Flow-induced deformation in a microchannel with a non-Newtonian fluid
In this work, we have fabricated physiologically relevant polydimethylsiloxane microfluidic phantoms to investigate the fluid-structure interaction that arises from the interaction between a non-Newtonian fluid and the deformable wall. A shear thinning fluid (Xanthan gum solution) is used as the blo...
Gespeichert in:
| Veröffentlicht in: | Biomicrofluidics 2018-05, Vol.12 (3), p.034116-034116 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 034116 |
|---|---|
| container_issue | 3 |
| container_start_page | 034116 |
| container_title | Biomicrofluidics |
| container_volume | 12 |
| creator | Raj M, Kiran Chakraborty, Jeevanjyoti DasGupta, Sunando Chakraborty, Suman |
| description | In this work, we have fabricated physiologically relevant polydimethylsiloxane
microfluidic phantoms to investigate the fluid-structure interaction that arises from the
interaction between a non-Newtonian fluid and the deformable wall. A shear thinning fluid
(Xanthan gum solution) is used as the blood analog fluid. We have systematically analyzed
the steady flow characteristics of the microfluidic phantom using pressure drop,
deformation, and flow visualization using micro-PIV (Particle Image Velocimetry) to
identify the intricate aspects of the pressure as well as the velocity field. A simple
mathematical formulation is introduced to evaluate the flow induced deformation. These
results will aid in the design and development of deformable microfluidic systems and
provide a deeper understanding of the fluid-structure interaction in microchannels with
special emphasis on biomimetic in-vitro models for lab-on-a-chip
applications. |
| doi_str_mv | 10.1063/1.5036632 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6019333</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2071576831</sourcerecordid><originalsourceid>FETCH-LOGICAL-c445t-2bb35e38aa8766777c9189f04a71f0d84063ebb243734b856d2ae36c0446c27e3</originalsourceid><addsrcrecordid>eNp9kE9PwyAYh4nRuDk9-AVMj2rSyb9CdzExy6Ymi170TChQh2lhlnaL3150c86DcnkJ75Pf-_IAcIrgEEFGrtAwg4QxgvdAH40IThHM8v2dew8chfAKYYY4xoegRyBEORtlfTCZVn6VWqc7ZXSiTembWrbWu8S6RCa1VY1Xc-mcqZKVbefxzXmXPphV652VLimrzupjcFDKKpiTTR2A5-nkaXyXzh5v78c3s1RRmrUpLgqSGZJLmXPGOOdqhPJRCankqIQ6p_EzpigwJZzQIs-YxtIQpiClTGFuyABcr3MXXVEbrYxrG1mJRWNr2bwLL6343XF2Ll78UjAYXcQzAOebgMa_dSa0orZBmaqSzvguCAw5yjjLCYroxRqNBkJoTLkdg6D41C6Q2GiP7NnuXlvy23MELtdAULb98vtv2p_w0jc_oFjoknwAGt2YrQ</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2071576831</pqid></control><display><type>article</type><title>Flow-induced deformation in a microchannel with a non-Newtonian fluid</title><source>AIP Journals Complete</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><creator>Raj M, Kiran ; Chakraborty, Jeevanjyoti ; DasGupta, Sunando ; Chakraborty, Suman</creator><creatorcontrib>Raj M, Kiran ; Chakraborty, Jeevanjyoti ; DasGupta, Sunando ; Chakraborty, Suman</creatorcontrib><description>In this work, we have fabricated physiologically relevant polydimethylsiloxane
microfluidic phantoms to investigate the fluid-structure interaction that arises from the
interaction between a non-Newtonian fluid and the deformable wall. A shear thinning fluid
(Xanthan gum solution) is used as the blood analog fluid. We have systematically analyzed
the steady flow characteristics of the microfluidic phantom using pressure drop,
deformation, and flow visualization using micro-PIV (Particle Image Velocimetry) to
identify the intricate aspects of the pressure as well as the velocity field. A simple
mathematical formulation is introduced to evaluate the flow induced deformation. These
results will aid in the design and development of deformable microfluidic systems and
provide a deeper understanding of the fluid-structure interaction in microchannels with
special emphasis on biomimetic in-vitro models for lab-on-a-chip
applications.</description><identifier>ISSN: 1932-1058</identifier><identifier>EISSN: 1932-1058</identifier><identifier>DOI: 10.1063/1.5036632</identifier><identifier>PMID: 30018695</identifier><identifier>CODEN: BIOMGB</identifier><language>eng</language><publisher>United States: AIP Publishing LLC</publisher><subject>Regular</subject><ispartof>Biomicrofluidics, 2018-05, Vol.12 (3), p.034116-034116</ispartof><rights>Author(s)</rights><rights>Copyright © 2018 Author(s) 2018 Author(s)</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c445t-2bb35e38aa8766777c9189f04a71f0d84063ebb243734b856d2ae36c0446c27e3</citedby><cites>FETCH-LOGICAL-c445t-2bb35e38aa8766777c9189f04a71f0d84063ebb243734b856d2ae36c0446c27e3</cites><orcidid>0000-0002-5454-9766 ; 0000-0003-0403-8447</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6019333/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://pubs.aip.org/bmf/article-lookup/doi/10.1063/1.5036632$$EHTML$$P50$$Gscitation$$H</linktohtml><link.rule.ids>230,314,727,780,784,794,885,4512,27924,27925,53791,53793,76384</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30018695$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Raj M, Kiran</creatorcontrib><creatorcontrib>Chakraborty, Jeevanjyoti</creatorcontrib><creatorcontrib>DasGupta, Sunando</creatorcontrib><creatorcontrib>Chakraborty, Suman</creatorcontrib><title>Flow-induced deformation in a microchannel with a non-Newtonian fluid</title><title>Biomicrofluidics</title><addtitle>Biomicrofluidics</addtitle><description>In this work, we have fabricated physiologically relevant polydimethylsiloxane
microfluidic phantoms to investigate the fluid-structure interaction that arises from the
interaction between a non-Newtonian fluid and the deformable wall. A shear thinning fluid
(Xanthan gum solution) is used as the blood analog fluid. We have systematically analyzed
the steady flow characteristics of the microfluidic phantom using pressure drop,
deformation, and flow visualization using micro-PIV (Particle Image Velocimetry) to
identify the intricate aspects of the pressure as well as the velocity field. A simple
mathematical formulation is introduced to evaluate the flow induced deformation. These
results will aid in the design and development of deformable microfluidic systems and
provide a deeper understanding of the fluid-structure interaction in microchannels with
special emphasis on biomimetic in-vitro models for lab-on-a-chip
applications.</description><subject>Regular</subject><issn>1932-1058</issn><issn>1932-1058</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNp9kE9PwyAYh4nRuDk9-AVMj2rSyb9CdzExy6Ymi170TChQh2lhlnaL3150c86DcnkJ75Pf-_IAcIrgEEFGrtAwg4QxgvdAH40IThHM8v2dew8chfAKYYY4xoegRyBEORtlfTCZVn6VWqc7ZXSiTembWrbWu8S6RCa1VY1Xc-mcqZKVbefxzXmXPphV652VLimrzupjcFDKKpiTTR2A5-nkaXyXzh5v78c3s1RRmrUpLgqSGZJLmXPGOOdqhPJRCankqIQ6p_EzpigwJZzQIs-YxtIQpiClTGFuyABcr3MXXVEbrYxrG1mJRWNr2bwLL6343XF2Ll78UjAYXcQzAOebgMa_dSa0orZBmaqSzvguCAw5yjjLCYroxRqNBkJoTLkdg6D41C6Q2GiP7NnuXlvy23MELtdAULb98vtv2p_w0jc_oFjoknwAGt2YrQ</recordid><startdate>20180501</startdate><enddate>20180501</enddate><creator>Raj M, Kiran</creator><creator>Chakraborty, Jeevanjyoti</creator><creator>DasGupta, Sunando</creator><creator>Chakraborty, Suman</creator><general>AIP Publishing LLC</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-5454-9766</orcidid><orcidid>https://orcid.org/0000-0003-0403-8447</orcidid></search><sort><creationdate>20180501</creationdate><title>Flow-induced deformation in a microchannel with a non-Newtonian fluid</title><author>Raj M, Kiran ; Chakraborty, Jeevanjyoti ; DasGupta, Sunando ; Chakraborty, Suman</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c445t-2bb35e38aa8766777c9189f04a71f0d84063ebb243734b856d2ae36c0446c27e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Regular</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Raj M, Kiran</creatorcontrib><creatorcontrib>Chakraborty, Jeevanjyoti</creatorcontrib><creatorcontrib>DasGupta, Sunando</creatorcontrib><creatorcontrib>Chakraborty, Suman</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Biomicrofluidics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Raj M, Kiran</au><au>Chakraborty, Jeevanjyoti</au><au>DasGupta, Sunando</au><au>Chakraborty, Suman</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Flow-induced deformation in a microchannel with a non-Newtonian fluid</atitle><jtitle>Biomicrofluidics</jtitle><addtitle>Biomicrofluidics</addtitle><date>2018-05-01</date><risdate>2018</risdate><volume>12</volume><issue>3</issue><spage>034116</spage><epage>034116</epage><pages>034116-034116</pages><issn>1932-1058</issn><eissn>1932-1058</eissn><coden>BIOMGB</coden><abstract>In this work, we have fabricated physiologically relevant polydimethylsiloxane
microfluidic phantoms to investigate the fluid-structure interaction that arises from the
interaction between a non-Newtonian fluid and the deformable wall. A shear thinning fluid
(Xanthan gum solution) is used as the blood analog fluid. We have systematically analyzed
the steady flow characteristics of the microfluidic phantom using pressure drop,
deformation, and flow visualization using micro-PIV (Particle Image Velocimetry) to
identify the intricate aspects of the pressure as well as the velocity field. A simple
mathematical formulation is introduced to evaluate the flow induced deformation. These
results will aid in the design and development of deformable microfluidic systems and
provide a deeper understanding of the fluid-structure interaction in microchannels with
special emphasis on biomimetic in-vitro models for lab-on-a-chip
applications.</abstract><cop>United States</cop><pub>AIP Publishing LLC</pub><pmid>30018695</pmid><doi>10.1063/1.5036632</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0002-5454-9766</orcidid><orcidid>https://orcid.org/0000-0003-0403-8447</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-1058 |
| ispartof | Biomicrofluidics, 2018-05, Vol.12 (3), p.034116-034116 |
| issn | 1932-1058 1932-1058 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6019333 |
| source | AIP Journals Complete; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Regular |
| title | Flow-induced deformation in a microchannel with a non-Newtonian fluid |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-20T12%3A40%3A06IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Flow-induced%20deformation%20in%20a%20microchannel%20with%20a%20non-Newtonian%20fluid&rft.jtitle=Biomicrofluidics&rft.au=Raj%20M,%20Kiran&rft.date=2018-05-01&rft.volume=12&rft.issue=3&rft.spage=034116&rft.epage=034116&rft.pages=034116-034116&rft.issn=1932-1058&rft.eissn=1932-1058&rft.coden=BIOMGB&rft_id=info:doi/10.1063/1.5036632&rft_dat=%3Cproquest_pubme%3E2071576831%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2071576831&rft_id=info:pmid/30018695&rfr_iscdi=true |