Near diffusion-controlled reaction of a Zn(Cys) 4 zinc finger with hypochlorous acid

Hypochlorous acid (HOCl) is one of the strongest oxidants produced in mammals to kill invading microorganisms. The bacterial response to HOCl involves proteins that are able to sense HOCl using methionine, free cysteines or zinc-bound cysteines of zinc finger sites. Although the reactivity of methio...

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Veröffentlicht in:	Chemical science (Cambridge) 2016, Vol.7 (8), p.5508-5516
Hauptverfasser:	Lebrun, Vincent, Ravanat, Jean-Luc, Latour, Jean-Marc, Sénèque, Olivier
Format:	Artikel
Sprache:	eng
Schlagworte:	Bacteria Chemical Sciences Chemistry Cysteine Fingers Methionine Oxidation Proteins Rate constants Zinc
Online-Zugang:	Volltext
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