Antimicrobial and Antibiofilm Activity of Human Milk Oligosaccharides against Streptococcus agalactiae, Staphylococcus aureus, and Acinetobacter baumannii

In a previous study, we reported that human milk oligosaccharides (HMOs) isolated from five donor milk samples possessed antimicrobial and antibiofilm activity against Streptococcus agalactiae, also known as Group B Streptococcus or GBS. Herein, we present a broader evaluation of the antimicrobial a...

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Veröffentlicht in:	ACS infectious diseases 2018-03, Vol.4 (3), p.315-324
Hauptverfasser:	Ackerman, Dorothy L, Craft, Kelly M, Doster, Ryan S, Weitkamp, Jörn-Hendrik, Aronoff, David M, Gaddy, Jennifer A, Townsend, Steven D
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Sprache:	eng
Schlagworte:	Acinetobacter baumannii - drug effects Acinetobacter baumannii - growth & development Anti-Bacterial Agents - isolation & purification Anti-Bacterial Agents - pharmacology Biofilms - drug effects Biofilms - growth & development Biological Products - isolation & purification Biological Products - pharmacology Female Humans Microbial Sensitivity Tests Milk, Human - chemistry Oligosaccharides - isolation & purification Oligosaccharides - pharmacology Staphylococcus aureus - drug effects Staphylococcus aureus - growth & development Streptococcus agalactiae - drug effects Streptococcus agalactiae - growth & development
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description	In a previous study, we reported that human milk oligosaccharides (HMOs) isolated from five donor milk samples possessed antimicrobial and antibiofilm activity against Streptococcus agalactiae, also known as Group B Streptococcus or GBS. Herein, we present a broader evaluation of the antimicrobial and antibiofilm activity by screening HMOs from 14 new donors against three strains of GBS and two of the ESKAPE pathogens of particular interest to child health, Staphylococcus aureus and Acinetobacter baumannii. Growth and biofilm assays showed that HMOs from these new donors possessed antimicrobial and antibiofilm activity against all three strains of GBS, antibiofilm activity against methicillin-resistant S. aureus strain USA300, and antimicrobial activity against A. baumannii strain ATCC 19606.
doi_str_mv	10.1021/acsinfecdis.7b00183
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Dis</addtitle><description>In a previous study, we reported that human milk oligosaccharides (HMOs) isolated from five donor milk samples possessed antimicrobial and antibiofilm activity against Streptococcus agalactiae, also known as Group B Streptococcus or GBS. Herein, we present a broader evaluation of the antimicrobial and antibiofilm activity by screening HMOs from 14 new donors against three strains of GBS and two of the ESKAPE pathogens of particular interest to child health, Staphylococcus aureus and Acinetobacter baumannii. 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subjects	Acinetobacter baumannii - drug effects Acinetobacter baumannii - growth & development Anti-Bacterial Agents - isolation & purification Anti-Bacterial Agents - pharmacology Biofilms - drug effects Biofilms - growth & development Biological Products - isolation & purification Biological Products - pharmacology Female Humans Microbial Sensitivity Tests Milk, Human - chemistry Oligosaccharides - isolation & purification Oligosaccharides - pharmacology Staphylococcus aureus - drug effects Staphylococcus aureus - growth & development Streptococcus agalactiae - drug effects Streptococcus agalactiae - growth & development
title	Antimicrobial and Antibiofilm Activity of Human Milk Oligosaccharides against Streptococcus agalactiae, Staphylococcus aureus, and Acinetobacter baumannii
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