Destabilization of linker histone H1.2 is essential for ATM activation and DNA damage repair

Linker histone H1 is a master regulator of higher order chromatin structure, but its involvement in the DNA damage response and repair is unclear. Here, we report that linker histone H1.2 is an essential regulator of ataxia telangiectasia mutated (ATM) activation. We show that H1.2 protects chromati...

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Veröffentlicht in:	Cell research 2018-07, Vol.28 (7), p.756-770
Hauptverfasser:	Li, Zhiming, Li, Yinglu, Tang, Ming, Peng, Bin, Lu, Xiaopeng, Yang, Qiaoyan, Zhu, Qian, Hou, Tianyun, Li, Meiting, Liu, Chaohua, Wang, Lina, Xu, Xingzhi, Zhao, Ying, Wang, Haiying, Yang, Yang, Zhu, Wei-Guo
Format:	Artikel
Sprache:	eng
Schlagworte:	13/1 13/106 13/109 13/31 13/44 13/89 14/1 14/19 38/1 38/23 631/337/1427/2566 631/80/458/2389 82/58 Acid Anhydride Hydrolases Activation Adenosine diphosphate ADP-ribosylation Ataxia Ataxia telangiectasia mutated protein Ataxia Telangiectasia Mutated Proteins - metabolism Biomedical and Life Sciences Cell Biology Cell Cycle Proteins - metabolism Cell Survival Chromatin Chromatin - genetics Deoxyribonucleic acid Destabilization DNA DNA Damage DNA Repair DNA Repair Enzymes - metabolism DNA-Binding Proteins - metabolism HCT116 Cells HEK293 Cells HeLa Cells Histone H1 Histones - physiology Humans Life Sciences MRE11 Homologue Protein - metabolism MRE11 protein Mutation Nuclear Proteins - metabolism Poly (ADP-Ribose) Polymerase-1 - genetics Poly (ADP-Ribose) Polymerase-1 - metabolism Poly ADP Ribosylation Poly(ADP-ribose) polymerase Proteasomes Repair Ribosylation Structural damage
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