Specific Frontostriatal Circuits for Impaired Cognitive Flexibility and Goal-Directed Planning in Obsessive-Compulsive Disorder: Evidence From Resting-State Functional Connectivity

Abstract Background A recent hypothesis has suggested that core deficits in goal-directed behavior in obsessive-compulsive disorder (OCD) are caused by impaired frontostriatal function. We tested this hypothesis in OCD patients and control subjects by relating measures of goal-directed planning and...

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Veröffentlicht in:	Biological psychiatry (1969) 2017-04, Vol.81 (8), p.708-717
Hauptverfasser:	Vaghi, Matilde M, Vértes, Petra E, Kitzbichler, Manfred G, Apergis-Schoute, Annemieke M, van der Flier, Febe E, Fineberg, Naomi A, Sule, Akeem, Zaman, Rashid, Voon, Valerie, Kundu, Prantik, Bullmore, Edward T, Robbins, Trevor W
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Attention - physiology Brain Mapping Cognition - physiology Cognitive flexibility Corpus Striatum - physiopathology Executive Function - physiology Female Frontostriatal circuits Functional connectivity Goal-directed planning Goals Humans Magnetic Resonance Imaging Male Neural Pathways - physiopathology Obsessive-compulsive disorder Obsessive-Compulsive Disorder - physiopathology Prefrontal Cortex - physiopathology Psychiatry Resting state Severity of Illness Index
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