The tetrameric structure of sialic acid–synthesizing UDP-GlcNAc 2-epimerase from Acinetobacter baumannii: A comparative study with human GNE

Sialic acid presentation on the cell surface by some pathogenic strains of bacteria allows their escape from the host immune system. It is one of the major virulence factors. Bacterial biosynthesis of sialic acids starts with the conversion of UDP-GlcNAc to UDP and ManNAc by a hydrolyzing 2-epimeras...

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Veröffentlicht in:	The Journal of biological chemistry 2018-06, Vol.293 (26), p.10119-10127
Hauptverfasser:	Ko, Tzu-Ping, Lai, Shu-Jung, Hsieh, Tung-Ju, Yang, Chia-Shin, Chen, Yeh
Format:	Artikel
Sprache:	eng
Schlagworte:	Acinetobacter baumannii - enzymology Carbohydrate Epimerases - chemistry Carbohydrate Epimerases - metabolism catalysis Catalytic Domain catalytic mechanism Conserved Sequence Humans hydrolase hydrolytic enzyme inhibition mechanism inhibitor inhibitor design Ligands N-acetyl neuraminic acid N-Acetylneuraminic Acid - biosynthesis oligomer protein crystallization Protein Multimerization protein oligomer Protein Structure and Folding Protein Structure, Quaternary
Online-Zugang:	Volltext
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