Regulation of Apolipoprotein E Trafficking by Hepatitis C Virus-Induced Autophagy

Apolipoprotein E (ApoE) plays an important role in the maturation and infectivity of hepatitis C virus (HCV). By analyzing the subcellular localization of ApoE in Huh7 hepatoma cells that harbored an HCV subgenomic RNA replicon, we found that ApoE colocalized with autophagosomes. This colocalization...

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Veröffentlicht in:	Journal of virology 2018-07, Vol.92 (14)
Hauptverfasser:	Kim, Ja Yeon, Ou, Jing-Hsiung James
Format:	Artikel
Sprache:	eng
Schlagworte:	Apolipoproteins E - metabolism Autophagosomes - metabolism Autophagy Autophagy-Related Protein 7 - genetics Autophagy-Related Protein 7 - metabolism Cell Line, Tumor Gene Knockdown Techniques Hepacivirus - genetics Hepacivirus - physiology Hepatitis C - metabolism Hepatitis C - virology Host-Pathogen Interactions Humans Spotlight Viral Envelope Proteins - metabolism Viral Load Virus Replication Virus-Cell Interactions
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