Optochemical Control of Biological Processes in Cells and Animals
Biological processes are naturally regulated with high spatial and temporal control, as is perhaps most evident in metazoan embryogenesis. Chemical tools have been extensively utilized in cell and developmental biology to investigate cellular processes, and conditional control methods have expanded...
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| Veröffentlicht in: | Angewandte Chemie International Edition 2018-03, Vol.57 (11), p.2768-2798 |
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| creator | Ankenbruck, Nicholas Courtney, Taylor Naro, Yuta Deiters, Alexander |
| description | Biological processes are naturally regulated with high spatial and temporal control, as is perhaps most evident in metazoan embryogenesis. Chemical tools have been extensively utilized in cell and developmental biology to investigate cellular processes, and conditional control methods have expanded applications of these technologies toward resolving complex biological questions. Light represents an excellent external trigger since it can be controlled with very high spatial and temporal precision. To this end, several optically regulated tools have been developed and applied to living systems. In this review we discuss recent developments of optochemical tools, including small molecules, peptides, proteins, and nucleic acids that can be irreversibly or reversibly controlled through light irradiation, with a focus on applications in cells and animals.
Light the way: Chemical tools have found broad applications in biology for investigating cellular processes. By combining these tools with light as an external trigger, high spatial and temporal precision can be achieved. This Review highlights recent developments in optochemical tools that can be irreversibly or reversibly controlled, with a focus on applications in cells and animals. |
| doi_str_mv | 10.1002/anie.201700171 |
| format | Article |
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Light the way: Chemical tools have found broad applications in biology for investigating cellular processes. By combining these tools with light as an external trigger, high spatial and temporal precision can be achieved. This Review highlights recent developments in optochemical tools that can be irreversibly or reversibly controlled, with a focus on applications in cells and animals.</description><edition>International ed. in English</edition><identifier>ISSN: 1433-7851</identifier><identifier>EISSN: 1521-3773</identifier><identifier>DOI: 10.1002/anie.201700171</identifier><identifier>PMID: 28521066</identifier><language>eng</language><publisher>Germany: Wiley Subscription Services, Inc</publisher><subject>Animals ; Biological activity ; caged compounds ; Cell Physiological Phenomena - drug effects ; Cell Physiological Phenomena - radiation effects ; chemical biology ; Control methods ; Developmental biology ; Drug Discovery - methods ; Embryogenesis ; Embryonic growth stage ; Humans ; Irradiation ; Light ; Light irradiation ; Molecular Docking Simulation ; Nucleic acids ; Nucleic Acids - genetics ; Nucleic Acids - metabolism ; optochemical tools ; Optogenetics - methods ; Peptides ; Peptides - genetics ; Peptides - metabolism ; Photochemical Processes ; photochemistry ; Photochemistry - methods ; photoswitches ; Protein Multimerization - drug effects ; Protein Multimerization - radiation effects ; Proteins ; Proteins - genetics ; Proteins - metabolism ; Small Molecule Libraries - chemistry ; Small Molecule Libraries - pharmacology</subject><ispartof>Angewandte Chemie International Edition, 2018-03, Vol.57 (11), p.2768-2798</ispartof><rights>2018 Wiley‐VCH Verlag GmbH & Co. KGaA, Weinheim</rights><rights>2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5711-2e754f5c9ef24bcd7a5b12a355a021abc63f0cbb59e97697313cbdef2ba31cd43</citedby><cites>FETCH-LOGICAL-c5711-2e754f5c9ef24bcd7a5b12a355a021abc63f0cbb59e97697313cbdef2ba31cd43</cites><orcidid>0000-0003-0234-9209</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fanie.201700171$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fanie.201700171$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,314,780,784,885,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28521066$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ankenbruck, Nicholas</creatorcontrib><creatorcontrib>Courtney, Taylor</creatorcontrib><creatorcontrib>Naro, Yuta</creatorcontrib><creatorcontrib>Deiters, Alexander</creatorcontrib><title>Optochemical Control of Biological Processes in Cells and Animals</title><title>Angewandte Chemie International Edition</title><addtitle>Angew Chem Int Ed Engl</addtitle><description>Biological processes are naturally regulated with high spatial and temporal control, as is perhaps most evident in metazoan embryogenesis. Chemical tools have been extensively utilized in cell and developmental biology to investigate cellular processes, and conditional control methods have expanded applications of these technologies toward resolving complex biological questions. Light represents an excellent external trigger since it can be controlled with very high spatial and temporal precision. To this end, several optically regulated tools have been developed and applied to living systems. In this review we discuss recent developments of optochemical tools, including small molecules, peptides, proteins, and nucleic acids that can be irreversibly or reversibly controlled through light irradiation, with a focus on applications in cells and animals.
Light the way: Chemical tools have found broad applications in biology for investigating cellular processes. By combining these tools with light as an external trigger, high spatial and temporal precision can be achieved. This Review highlights recent developments in optochemical tools that can be irreversibly or reversibly controlled, with a focus on applications in cells and animals.</description><subject>Animals</subject><subject>Biological activity</subject><subject>caged compounds</subject><subject>Cell Physiological Phenomena - drug effects</subject><subject>Cell Physiological Phenomena - radiation effects</subject><subject>chemical biology</subject><subject>Control methods</subject><subject>Developmental biology</subject><subject>Drug Discovery - methods</subject><subject>Embryogenesis</subject><subject>Embryonic growth stage</subject><subject>Humans</subject><subject>Irradiation</subject><subject>Light</subject><subject>Light irradiation</subject><subject>Molecular Docking Simulation</subject><subject>Nucleic acids</subject><subject>Nucleic Acids - genetics</subject><subject>Nucleic Acids - metabolism</subject><subject>optochemical tools</subject><subject>Optogenetics - methods</subject><subject>Peptides</subject><subject>Peptides - genetics</subject><subject>Peptides - metabolism</subject><subject>Photochemical Processes</subject><subject>photochemistry</subject><subject>Photochemistry - methods</subject><subject>photoswitches</subject><subject>Protein Multimerization - drug effects</subject><subject>Protein Multimerization - radiation effects</subject><subject>Proteins</subject><subject>Proteins - genetics</subject><subject>Proteins - metabolism</subject><subject>Small Molecule Libraries - chemistry</subject><subject>Small Molecule Libraries - pharmacology</subject><issn>1433-7851</issn><issn>1521-3773</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc9PwyAcxYnRuDm9ejRNvHjp5EeB9mJSm6lLFudBz4RSurG0ZZZVs_9e5ub8cfFAvgQ-PN7LA-AcwSGCEF_LxughhohDv9AB6COKUUg4J4d-HxES8piiHjhxbuH5OIbsGPRw7CnIWB-k0-XKqrmujZJVkNlm1doqsGVwa2xlZ5-nT61V2jntAtMEma4qF8imCNLG1LJyp-Co9EOf7eYAvNyNnrOHcDK9H2fpJFSUIxRizWlUUpXoEke5KrikOcKSUCohRjJXjJRQ5TlNdMJZwgkiKi88nEuCVBGRAbjZ6i67vNaF0t6qrMSy9S7atbDSiN83jZmLmX0TDGIWM-IFrnYCrX3ttFuJ2jjl48hG284JlEAYE_957NHLP-jCdm3j4wkMYYIoYXDjaLilVGuda3W5N4Og2LQjNu2IfTv-wcXPCHv8qw4PJFvg3VR6_Y-cSB_Ho2_xDyMGnAw</recordid><startdate>20180305</startdate><enddate>20180305</enddate><creator>Ankenbruck, Nicholas</creator><creator>Courtney, Taylor</creator><creator>Naro, Yuta</creator><creator>Deiters, Alexander</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TM</scope><scope>K9.</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-0234-9209</orcidid></search><sort><creationdate>20180305</creationdate><title>Optochemical Control of Biological Processes in Cells and Animals</title><author>Ankenbruck, Nicholas ; Courtney, Taylor ; Naro, Yuta ; Deiters, Alexander</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5711-2e754f5c9ef24bcd7a5b12a355a021abc63f0cbb59e97697313cbdef2ba31cd43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Animals</topic><topic>Biological activity</topic><topic>caged compounds</topic><topic>Cell Physiological Phenomena - drug effects</topic><topic>Cell Physiological Phenomena - radiation effects</topic><topic>chemical biology</topic><topic>Control methods</topic><topic>Developmental biology</topic><topic>Drug Discovery - methods</topic><topic>Embryogenesis</topic><topic>Embryonic growth stage</topic><topic>Humans</topic><topic>Irradiation</topic><topic>Light</topic><topic>Light irradiation</topic><topic>Molecular Docking Simulation</topic><topic>Nucleic acids</topic><topic>Nucleic Acids - genetics</topic><topic>Nucleic Acids - metabolism</topic><topic>optochemical tools</topic><topic>Optogenetics - methods</topic><topic>Peptides</topic><topic>Peptides - genetics</topic><topic>Peptides - metabolism</topic><topic>Photochemical Processes</topic><topic>photochemistry</topic><topic>Photochemistry - methods</topic><topic>photoswitches</topic><topic>Protein Multimerization - drug effects</topic><topic>Protein Multimerization - radiation effects</topic><topic>Proteins</topic><topic>Proteins - genetics</topic><topic>Proteins - metabolism</topic><topic>Small Molecule Libraries - chemistry</topic><topic>Small Molecule Libraries - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ankenbruck, Nicholas</creatorcontrib><creatorcontrib>Courtney, Taylor</creatorcontrib><creatorcontrib>Naro, Yuta</creatorcontrib><creatorcontrib>Deiters, Alexander</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Nucleic Acids Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Angewandte Chemie International Edition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ankenbruck, Nicholas</au><au>Courtney, Taylor</au><au>Naro, Yuta</au><au>Deiters, Alexander</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Optochemical Control of Biological Processes in Cells and Animals</atitle><jtitle>Angewandte Chemie International Edition</jtitle><addtitle>Angew Chem Int Ed Engl</addtitle><date>2018-03-05</date><risdate>2018</risdate><volume>57</volume><issue>11</issue><spage>2768</spage><epage>2798</epage><pages>2768-2798</pages><issn>1433-7851</issn><eissn>1521-3773</eissn><abstract>Biological processes are naturally regulated with high spatial and temporal control, as is perhaps most evident in metazoan embryogenesis. Chemical tools have been extensively utilized in cell and developmental biology to investigate cellular processes, and conditional control methods have expanded applications of these technologies toward resolving complex biological questions. Light represents an excellent external trigger since it can be controlled with very high spatial and temporal precision. To this end, several optically regulated tools have been developed and applied to living systems. In this review we discuss recent developments of optochemical tools, including small molecules, peptides, proteins, and nucleic acids that can be irreversibly or reversibly controlled through light irradiation, with a focus on applications in cells and animals.
Light the way: Chemical tools have found broad applications in biology for investigating cellular processes. By combining these tools with light as an external trigger, high spatial and temporal precision can be achieved. This Review highlights recent developments in optochemical tools that can be irreversibly or reversibly controlled, with a focus on applications in cells and animals.</abstract><cop>Germany</cop><pub>Wiley Subscription Services, Inc</pub><pmid>28521066</pmid><doi>10.1002/anie.201700171</doi><tpages>31</tpages><edition>International ed. in English</edition><orcidid>https://orcid.org/0000-0003-0234-9209</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Animals Biological activity caged compounds Cell Physiological Phenomena - drug effects Cell Physiological Phenomena - radiation effects chemical biology Control methods Developmental biology Drug Discovery - methods Embryogenesis Embryonic growth stage Humans Irradiation Light Light irradiation Molecular Docking Simulation Nucleic acids Nucleic Acids - genetics Nucleic Acids - metabolism optochemical tools Optogenetics - methods Peptides Peptides - genetics Peptides - metabolism Photochemical Processes photochemistry Photochemistry - methods photoswitches Protein Multimerization - drug effects Protein Multimerization - radiation effects Proteins Proteins - genetics Proteins - metabolism Small Molecule Libraries - chemistry Small Molecule Libraries - pharmacology |
| title | Optochemical Control of Biological Processes in Cells and Animals |
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