Six novel susceptibility loci for coronary artery disease and cerebral infarction identified by longitudinal exome-wide association studies in a Japanese population

Coronary artery disease (CAD) and cerebral infarction (CI) remain major causes of morbidity and mortality in humans. Recent genome-wide association studies have identified various genetic variants associated with these diseases. However, these studies were commonly conducted in a cross-sectional man...

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Veröffentlicht in:	Biomedical reports 2018-08, Vol.9 (2), p.123-134
Hauptverfasser:	Yasukochi, Yoshiki, Sakuma, Jun, Takeuchi, Ichiro, Kato, Kimihiko, Oguri, Mitsutoshi, Fujimaki, Tetsuo, Horibe, Hideki, Yamada, Yoshiji
Format:	Artikel
Sprache:	eng
Schlagworte:	Brain diseases Cardiovascular disease Cerebral infarction Chromosomes Coronary artery Coronary artery disease Coronary heart disease Coronary vessels Cultural differences Deoxyribonucleic acid DNA Genetic aspects Genetic diversity Genetic testing Genetic variation Genome-wide association studies Genomes Genomics Genotype & phenotype Heart attacks Heart diseases Heredity Infarction Loci Mathematical models Minority & ethnic groups Mitochondrial DNA Morbidity Mortality Osteoprotegerin Patient outcomes Physiology Population Population (statistical) Principal components analysis Quality control Risk factors Single-nucleotide polymorphism Stroke Studies
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