Cutaneous malignant melanoma in two rabbits (Oryctolagus cuniculus)
Despite being rarely reported, improved diagnostic and prognostic indicators are necessary for treating malignant melanoma in rabbits. In this study, two cases of primary skin lesions, on the scrotum and on eyelid, with systemic metastases, were examined. The tumors formed intra-dermally by sheet-li...
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| Veröffentlicht in: | Journal of Veterinary Medical Science 2018, Vol.80(6), pp.973-976 |
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| creator | UEDA, Kengo UEDA, Akiko OZAKI, Kiyokazu |
| description | Despite being rarely reported, improved diagnostic and prognostic indicators are necessary for treating malignant melanoma in rabbits. In this study, two cases of primary skin lesions, on the scrotum and on eyelid, with systemic metastases, were examined. The tumors formed intra-dermally by sheet-like proliferation of polymorphic cells, with anisocytosis and varying amount of melanin granules. Tumors had displaced almost 50% of the lung and liver tissue, and tumor metastasis was the cause of early death in both rabbits. Ki-67-positive population was high in both, and it was found to be useful in assessing the outcome and malignancy. In addition, Melan-A, HMB-45, PNL2 and S100 established a useful immunohistochemical panel for the diagnosis of melanocytic tumor in rabbits. |
| doi_str_mv | 10.1292/jvms.18-0081 |
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In this study, two cases of primary skin lesions, on the scrotum and on eyelid, with systemic metastases, were examined. The tumors formed intra-dermally by sheet-like proliferation of polymorphic cells, with anisocytosis and varying amount of melanin granules. Tumors had displaced almost 50% of the lung and liver tissue, and tumor metastasis was the cause of early death in both rabbits. Ki-67-positive population was high in both, and it was found to be useful in assessing the outcome and malignancy. In addition, Melan-A, HMB-45, PNL2 and S100 established a useful immunohistochemical panel for the diagnosis of melanocytic tumor in rabbits.</description><identifier>ISSN: 0916-7250</identifier><identifier>EISSN: 1347-7439</identifier><identifier>DOI: 10.1292/jvms.18-0081</identifier><identifier>PMID: 29681558</identifier><language>eng</language><publisher>Japan: JAPANESE SOCIETY OF VETERINARY SCIENCE</publisher><subject>Animals ; Biomarkers, Tumor ; Fatal Outcome ; Immunohistochemistry - veterinary ; Ki-67 ; Male ; melanoma ; Melanoma - veterinary ; Neoplasm Proteins ; Pathology ; rabbit ; Rabbits ; skin ; Skin Neoplasms - veterinary</subject><ispartof>Journal of Veterinary Medical Science, 2018, Vol.80(6), pp.973-976</ispartof><rights>2018 by the Japanese Society of Veterinary Science</rights><rights>2018 The Japanese Society of Veterinary Science 2018</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c678t-bc3a5a1e4160d55d15ef2fee720e3e3965619c2c998d5e1e1c231e3c7f66be623</citedby><cites>FETCH-LOGICAL-c678t-bc3a5a1e4160d55d15ef2fee720e3e3965619c2c998d5e1e1c231e3c7f66be623</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6021888/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6021888/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,1883,4024,27923,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29681558$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>UEDA, Kengo</creatorcontrib><creatorcontrib>UEDA, Akiko</creatorcontrib><creatorcontrib>OZAKI, Kiyokazu</creatorcontrib><title>Cutaneous malignant melanoma in two rabbits (Oryctolagus cuniculus)</title><title>Journal of Veterinary Medical Science</title><addtitle>J. Vet. Med. Sci.</addtitle><description>Despite being rarely reported, improved diagnostic and prognostic indicators are necessary for treating malignant melanoma in rabbits. In this study, two cases of primary skin lesions, on the scrotum and on eyelid, with systemic metastases, were examined. The tumors formed intra-dermally by sheet-like proliferation of polymorphic cells, with anisocytosis and varying amount of melanin granules. Tumors had displaced almost 50% of the lung and liver tissue, and tumor metastasis was the cause of early death in both rabbits. Ki-67-positive population was high in both, and it was found to be useful in assessing the outcome and malignancy. In addition, Melan-A, HMB-45, PNL2 and S100 established a useful immunohistochemical panel for the diagnosis of melanocytic tumor in rabbits.</description><subject>Animals</subject><subject>Biomarkers, Tumor</subject><subject>Fatal Outcome</subject><subject>Immunohistochemistry - veterinary</subject><subject>Ki-67</subject><subject>Male</subject><subject>melanoma</subject><subject>Melanoma - veterinary</subject><subject>Neoplasm Proteins</subject><subject>Pathology</subject><subject>rabbit</subject><subject>Rabbits</subject><subject>skin</subject><subject>Skin Neoplasms - veterinary</subject><issn>0916-7250</issn><issn>1347-7439</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkEFPHCEUgElTU1fbW89mjjZxlAcLA5cmurHVxMRLeyYM-2ZlwzAKjMZ_39nMdtNe4PC-fDw-Qr4CvQSm2dX2tc-XoGpKFXwgC-DLpm6WXH8kC6pB1g0T9Jic5LyllMFS6k_kmGmpQAi1IKvVWGzEYcxVb4PfRBtL1WOwceht5WNV3oYq2bb1JVfnj-ndlSHYzYS7MXo3hjF_-0yOOhsyftnfp-T3j9tfq7v64fHn_er6oXayUaVuHbfCAi5B0rUQaxDYsQ6xYRQ5ci2FBO2Y01qtBQKCYxyQu6aTskXJ-Cn5Pnufx7bHtcNYkg3mOfnepnczWG_-n0T_ZDbDq5HTx5VSk-B8L0jDy4i5mN5nhyHMBQyjUxiupz0m9GJGXRpyTtgdngFqdt3NrrsBZXbdJ_zs39UO8N_QE3AzA9tc7AYPgE3Fu4CzTVEjd8feehi6J5sMRv4H9UOYaw</recordid><startdate>2018</startdate><enddate>2018</enddate><creator>UEDA, Kengo</creator><creator>UEDA, Akiko</creator><creator>OZAKI, Kiyokazu</creator><general>JAPANESE SOCIETY OF VETERINARY SCIENCE</general><general>The Japanese Society of Veterinary Science</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>2018</creationdate><title>Cutaneous malignant melanoma in two rabbits (Oryctolagus cuniculus)</title><author>UEDA, Kengo ; UEDA, Akiko ; OZAKI, Kiyokazu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c678t-bc3a5a1e4160d55d15ef2fee720e3e3965619c2c998d5e1e1c231e3c7f66be623</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Animals</topic><topic>Biomarkers, Tumor</topic><topic>Fatal Outcome</topic><topic>Immunohistochemistry - veterinary</topic><topic>Ki-67</topic><topic>Male</topic><topic>melanoma</topic><topic>Melanoma - veterinary</topic><topic>Neoplasm Proteins</topic><topic>Pathology</topic><topic>rabbit</topic><topic>Rabbits</topic><topic>skin</topic><topic>Skin Neoplasms - veterinary</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>UEDA, Kengo</creatorcontrib><creatorcontrib>UEDA, Akiko</creatorcontrib><creatorcontrib>OZAKI, Kiyokazu</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of Veterinary Medical Science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>UEDA, Kengo</au><au>UEDA, Akiko</au><au>OZAKI, Kiyokazu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cutaneous malignant melanoma in two rabbits (Oryctolagus cuniculus)</atitle><jtitle>Journal of Veterinary Medical Science</jtitle><addtitle>J. Vet. Med. Sci.</addtitle><date>2018</date><risdate>2018</risdate><volume>80</volume><issue>6</issue><spage>973</spage><epage>976</epage><pages>973-976</pages><issn>0916-7250</issn><eissn>1347-7439</eissn><abstract>Despite being rarely reported, improved diagnostic and prognostic indicators are necessary for treating malignant melanoma in rabbits. In this study, two cases of primary skin lesions, on the scrotum and on eyelid, with systemic metastases, were examined. The tumors formed intra-dermally by sheet-like proliferation of polymorphic cells, with anisocytosis and varying amount of melanin granules. Tumors had displaced almost 50% of the lung and liver tissue, and tumor metastasis was the cause of early death in both rabbits. Ki-67-positive population was high in both, and it was found to be useful in assessing the outcome and malignancy. In addition, Melan-A, HMB-45, PNL2 and S100 established a useful immunohistochemical panel for the diagnosis of melanocytic tumor in rabbits.</abstract><cop>Japan</cop><pub>JAPANESE SOCIETY OF VETERINARY SCIENCE</pub><pmid>29681558</pmid><doi>10.1292/jvms.18-0081</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| source | J-STAGE Free; MEDLINE; PubMed Central Open Access; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Animals Biomarkers, Tumor Fatal Outcome Immunohistochemistry - veterinary Ki-67 Male melanoma Melanoma - veterinary Neoplasm Proteins Pathology rabbit Rabbits skin Skin Neoplasms - veterinary |
| title | Cutaneous malignant melanoma in two rabbits (Oryctolagus cuniculus) |
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