Live imaging of wound angiogenesis reveals macrophage orchestrated vessel sprouting and regression

Wound angiogenesis is an integral part of tissue repair and is impaired in many pathologies of healing. Here, we investigate the cellular interactions between innate immune cells and endothelial cells at wounds that drive neoangiogenic sprouting in real time and in vivo . Our studies in mouse and ze...

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Veröffentlicht in:	The EMBO journal 2018-07, Vol.37 (13), p.n/a
Hauptverfasser:	Gurevich, David B, Severn, Charlotte E, Twomey, Catherine, Greenhough, Alexander, Cash, Jenna, Toye, Ashley M, Mellor, Harry, Martin, Paul
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis Animals Animals, Genetically Modified Blood vessels Cell activation Cell culture Cells, Cultured Danio rerio Diagnostic Imaging EMBO11 EMBO46 Endothelial cells Fibroblasts Human Umbilical Vein Endothelial Cells Humans Immune clearance Immune system In vivo methods and tests Inflammation Leukocytes (neutrophilic) Macrophages Macrophages - physiology Male Mice, Inbred C57BL Neovascularization, Physiologic Neutrophils Phagocytes Regression Repair Tips Tissue culture Tumor necrosis factor Tumors Vascular endothelial growth factor wound Wound healing Wound Healing - physiology Zebrafish Zebrafish - genetics
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