Xpo7 is a broad-spectrum exportin and a nuclear import receptor

Exportins bind cargo molecules in a RanGTP-dependent manner inside nuclei and transport them through nuclear pores to the cytoplasm. CRM1/Xpo1 is the best-characterized exportin because specific inhibitors such as leptomycin B allow straightforward cargo validations in vivo. The analysis of other ex...

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Veröffentlicht in:	The Journal of cell biology 2018-07, Vol.217 (7), p.2329-2340
Hauptverfasser:	Aksu, Metin, Pleiner, Tino, Karaca, Samir, Kappert, Christin, Dehne, Heinz-Jürgen, Seibel, Katharina, Urlaub, Henning, Bohnsack, Markus T, Görlich, Dirk
Format:	Artikel
Sprache:	eng
Schlagworte:	Active Transport, Cell Nucleus - genetics Active Transport, Cell Nucleus - immunology Animals Camelids, New World - immunology Cargo Cell Nucleus - chemistry Cell Nucleus - genetics Cellular biology Cytoplasm Exportin 1 Protein Exports HeLa Cells Humans Imports Inhibitors Karyopherins - antagonists & inhibitors Karyopherins - chemistry Karyopherins - genetics Karyopherins - immunology Leptomycin B Mammals Molecular chains Molecules Nanobodies Nuclear Pore - genetics Nuclear Pore - immunology Nuclear pores Nuclear transport Oocytes - metabolism ran GTP-Binding Protein - antagonists & inhibitors ran GTP-Binding Protein - chemistry ran GTP-Binding Protein - genetics ran GTP-Binding Protein - immunology Receptors, Cytoplasmic and Nuclear - chemistry Receptors, Cytoplasmic and Nuclear - genetics Single-Domain Antibodies - genetics Single-Domain Antibodies - immunology Single-Domain Antibodies - pharmacology Substrates Xenopus laevis - genetics
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