Mechanism of vaccinia viral protein B14–mediated inhibition of IκB kinase β activation

Activation of IκB kinase β (IKKβ) is a central event in the NF-κB–mediated canonical pro-inflammatory pathway. Numerous studies have reported that oligomerization-mediated trans autophosphorylation of IKKβ is indispensable for its phosphorylation, leading to its activation and IKKβ-mediated phosphor...

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Veröffentlicht in:	The Journal of biological chemistry 2018-06, Vol.293 (26), p.10344-10352
Hauptverfasser:	Tang, Qingyu, Chakraborty, Sayan, Xu, Guozhou
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals autophosphorylation B14 Enzyme Activation Humans I-kappa B Proteins - chemistry I-kappa B Proteins - metabolism IKKβ, protein kinase inhibition mechanism Models, Molecular molecular docking Protein Binding Protein Domains protein kinase Protein Structure and Folding Protein Structure, Quaternary trans autophosphorylation Vaccinia virus Viral Proteins - metabolism virus Xenopus
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