Activated Microglia Targeting Dendrimer–Minocycline Conjugate as Therapeutics for Neuroinflammation

Brain-related disorders have outmatched cancer and cardiovascular diseases worldwide as the leading cause of morbidity and mortality. The lack of effective therapies and the relatively dry central nervous system (CNS) drug pipeline pose formidable challenge. Superior, targeted delivery of current cl...

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Veröffentlicht in:	Bioconjugate chemistry 2017-11, Vol.28 (11), p.2874-2886
Hauptverfasser:	Sharma, Rishi, Kim, Soo-Young, Sharma, Anjali, Zhang, Zhi, Kambhampati, Siva Pramodh, Kannan, Sujatha, Kannan, Rangaramanujam M
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkynes Animal models Animals Anti-Inflammatory Agents - administration & dosage Anti-Inflammatory Agents - chemistry Anti-Inflammatory Agents - therapeutic use Antioxidants Blood circulation Blood-brain barrier Brain diseases Cancer Cardiovascular diseases Central nervous system Cerebral Palsy - complications Cerebral Palsy - drug therapy Cerebral Palsy - immunology Chemical reactions Corpus callosum Dendrimers Dendrimers - chemistry Disorders Drug Carriers - chemistry Drug delivery Drug Delivery Systems Drugs Heart diseases In vivo methods and tests Inflammation Inflammation - complications Inflammation - drug therapy Inflammation - immunology Intravenous administration Lipopolysaccharides Medical treatment Microglia Microglia - drug effects Microglia - immunology Microglial cells Minocycline Minocycline - administration & dosage Minocycline - chemistry Minocycline - therapeutic use Morbidity Neuroimaging Neurological diseases Neurological disorders Nitric oxide Oxidative stress Paralysis Rabbits Side effects Stability Substantia alba Tumor necrosis factor Ventricle Ventricles (cerebral)
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