Ten-eleven translocation 2 demethylates the MMP9 promoter, and its down-regulation in preeclampsia impairs trophoblast migration and invasion

Preeclampsia is the most common clinical disorder in pregnancy and might result from disordered uterine environments caused by epigenetic modifications, including deregulation of DNA methylation/demethylation. Recent research has indicated that 5-hydroxymethylcytosine (5hmC), a DNA base derived from...

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Veröffentlicht in:	The Journal of biological chemistry 2018-06, Vol.293 (26), p.10059-10070
Hauptverfasser:	Li, Xiaoliang, Wu, Chunlian, Shen, Ying, Wang, Ke, Tang, Li, Zhou, Mi, Yang, Ming, Pan, Tianying, Liu, Xinghui, Xu, Wenming
Format:	Artikel
Sprache:	eng
Schlagworte:	Catalytic Domain Cell Line Cell Movement - genetics Cell Proliferation - genetics CpG Islands - genetics DNA demethylation DNA Methylation DNA-Binding Proteins - chemistry DNA-Binding Proteins - metabolism Down-Regulation - genetics epigenetics Female Gene Regulation Humans Matrix Metalloproteinase 9 - genetics metalloprotease methylation MMP9 placenta Pre-Eclampsia - genetics Pre-Eclampsia - metabolism Pre-Eclampsia - pathology preeclampsia Pregnancy pregnancy complication Promoter Regions, Genetic - genetics Proto-Oncogene Proteins - chemistry Proto-Oncogene Proteins - metabolism TET2 trophoblast Trophoblasts - pathology
Online-Zugang:	Volltext
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