.eissn=2314-6141&rft_id=info:doi/10.1155/2018/6057589&rft_dat=%3Cgale_pubme%3EA621799489%3C/gale_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2062819770&rft_id=info:pmid/30018981&rft_galeid=A621799489&rfr_iscdi=true |