Co-protoporphyrin IX and Sn-protoporphyrin IX inactivate Zika, Chikungunya and other arboviruses by targeting the viral envelope
The global situation of diseases transmitted by arthropod-borne viruses such as Dengue (DENV), Yellow Fever (YFV), Chikungunya (CHIKV) and Zika (ZIKV) viruses is alarming and treatment of human infection by these arboviruses faces several challenges. The discovery of broad-spectrum antiviral molecul...
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| Veröffentlicht in: | Scientific reports 2018-06, Vol.8 (1), p.9805-13, Article 9805 |
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| creator | Neris, Romulo L. S. Figueiredo, Camila M. Higa, Luiza M. Araujo, Daniel F. Carvalho, Carlos A. M. Verçoza, Brunno R. F. Silva, Mariana O. L. Carneiro, Fabiana A. Tanuri, Amilcar Gomes, Andre M. O. Bozza, Marcelo T. Da Poian, Andrea T. Cruz-Oliveira, Christine Assunção-Miranda, Iranaia |
| description | The global situation of diseases transmitted by arthropod-borne viruses such as Dengue (DENV), Yellow Fever (YFV), Chikungunya (CHIKV) and Zika (ZIKV) viruses is alarming and treatment of human infection by these arboviruses faces several challenges. The discovery of broad-spectrum antiviral molecules, able to inactivate different groups of viruses, is an interesting approach. The viral envelope is a common structure among arboviruses, being a potential target for antivirals. Porphyrins are amphipathic molecules able to interact with membranes and absorb light, being widely used in photodynamic therapy. Previously, we showed that heme, Co-protoporphyrin IX (CoPPIX) and Sn-protoporphyrin IX (SnPPIX) directly inactivate DENV and YFV infectious particles. Here we demonstrate that the antiviral activity of these porphyrins can be broadened to CHIKV, ZIKV, Mayaro virus, Sindbis virus and Vesicular Stomatitis virus. Porphyrin treatment causes viral envelope protein loss, affecting viral morphology, adsorption and entry into target cells. Also, light-stimulation enhanced the SnPPIX activity against all tested arboviruses. In summary, CoPPIX and SnPPIX were shown to be efficient broad-spectrum compounds to inactivate medically and veterinary important viruses. |
| doi_str_mv | 10.1038/s41598-018-27855-7 |
| format | Article |
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S. ; Figueiredo, Camila M. ; Higa, Luiza M. ; Araujo, Daniel F. ; Carvalho, Carlos A. M. ; Verçoza, Brunno R. F. ; Silva, Mariana O. L. ; Carneiro, Fabiana A. ; Tanuri, Amilcar ; Gomes, Andre M. O. ; Bozza, Marcelo T. ; Da Poian, Andrea T. ; Cruz-Oliveira, Christine ; Assunção-Miranda, Iranaia</creator><creatorcontrib>Neris, Romulo L. S. ; Figueiredo, Camila M. ; Higa, Luiza M. ; Araujo, Daniel F. ; Carvalho, Carlos A. M. ; Verçoza, Brunno R. F. ; Silva, Mariana O. L. ; Carneiro, Fabiana A. ; Tanuri, Amilcar ; Gomes, Andre M. O. ; Bozza, Marcelo T. ; Da Poian, Andrea T. ; Cruz-Oliveira, Christine ; Assunção-Miranda, Iranaia</creatorcontrib><description>The global situation of diseases transmitted by arthropod-borne viruses such as Dengue (DENV), Yellow Fever (YFV), Chikungunya (CHIKV) and Zika (ZIKV) viruses is alarming and treatment of human infection by these arboviruses faces several challenges. The discovery of broad-spectrum antiviral molecules, able to inactivate different groups of viruses, is an interesting approach. The viral envelope is a common structure among arboviruses, being a potential target for antivirals. Porphyrins are amphipathic molecules able to interact with membranes and absorb light, being widely used in photodynamic therapy. Previously, we showed that heme, Co-protoporphyrin IX (CoPPIX) and Sn-protoporphyrin IX (SnPPIX) directly inactivate DENV and YFV infectious particles. Here we demonstrate that the antiviral activity of these porphyrins can be broadened to CHIKV, ZIKV, Mayaro virus, Sindbis virus and Vesicular Stomatitis virus. Porphyrin treatment causes viral envelope protein loss, affecting viral morphology, adsorption and entry into target cells. Also, light-stimulation enhanced the SnPPIX activity against all tested arboviruses. 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S.</au><au>Figueiredo, Camila M.</au><au>Higa, Luiza M.</au><au>Araujo, Daniel F.</au><au>Carvalho, Carlos A. M.</au><au>Verçoza, Brunno R. F.</au><au>Silva, Mariana O. L.</au><au>Carneiro, Fabiana A.</au><au>Tanuri, Amilcar</au><au>Gomes, Andre M. 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The discovery of broad-spectrum antiviral molecules, able to inactivate different groups of viruses, is an interesting approach. The viral envelope is a common structure among arboviruses, being a potential target for antivirals. Porphyrins are amphipathic molecules able to interact with membranes and absorb light, being widely used in photodynamic therapy. Previously, we showed that heme, Co-protoporphyrin IX (CoPPIX) and Sn-protoporphyrin IX (SnPPIX) directly inactivate DENV and YFV infectious particles. Here we demonstrate that the antiviral activity of these porphyrins can be broadened to CHIKV, ZIKV, Mayaro virus, Sindbis virus and Vesicular Stomatitis virus. Porphyrin treatment causes viral envelope protein loss, affecting viral morphology, adsorption and entry into target cells. Also, light-stimulation enhanced the SnPPIX activity against all tested arboviruses. 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| source | Nature Free; DOAJ Directory of Open Access Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central; Alma/SFX Local Collection; Free Full-Text Journals in Chemistry; Springer Nature OA Free Journals |
| subjects | 101/28 13 14 631/326/22/1295 631/326/596/1296 82/29 Antiviral activity Antiviral agents Chikungunya virus Dengue fever Disease transmission Heme Humanities and Social Sciences multidisciplinary Photodynamic therapy Porphyrins Protoporphyrin IX Science Science (multidisciplinary) Stomatitis Tin protoporphyrin Vector-borne diseases Viral envelope proteins Viruses Yellow fever Zika virus |
| title | Co-protoporphyrin IX and Sn-protoporphyrin IX inactivate Zika, Chikungunya and other arboviruses by targeting the viral envelope |
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