Intracellular and extracellular loops of LRRC8 are essential for volume-regulated anion channel function

The volume-regulated anion channel (VRAC) is expressed ubiquitously in vertebrate cells and mediates swelling-induced release of Cl and organic solutes. Recent studies by several laboratories have demonstrated conclusively that VRAC is encoded by members of the leucine-rich repeat containing 8 ( ) g...

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Veröffentlicht in:	The Journal of general physiology 2018-07, Vol.150 (7), p.1003-1015
Hauptverfasser:	Yamada, Toshiki, Strange, Kevin
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino acid sequence Cell size Chimeras Extracellular matrix Intracellular Leucine Membranes Permeability Solutes Structure-function relationships Transmembrane domains Vertebrates
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