Outcomes of Adoptive Cell Transfer With Tumor-infiltrating Lymphocytes for Metastatic Melanoma Patients With and Without Brain Metastases

Brain metastases cause significant morbidity and mortality in patients with metastatic melanoma. Although adoptive cell therapy (ACT) with tumor-infiltrating lymphocytes (TIL) can achieve complete and durable remission of advanced cutaneous melanoma, the efficacy of this therapy for brain metastases...

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Veröffentlicht in:	Journal of immunotherapy (1997) 2018-06, Vol.41 (5), p.241-247
Hauptverfasser:	Mehta, Gautam U, Malekzadeh, Parisa, Shelton, Thomas, White, Donald E, Butman, John A, Yang, James C, Kammula, Udai S, Goff, Stephanie L, Rosenberg, Steven A, Sherry, Richard M
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Brain Neoplasms - immunology Brain Neoplasms - secondary Brain Neoplasms - therapy Female Follow-Up Studies Humans Immunotherapy, Adoptive - methods Lymphocytes, Tumor-Infiltrating - immunology Lymphocytes, Tumor-Infiltrating - transplantation Male Melanoma - immunology Melanoma - secondary Melanoma - therapy Melanoma, Cutaneous Malignant Middle Aged Neoplasm Metastasis Neoplasm Staging Retrospective Studies Skin Neoplasms - immunology Skin Neoplasms - pathology Skin Neoplasms - secondary Skin Neoplasms - therapy Treatment Outcome Young Adult
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