Evaluation of the Protective Effect of Olive Leaf Extract on Cisplatin-Induced Testicular Damage in Rats
In the present investigation, the effect of olive leaf extract (OLE) on testicular damage induced in rats by an intraperitoneal injection of cisplatin (cis-diamminedichloroplatinum (CDDP)) at a dose of 5 mg/kg was tested. Rats were randomly divided into 4 groups: control, CDDP, OLE, and OLE + CDDP....
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| Veröffentlicht in: | Oxidative medicine and cellular longevity 2018-01, Vol.2018 (2018), p.1-11 |
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| description | In the present investigation, the effect of olive leaf extract (OLE) on testicular damage induced in rats by an intraperitoneal injection of cisplatin (cis-diamminedichloroplatinum (CDDP)) at a dose of 5 mg/kg was tested. Rats were randomly divided into 4 groups: control, CDDP, OLE, and OLE + CDDP. After 5 days of CDDP treatment, body and testicular weights, histopathological alteration, and serum male sex hormone levels were determined. In addition to the biochemical and immunohistochemical changes in the testes, CDDP caused the disorganization of germinal epithelium and apoptosis by inducing Bax and inhibiting Bcl-2 protein expression. Testicular weights, catalase, serum testosterone, testicular enzymatic (including glutathione peroxidase, glutathione reductase, and superoxide dismutase) along with nonenzymatic (glutathione) antioxidants, and levels of luteinizing and follicle-stimulating hormones were significantly reduced in addition to a significant increase in testicular malondialdehyde and nitrite/nitrate levels when compared with the control group. OLE treatment markedly attenuated both biochemical and histopathological changes. The reproductive beneficial effects of OLE were mediated, at least partly, by inducing the nuclear factor erythroid 2-related factor 2 (Nrf2)/heme oxygenase 1 (HO-1) pathway. |
| doi_str_mv | 10.1155/2018/8487248 |
| format | Article |
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Rats were randomly divided into 4 groups: control, CDDP, OLE, and OLE + CDDP. After 5 days of CDDP treatment, body and testicular weights, histopathological alteration, and serum male sex hormone levels were determined. In addition to the biochemical and immunohistochemical changes in the testes, CDDP caused the disorganization of germinal epithelium and apoptosis by inducing Bax and inhibiting Bcl-2 protein expression. Testicular weights, catalase, serum testosterone, testicular enzymatic (including glutathione peroxidase, glutathione reductase, and superoxide dismutase) along with nonenzymatic (glutathione) antioxidants, and levels of luteinizing and follicle-stimulating hormones were significantly reduced in addition to a significant increase in testicular malondialdehyde and nitrite/nitrate levels when compared with the control group. OLE treatment markedly attenuated both biochemical and histopathological changes. The reproductive beneficial effects of OLE were mediated, at least partly, by inducing the nuclear factor erythroid 2-related factor 2 (Nrf2)/heme oxygenase 1 (HO-1) pathway.</description><identifier>ISSN: 1942-0900</identifier><identifier>EISSN: 1942-0994</identifier><identifier>DOI: 10.1155/2018/8487248</identifier><identifier>PMID: 30013722</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Publishing Corporation</publisher><subject>Antioxidants ; Apoptosis ; Chemotherapy ; Cisplatin ; Deoxyribonucleic acid ; DNA ; Ethylenediaminetetraacetic acid ; Hormones ; Inflammation ; Lipid peroxidation ; Lipids ; Medicine, Botanic ; Medicine, Herbal ; Oxidative stress ; Pituitary hormones ; Proteins ; Rodents ; Superoxide ; Testosterone</subject><ispartof>Oxidative medicine and cellular longevity, 2018-01, Vol.2018 (2018), p.1-11</ispartof><rights>Copyright © 2018 Rafa S. Almeer and Ahmed E. Abdel Moneim.</rights><rights>COPYRIGHT 2018 John Wiley & Sons, Inc.</rights><rights>Copyright © 2018 Rafa S. Almeer and Ahmed E. Abdel Moneim. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. http://creativecommons.org/licenses/by/4.0</rights><rights>Copyright © 2018 Rafa S. Almeer and Ahmed E. Abdel Moneim. 2018</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c565t-987b6b7683ef5fa429a5e96ce1dd50d04b26c2d518af2cd9b5e70cf05524d7873</citedby><cites>FETCH-LOGICAL-c565t-987b6b7683ef5fa429a5e96ce1dd50d04b26c2d518af2cd9b5e70cf05524d7873</cites><orcidid>0000-0002-1624-3109 ; 0000-0002-2654-2591</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6022323/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6022323/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30013722$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Banerjee, Jaideep</contributor><creatorcontrib>Almeer, Rafa</creatorcontrib><creatorcontrib>Abdel Moneim, Ahmed E.</creatorcontrib><title>Evaluation of the Protective Effect of Olive Leaf Extract on Cisplatin-Induced Testicular Damage in Rats</title><title>Oxidative medicine and cellular longevity</title><addtitle>Oxid Med Cell Longev</addtitle><description>In the present investigation, the effect of olive leaf extract (OLE) on testicular damage induced in rats by an intraperitoneal injection of cisplatin (cis-diamminedichloroplatinum (CDDP)) at a dose of 5 mg/kg was tested. Rats were randomly divided into 4 groups: control, CDDP, OLE, and OLE + CDDP. After 5 days of CDDP treatment, body and testicular weights, histopathological alteration, and serum male sex hormone levels were determined. In addition to the biochemical and immunohistochemical changes in the testes, CDDP caused the disorganization of germinal epithelium and apoptosis by inducing Bax and inhibiting Bcl-2 protein expression. Testicular weights, catalase, serum testosterone, testicular enzymatic (including glutathione peroxidase, glutathione reductase, and superoxide dismutase) along with nonenzymatic (glutathione) antioxidants, and levels of luteinizing and follicle-stimulating hormones were significantly reduced in addition to a significant increase in testicular malondialdehyde and nitrite/nitrate levels when compared with the control group. OLE treatment markedly attenuated both biochemical and histopathological changes. The reproductive beneficial effects of OLE were mediated, at least partly, by inducing the nuclear factor erythroid 2-related factor 2 (Nrf2)/heme oxygenase 1 (HO-1) pathway.</description><subject>Antioxidants</subject><subject>Apoptosis</subject><subject>Chemotherapy</subject><subject>Cisplatin</subject><subject>Deoxyribonucleic acid</subject><subject>DNA</subject><subject>Ethylenediaminetetraacetic acid</subject><subject>Hormones</subject><subject>Inflammation</subject><subject>Lipid peroxidation</subject><subject>Lipids</subject><subject>Medicine, Botanic</subject><subject>Medicine, Herbal</subject><subject>Oxidative stress</subject><subject>Pituitary hormones</subject><subject>Proteins</subject><subject>Rodents</subject><subject>Superoxide</subject><subject>Testosterone</subject><issn>1942-0900</issn><issn>1942-0994</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>RHX</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqNkc1vEzEQxVcIREvhxhlZ4oIES_259l6QqhCgUqQiVM6W1x4nrjZ2WO8G-O_xKiEFTpw89vz8PM-vqp4T_JYQIS4pJupScSUpVw-qc9JyWuO25Q9PNcZn1ZOc7zBuGOXkcXXGMCZMUnpebZZ7009mDCmi5NG4AfR5SCPYMewBLb0v1dy46ef9CoxHyx_jYObTiBYh7_pyOdbX0U0WHLqFPAY79WZA783WrAGFiL6YMT-tHnnTZ3h2XC-qrx-Wt4tP9erm4_XialVb0YixbpXsmk42ioEX3nDaGgFtY4E4J7DDvKONpU4QZTy1ru0ESGw9FoJyJ5VkF9W7g-5u6rbgLMQyba93Q9ia4adOJui_OzFs9DrtdYMpZZQVgVdHgSF9m4odvQ3ZQt-bCGnKmmJJhGRUtAV9-Q96l6YhFnuFYoKSVil8T61NDzpEn-b_m0X1VXlUEsmxKNSbA2WHlPMA_jQywXoOWs9B62PQBX_xp80T_DvZArw-AJsQnfke_lMOCgPe3NOUFDHOfgE_Vrj0</recordid><startdate>20180101</startdate><enddate>20180101</enddate><creator>Almeer, Rafa</creator><creator>Abdel Moneim, Ahmed E.</creator><general>Hindawi Publishing Corporation</general><general>Hindawi</general><general>John Wiley & Sons, Inc</general><general>Hindawi Limited</general><scope>ADJCN</scope><scope>AHFXO</scope><scope>RHU</scope><scope>RHW</scope><scope>RHX</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-1624-3109</orcidid><orcidid>https://orcid.org/0000-0002-2654-2591</orcidid></search><sort><creationdate>20180101</creationdate><title>Evaluation of the Protective Effect of Olive Leaf Extract on Cisplatin-Induced Testicular Damage in Rats</title><author>Almeer, Rafa ; 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| source | Wiley Online Library Open Access; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Alma/SFX Local Collection; PubMed Central Open Access |
| subjects | Antioxidants Apoptosis Chemotherapy Cisplatin Deoxyribonucleic acid DNA Ethylenediaminetetraacetic acid Hormones Inflammation Lipid peroxidation Lipids Medicine, Botanic Medicine, Herbal Oxidative stress Pituitary hormones Proteins Rodents Superoxide Testosterone |
| title | Evaluation of the Protective Effect of Olive Leaf Extract on Cisplatin-Induced Testicular Damage in Rats |
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