The Bone Marrow Microenvironment in Health and Myeloid Malignancy
Hematopoietic stem cells (HSCs) interact dynamically with an intricate network of cells in the bone marrow (BM) microenvironment or niche. These interactions provide instructive cues that influence the production and lineage determination of different types of blood cells and maintenance of HSC quie...
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| Veröffentlicht in: | Cold Spring Harbor perspectives in medicine 2018-07, Vol.8 (7), p.a031328 |
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| container_title | Cold Spring Harbor perspectives in medicine |
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| creator | Galán-Díez, Marta Cuesta-Domínguez, Álvaro Kousteni, Stavroula |
| description | Hematopoietic stem cells (HSCs) interact dynamically with an intricate network of cells in the bone marrow (BM) microenvironment or niche. These interactions provide instructive cues that influence the production and lineage determination of different types of blood cells and maintenance of HSC quiescence. They also contribute to hematopoietic deregulation and hematological myeloid malignancies. Alterations in the BM niche are commonly observed in myeloid malignancies and contribute to the aberrant function of myelodysplastic and leukemia-initiating stem cells. In this work, we review how different components of the BM niche affect normal hematopoiesis, the molecular signals that govern this interaction, and how genetic changes in stromal cells or alterations in remodeled malignant BM niches contribute to myeloid malignancies. Understanding the intricacies between normal and malignant niches and their modulation may provide insights into developing novel therapeutics for blood disorders. |
| doi_str_mv | 10.1101/cshperspect.a031328 |
| format | Article |
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These interactions provide instructive cues that influence the production and lineage determination of different types of blood cells and maintenance of HSC quiescence. They also contribute to hematopoietic deregulation and hematological myeloid malignancies. Alterations in the BM niche are commonly observed in myeloid malignancies and contribute to the aberrant function of myelodysplastic and leukemia-initiating stem cells. In this work, we review how different components of the BM niche affect normal hematopoiesis, the molecular signals that govern this interaction, and how genetic changes in stromal cells or alterations in remodeled malignant BM niches contribute to myeloid malignancies. 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These interactions provide instructive cues that influence the production and lineage determination of different types of blood cells and maintenance of HSC quiescence. They also contribute to hematopoietic deregulation and hematological myeloid malignancies. Alterations in the BM niche are commonly observed in myeloid malignancies and contribute to the aberrant function of myelodysplastic and leukemia-initiating stem cells. In this work, we review how different components of the BM niche affect normal hematopoiesis, the molecular signals that govern this interaction, and how genetic changes in stromal cells or alterations in remodeled malignant BM niches contribute to myeloid malignancies. Understanding the intricacies between normal and malignant niches and their modulation may provide insights into developing novel therapeutics for blood disorders.</description><subject>Bone Marrow - physiology</subject><subject>Bone Marrow Neoplasms - pathology</subject><subject>Cellular Microenvironment - physiology</subject><subject>Chemokine CXCL12 - metabolism</subject><subject>Endothelial Cells - physiology</subject><subject>Hematopoiesis - physiology</subject><subject>Hematopoietic Stem Cells</subject><subject>Humans</subject><subject>Mesenchymal Stem Cells - metabolism</subject><subject>Nestin - metabolism</subject><subject>Neuroglia - physiology</subject><subject>Neurons - physiology</subject><subject>Osteoblasts - physiology</subject><subject>Osteocytes - physiology</subject><subject>Receptors, Leptin - metabolism</subject><subject>Stem Cell Niche - physiology</subject><subject>Sympathetic Nervous System - physiology</subject><issn>2157-1422</issn><issn>2472-5412</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkEFLAzEQhYMoVqq_QJA9etmaSbLZ3YtQRa1g8aLnkGYnbWSb1GRb6b93pbXoXGZg5r03fIRcAh0BULgxabHCmFZoupGmHDirjsgZEyXLCwHsuJ-hKHMQjA3IRUoftK9Cyqqkp2TAqlpygOKMjN8WmN0Fj9lUxxi-sqkzMaDfuBj8En2XOZ9NULfdItO-yaZbbIPru27d3GtvtufkxOo24cW-D8n748Pb_SR_eX16vh-_5EaU0OWGWsmorbDRVkprG2EYl1IINOVMzEAgr8oadIUcC15wirZilkGttZaNKfiQ3O58V-vZEhvT_xZ1q1bRLXXcqqCd-r_xbqHmYaMkZWXNaW9wvTeI4XONqVNLlwy2rfYY1klBLQoGPaGfLL477VmkFNEeYoCqH_7qD3-159-rrv5-eND80ubfFxGF2Q</recordid><startdate>20180701</startdate><enddate>20180701</enddate><creator>Galán-Díez, Marta</creator><creator>Cuesta-Domínguez, Álvaro</creator><creator>Kousteni, Stavroula</creator><general>Cold Spring Harbor Laboratory Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20180701</creationdate><title>The Bone Marrow Microenvironment in Health and Myeloid Malignancy</title><author>Galán-Díez, Marta ; Cuesta-Domínguez, Álvaro ; Kousteni, Stavroula</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c471t-c0f620f8edaf66ffd4c236644ec7b4b14e38791a8e3e53530ef82f219aaa6dc53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Bone Marrow - physiology</topic><topic>Bone Marrow Neoplasms - pathology</topic><topic>Cellular Microenvironment - physiology</topic><topic>Chemokine CXCL12 - metabolism</topic><topic>Endothelial Cells - physiology</topic><topic>Hematopoiesis - physiology</topic><topic>Hematopoietic Stem Cells</topic><topic>Humans</topic><topic>Mesenchymal Stem Cells - metabolism</topic><topic>Nestin - metabolism</topic><topic>Neuroglia - physiology</topic><topic>Neurons - physiology</topic><topic>Osteoblasts - physiology</topic><topic>Osteocytes - physiology</topic><topic>Receptors, Leptin - metabolism</topic><topic>Stem Cell Niche - physiology</topic><topic>Sympathetic Nervous System - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Galán-Díez, Marta</creatorcontrib><creatorcontrib>Cuesta-Domínguez, Álvaro</creatorcontrib><creatorcontrib>Kousteni, Stavroula</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Cold Spring Harbor perspectives in medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Galán-Díez, Marta</au><au>Cuesta-Domínguez, Álvaro</au><au>Kousteni, Stavroula</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Bone Marrow Microenvironment in Health and Myeloid Malignancy</atitle><jtitle>Cold Spring Harbor perspectives in medicine</jtitle><addtitle>Cold Spring Harb Perspect Med</addtitle><date>2018-07-01</date><risdate>2018</risdate><volume>8</volume><issue>7</issue><spage>a031328</spage><pages>a031328-</pages><issn>2157-1422</issn><eissn>2472-5412</eissn><abstract>Hematopoietic stem cells (HSCs) interact dynamically with an intricate network of cells in the bone marrow (BM) microenvironment or niche. 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| ispartof | Cold Spring Harbor perspectives in medicine, 2018-07, Vol.8 (7), p.a031328 |
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| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | Bone Marrow - physiology Bone Marrow Neoplasms - pathology Cellular Microenvironment - physiology Chemokine CXCL12 - metabolism Endothelial Cells - physiology Hematopoiesis - physiology Hematopoietic Stem Cells Humans Mesenchymal Stem Cells - metabolism Nestin - metabolism Neuroglia - physiology Neurons - physiology Osteoblasts - physiology Osteocytes - physiology Receptors, Leptin - metabolism Stem Cell Niche - physiology Sympathetic Nervous System - physiology |
| title | The Bone Marrow Microenvironment in Health and Myeloid Malignancy |
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