Trim33 mediates the proinflammatory function of Th17 cells
Transforming growth factor-β (TGF-β) regulates reciprocal regulatory T cell (T reg) and T helper 17 (Th17) differentiation, the underlying mechanism of which is still not understood. Here, we report that tripartite motif-containing 33 (Trim33), a modulator of TGF-β signaling that associates with Sma...
Gespeichert in:
| Veröffentlicht in: | The Journal of experimental medicine 2018-07, Vol.215 (7), p.1853-1868 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1868 |
|---|---|
| container_issue | 7 |
| container_start_page | 1853 |
| container_title | The Journal of experimental medicine |
| container_volume | 215 |
| creator | Tanaka, Shinya Jiang, Yu Martinez, Gustavo J Tanaka, Kentaro Yan, Xiaowei Kurosaki, Tomohiro Kaartinen, Vesa Feng, Xin-Hua Tian, Qiang Wang, Xiaohu Dong, Chen |
| description | Transforming growth factor-β (TGF-β) regulates reciprocal regulatory T cell (T reg) and T helper 17 (Th17) differentiation, the underlying mechanism of which is still not understood. Here, we report that tripartite motif-containing 33 (Trim33), a modulator of TGF-β signaling that associates with Smad2, regulates the proinflammatory function of Th17 cells. Trim33 deficiency in T cells ameliorated an autoimmune disease in vivo
Trim33 was required for induction in vitro of Th17, but not T reg cells. Moreover, Smad4 and Trim33 play contrasting roles in the regulation of IL-10 expression; loss of Trim33 enhanced IL-10 production. Furthermore, Trim33 was recruited to the
and
gene loci, dependent on Smad2, and mediated their chromatin remodeling during Th17 differentiation. Trim33 thus promotes the proinflammatory function of Th17 cells by inducing IL-17 and suppressing IL-10 expression. |
| doi_str_mv | 10.1084/jem.20170779 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6028517</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2058505626</sourcerecordid><originalsourceid>FETCH-LOGICAL-c478t-17263fde4b08a525f15801a97bc64aae059695a4ea4d828d9dbe77118bfcfcb43</originalsourceid><addsrcrecordid>eNpdkUtLxDAUhYMozji6cy0FNy7seJMmTepCEPEFA27GdUjTxOnQNmPSCv57M8wDdXUX9-NwDh9C5ximGAS9WZp2SgBz4Lw4QGPMKKQFy8QhGgMQkmIAPkInISwBMKUsP0YjUhQZYKBjdDv3dZtlSWuqWvUmJP3CJCvv6s42qm1V7_x3YodO97XrEmeT-QLzRJumCafoyKommLPtnaD3p8f5w0s6e3t-fbifpZpy0aeYkzyzlaElCMUIs5gJwKrgpc6pUgZYkRdMUaNoJYioiqo0nGMsSqutLmk2QXeb3NVQxpradL1XjVzF4sp_S6dq-ffT1Qv54b5kDkQwzGPA1TbAu8_BhF62dVhPUJ1xQ5AEmGDA8thzgi7_oUs3-C7Oi1ROBOaUkEhdbyjtXQje2H0ZDHItRUYpcicl4he_B-zhnYXsB3unhzE</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2062817422</pqid></control><display><type>article</type><title>Trim33 mediates the proinflammatory function of Th17 cells</title><source>EZB-FREE-00999 freely available EZB journals</source><creator>Tanaka, Shinya ; Jiang, Yu ; Martinez, Gustavo J ; Tanaka, Kentaro ; Yan, Xiaowei ; Kurosaki, Tomohiro ; Kaartinen, Vesa ; Feng, Xin-Hua ; Tian, Qiang ; Wang, Xiaohu ; Dong, Chen</creator><creatorcontrib>Tanaka, Shinya ; Jiang, Yu ; Martinez, Gustavo J ; Tanaka, Kentaro ; Yan, Xiaowei ; Kurosaki, Tomohiro ; Kaartinen, Vesa ; Feng, Xin-Hua ; Tian, Qiang ; Wang, Xiaohu ; Dong, Chen</creatorcontrib><description>Transforming growth factor-β (TGF-β) regulates reciprocal regulatory T cell (T reg) and T helper 17 (Th17) differentiation, the underlying mechanism of which is still not understood. Here, we report that tripartite motif-containing 33 (Trim33), a modulator of TGF-β signaling that associates with Smad2, regulates the proinflammatory function of Th17 cells. Trim33 deficiency in T cells ameliorated an autoimmune disease in vivo
Trim33 was required for induction in vitro of Th17, but not T reg cells. Moreover, Smad4 and Trim33 play contrasting roles in the regulation of IL-10 expression; loss of Trim33 enhanced IL-10 production. Furthermore, Trim33 was recruited to the
and
gene loci, dependent on Smad2, and mediated their chromatin remodeling during Th17 differentiation. Trim33 thus promotes the proinflammatory function of Th17 cells by inducing IL-17 and suppressing IL-10 expression.</description><identifier>ISSN: 0022-1007</identifier><identifier>EISSN: 1540-9538</identifier><identifier>DOI: 10.1084/jem.20170779</identifier><identifier>PMID: 29930104</identifier><language>eng</language><publisher>United States: Rockefeller University Press</publisher><subject>Chromatin remodeling ; Differentiation ; Helper cells ; Inflammation ; Interleukin 1 ; Interleukin 10 ; Interleukin 17 ; Lymphocytes ; Lymphocytes T ; Signaling ; Smad2 protein ; Smad4 protein ; Transforming growth factor ; Transforming growth factor-b</subject><ispartof>The Journal of experimental medicine, 2018-07, Vol.215 (7), p.1853-1868</ispartof><rights>2018 Tanaka et al.</rights><rights>Copyright Rockefeller University Press Jul 2, 2018</rights><rights>2018 Tanaka et al. 2018</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c478t-17263fde4b08a525f15801a97bc64aae059695a4ea4d828d9dbe77118bfcfcb43</citedby><cites>FETCH-LOGICAL-c478t-17263fde4b08a525f15801a97bc64aae059695a4ea4d828d9dbe77118bfcfcb43</cites><orcidid>0000-0003-2104-964X ; 0000-0002-6352-304X ; 0000-0003-0178-3329 ; 0000-0002-0084-9130</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29930104$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tanaka, Shinya</creatorcontrib><creatorcontrib>Jiang, Yu</creatorcontrib><creatorcontrib>Martinez, Gustavo J</creatorcontrib><creatorcontrib>Tanaka, Kentaro</creatorcontrib><creatorcontrib>Yan, Xiaowei</creatorcontrib><creatorcontrib>Kurosaki, Tomohiro</creatorcontrib><creatorcontrib>Kaartinen, Vesa</creatorcontrib><creatorcontrib>Feng, Xin-Hua</creatorcontrib><creatorcontrib>Tian, Qiang</creatorcontrib><creatorcontrib>Wang, Xiaohu</creatorcontrib><creatorcontrib>Dong, Chen</creatorcontrib><title>Trim33 mediates the proinflammatory function of Th17 cells</title><title>The Journal of experimental medicine</title><addtitle>J Exp Med</addtitle><description>Transforming growth factor-β (TGF-β) regulates reciprocal regulatory T cell (T reg) and T helper 17 (Th17) differentiation, the underlying mechanism of which is still not understood. Here, we report that tripartite motif-containing 33 (Trim33), a modulator of TGF-β signaling that associates with Smad2, regulates the proinflammatory function of Th17 cells. Trim33 deficiency in T cells ameliorated an autoimmune disease in vivo
Trim33 was required for induction in vitro of Th17, but not T reg cells. Moreover, Smad4 and Trim33 play contrasting roles in the regulation of IL-10 expression; loss of Trim33 enhanced IL-10 production. Furthermore, Trim33 was recruited to the
and
gene loci, dependent on Smad2, and mediated their chromatin remodeling during Th17 differentiation. Trim33 thus promotes the proinflammatory function of Th17 cells by inducing IL-17 and suppressing IL-10 expression.</description><subject>Chromatin remodeling</subject><subject>Differentiation</subject><subject>Helper cells</subject><subject>Inflammation</subject><subject>Interleukin 1</subject><subject>Interleukin 10</subject><subject>Interleukin 17</subject><subject>Lymphocytes</subject><subject>Lymphocytes T</subject><subject>Signaling</subject><subject>Smad2 protein</subject><subject>Smad4 protein</subject><subject>Transforming growth factor</subject><subject>Transforming growth factor-b</subject><issn>0022-1007</issn><issn>1540-9538</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNpdkUtLxDAUhYMozji6cy0FNy7seJMmTepCEPEFA27GdUjTxOnQNmPSCv57M8wDdXUX9-NwDh9C5ximGAS9WZp2SgBz4Lw4QGPMKKQFy8QhGgMQkmIAPkInISwBMKUsP0YjUhQZYKBjdDv3dZtlSWuqWvUmJP3CJCvv6s42qm1V7_x3YodO97XrEmeT-QLzRJumCafoyKommLPtnaD3p8f5w0s6e3t-fbifpZpy0aeYkzyzlaElCMUIs5gJwKrgpc6pUgZYkRdMUaNoJYioiqo0nGMsSqutLmk2QXeb3NVQxpradL1XjVzF4sp_S6dq-ffT1Qv54b5kDkQwzGPA1TbAu8_BhF62dVhPUJ1xQ5AEmGDA8thzgi7_oUs3-C7Oi1ROBOaUkEhdbyjtXQje2H0ZDHItRUYpcicl4he_B-zhnYXsB3unhzE</recordid><startdate>20180702</startdate><enddate>20180702</enddate><creator>Tanaka, Shinya</creator><creator>Jiang, Yu</creator><creator>Martinez, Gustavo J</creator><creator>Tanaka, Kentaro</creator><creator>Yan, Xiaowei</creator><creator>Kurosaki, Tomohiro</creator><creator>Kaartinen, Vesa</creator><creator>Feng, Xin-Hua</creator><creator>Tian, Qiang</creator><creator>Wang, Xiaohu</creator><creator>Dong, Chen</creator><general>Rockefeller University Press</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7QP</scope><scope>7T5</scope><scope>7TK</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>M7N</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-2104-964X</orcidid><orcidid>https://orcid.org/0000-0002-6352-304X</orcidid><orcidid>https://orcid.org/0000-0003-0178-3329</orcidid><orcidid>https://orcid.org/0000-0002-0084-9130</orcidid></search><sort><creationdate>20180702</creationdate><title>Trim33 mediates the proinflammatory function of Th17 cells</title><author>Tanaka, Shinya ; Jiang, Yu ; Martinez, Gustavo J ; Tanaka, Kentaro ; Yan, Xiaowei ; Kurosaki, Tomohiro ; Kaartinen, Vesa ; Feng, Xin-Hua ; Tian, Qiang ; Wang, Xiaohu ; Dong, Chen</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c478t-17263fde4b08a525f15801a97bc64aae059695a4ea4d828d9dbe77118bfcfcb43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Chromatin remodeling</topic><topic>Differentiation</topic><topic>Helper cells</topic><topic>Inflammation</topic><topic>Interleukin 1</topic><topic>Interleukin 10</topic><topic>Interleukin 17</topic><topic>Lymphocytes</topic><topic>Lymphocytes T</topic><topic>Signaling</topic><topic>Smad2 protein</topic><topic>Smad4 protein</topic><topic>Transforming growth factor</topic><topic>Transforming growth factor-b</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tanaka, Shinya</creatorcontrib><creatorcontrib>Jiang, Yu</creatorcontrib><creatorcontrib>Martinez, Gustavo J</creatorcontrib><creatorcontrib>Tanaka, Kentaro</creatorcontrib><creatorcontrib>Yan, Xiaowei</creatorcontrib><creatorcontrib>Kurosaki, Tomohiro</creatorcontrib><creatorcontrib>Kaartinen, Vesa</creatorcontrib><creatorcontrib>Feng, Xin-Hua</creatorcontrib><creatorcontrib>Tian, Qiang</creatorcontrib><creatorcontrib>Wang, Xiaohu</creatorcontrib><creatorcontrib>Dong, Chen</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The Journal of experimental medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tanaka, Shinya</au><au>Jiang, Yu</au><au>Martinez, Gustavo J</au><au>Tanaka, Kentaro</au><au>Yan, Xiaowei</au><au>Kurosaki, Tomohiro</au><au>Kaartinen, Vesa</au><au>Feng, Xin-Hua</au><au>Tian, Qiang</au><au>Wang, Xiaohu</au><au>Dong, Chen</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Trim33 mediates the proinflammatory function of Th17 cells</atitle><jtitle>The Journal of experimental medicine</jtitle><addtitle>J Exp Med</addtitle><date>2018-07-02</date><risdate>2018</risdate><volume>215</volume><issue>7</issue><spage>1853</spage><epage>1868</epage><pages>1853-1868</pages><issn>0022-1007</issn><eissn>1540-9538</eissn><abstract>Transforming growth factor-β (TGF-β) regulates reciprocal regulatory T cell (T reg) and T helper 17 (Th17) differentiation, the underlying mechanism of which is still not understood. Here, we report that tripartite motif-containing 33 (Trim33), a modulator of TGF-β signaling that associates with Smad2, regulates the proinflammatory function of Th17 cells. Trim33 deficiency in T cells ameliorated an autoimmune disease in vivo
Trim33 was required for induction in vitro of Th17, but not T reg cells. Moreover, Smad4 and Trim33 play contrasting roles in the regulation of IL-10 expression; loss of Trim33 enhanced IL-10 production. Furthermore, Trim33 was recruited to the
and
gene loci, dependent on Smad2, and mediated their chromatin remodeling during Th17 differentiation. Trim33 thus promotes the proinflammatory function of Th17 cells by inducing IL-17 and suppressing IL-10 expression.</abstract><cop>United States</cop><pub>Rockefeller University Press</pub><pmid>29930104</pmid><doi>10.1084/jem.20170779</doi><tpages>16</tpages><orcidid>https://orcid.org/0000-0003-2104-964X</orcidid><orcidid>https://orcid.org/0000-0002-6352-304X</orcidid><orcidid>https://orcid.org/0000-0003-0178-3329</orcidid><orcidid>https://orcid.org/0000-0002-0084-9130</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0022-1007 |
| ispartof | The Journal of experimental medicine, 2018-07, Vol.215 (7), p.1853-1868 |
| issn | 0022-1007 1540-9538 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6028517 |
| source | EZB-FREE-00999 freely available EZB journals |
| subjects | Chromatin remodeling Differentiation Helper cells Inflammation Interleukin 1 Interleukin 10 Interleukin 17 Lymphocytes Lymphocytes T Signaling Smad2 protein Smad4 protein Transforming growth factor Transforming growth factor-b |
| title | Trim33 mediates the proinflammatory function of Th17 cells |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-10T08%3A13%3A24IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Trim33%20mediates%20the%20proinflammatory%20function%20of%20Th17%20cells&rft.jtitle=The%20Journal%20of%20experimental%20medicine&rft.au=Tanaka,%20Shinya&rft.date=2018-07-02&rft.volume=215&rft.issue=7&rft.spage=1853&rft.epage=1868&rft.pages=1853-1868&rft.issn=0022-1007&rft.eissn=1540-9538&rft_id=info:doi/10.1084/jem.20170779&rft_dat=%3Cproquest_pubme%3E2058505626%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2062817422&rft_id=info:pmid/29930104&rfr_iscdi=true |