Th17 cells differentiated with mycelial membranes of Candida albicans prevent oral candidiasis
Candida albicans is a human commensal that causes opportunistic infections. Th17 cells provide resistance against mucosal infection with C. albicans; however, the T cell antigens remain little known. Our final goal is to find effective T cell antigens of C. albicans that are responsible for immunoth...
Gespeichert in:
| Veröffentlicht in: | FEMS yeast research 2018-05, Vol.18 (3), p.1 |
|---|---|
| Hauptverfasser: | , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | 3 |
| container_start_page | 1 |
| container_title | FEMS yeast research |
| container_volume | 18 |
| creator | Tasaki, Sonoko Cho, Tamaki Nagao, Jun-Ichi Ikezaki, Shojiro Narita, Yuka Arita-Morioka, Ken-Ichi Yasumatsu, Kanae Toyoda, Keita Kojima, Hiroshi Tanaka, Yoshihiko |
| description | Candida albicans is a human commensal that causes opportunistic infections. Th17 cells provide resistance against mucosal infection with C. albicans; however, the T cell antigens remain little known. Our final goal is to find effective T cell antigens of C. albicans that are responsible for immunotherapy against candidiasis. Here, we prepared fractions including cytosol, membrane and cell wall from yeast and mycelial cells. Proteins derived from a membrane fraction of mycelial cells effectively induced differentiation of CD4+ T cells into IL-17A-producing Th17 cells. To confirm the immunological response in vivo of proteins from mycelial membrane, we performed adoptive transfer experiments using ex vivo stimulated CD4+ T cells from IL-17A-GFP reporter mice. Mycelial membrane-differentiated CD4+ Th17 cells adoptively transferred intravenously prevented oral candidiasis by oral infection of C. albicans, compared with control anti-CD3-stimulated CD4+ T cells. This was confirmed by the clinical score and the number of neutrophils on the infected tissues. These data suggest that effective T cell antigens against candidiasis could be present in the membrane protein fraction of mycelial cells. The design of novel vaccination strategies against candidiasis will be our next step. |
| doi_str_mv | 10.1093/femsyr/foy018 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6019029</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A702388028</galeid><sourcerecordid>A702388028</sourcerecordid><originalsourceid>FETCH-LOGICAL-c549t-fb154d703dac787b4420e132eb7abbda0e1cfec806f5dd94cea288021e76ebde3</originalsourceid><addsrcrecordid>eNqFkstv1DAQxiMEoqVw5IoscYFD2vEjcXJBqlY8KlVCgnLFcuzxrqskXuyksP89DltKFyFhH_yY34zHn76ieE7hlELLzxwOaRfPXNgBbR4Ux7SqZUl5LR7e2x8VT1K6BqASoHlcHLFW1Iy1zXHx9WpDJTHY94lY7xxGHCevJ7Tku582ZNjlmNc9GXDooh4xkeDISo_WW01033mjx0S2EW9yIgkxo-ZX1Ovk09PikdN9wme360nx5d3bq9WH8vLj-4vV-WVpKtFOpetoJawEbrWRjeyEYICUM-yk7jqr88E4NA3UrrK2FQY1axpgFGWNnUV-UrzZ193O3YDW5F5yJ2ob_aDjTgXt1WFk9Bu1DjeqBtoCa3OBV7cFYvg2Y5rU4NMiS_5ymJNinFcUKtk0_0cBJKVCVjyjL_9Cr8Mcx6yEYgLy4ELWf6i17lH50YXcolmKqnMJjC8_XZ49_QeVp8XBmzCi8_n-IOH1QUJmJvwxrfWckrr4_OmQLfesiSGliO5OOgpq8Zna-0ztfZb5F_f1vqN_G4v_BOnez-0</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2400003476</pqid></control><display><type>article</type><title>Th17 cells differentiated with mycelial membranes of Candida albicans prevent oral candidiasis</title><source>Oxford Journals Open Access Collection</source><source>MEDLINE</source><source>PubMed Central</source><creator>Tasaki, Sonoko ; Cho, Tamaki ; Nagao, Jun-Ichi ; Ikezaki, Shojiro ; Narita, Yuka ; Arita-Morioka, Ken-Ichi ; Yasumatsu, Kanae ; Toyoda, Keita ; Kojima, Hiroshi ; Tanaka, Yoshihiko</creator><creatorcontrib>Tasaki, Sonoko ; Cho, Tamaki ; Nagao, Jun-Ichi ; Ikezaki, Shojiro ; Narita, Yuka ; Arita-Morioka, Ken-Ichi ; Yasumatsu, Kanae ; Toyoda, Keita ; Kojima, Hiroshi ; Tanaka, Yoshihiko</creatorcontrib><description>Candida albicans is a human commensal that causes opportunistic infections. Th17 cells provide resistance against mucosal infection with C. albicans; however, the T cell antigens remain little known. Our final goal is to find effective T cell antigens of C. albicans that are responsible for immunotherapy against candidiasis. Here, we prepared fractions including cytosol, membrane and cell wall from yeast and mycelial cells. Proteins derived from a membrane fraction of mycelial cells effectively induced differentiation of CD4+ T cells into IL-17A-producing Th17 cells. To confirm the immunological response in vivo of proteins from mycelial membrane, we performed adoptive transfer experiments using ex vivo stimulated CD4+ T cells from IL-17A-GFP reporter mice. Mycelial membrane-differentiated CD4+ Th17 cells adoptively transferred intravenously prevented oral candidiasis by oral infection of C. albicans, compared with control anti-CD3-stimulated CD4+ T cells. This was confirmed by the clinical score and the number of neutrophils on the infected tissues. These data suggest that effective T cell antigens against candidiasis could be present in the membrane protein fraction of mycelial cells. The design of novel vaccination strategies against candidiasis will be our next step.</description><identifier>ISSN: 1567-1364</identifier><identifier>ISSN: 1567-1356</identifier><identifier>EISSN: 1567-1364</identifier><identifier>DOI: 10.1093/femsyr/foy018</identifier><identifier>PMID: 29462298</identifier><language>eng</language><publisher>England: Oxford University Press</publisher><subject>Adoptive Transfer ; Animals ; Antifungal agents ; Antigens ; Antigens, Fungal - immunology ; Antigens, Fungal - pharmacology ; Candida albicans ; Candida albicans - immunology ; Candidiasis ; Candidiasis, Oral - immunology ; Candidiasis, Oral - prevention & control ; CD3 antigen ; CD4 antigen ; CD4-positive T-lymphocytes ; Cell Differentiation ; Cell walls ; Cytosol ; Female ; Fungal Proteins - immunology ; Fungal Proteins - pharmacology ; Health aspects ; Helper cells ; immune response ; Immunotherapy ; Infection ; intravenous injection ; Leukocytes (neutrophilic) ; Lymphocytes ; Lymphocytes T ; Male ; Membrane proteins ; Mice ; Mice, Inbred C57BL ; Mucosa ; Mycelia ; mycelium ; Mycelium - chemistry ; Mycelium - immunology ; neutrophils ; Oral infection ; Prevention ; Proteins ; secondary infection ; T cells ; Th17 Cells - cytology ; Th17 Cells - immunology ; Thrush (Mouth disease) ; tissues ; Vaccination ; yeasts</subject><ispartof>FEMS yeast research, 2018-05, Vol.18 (3), p.1</ispartof><rights>COPYRIGHT 2018 Oxford University Press</rights><rights>FEMS 2018.</rights><rights>FEMS 2018. 2018</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c549t-fb154d703dac787b4420e132eb7abbda0e1cfec806f5dd94cea288021e76ebde3</citedby><cites>FETCH-LOGICAL-c549t-fb154d703dac787b4420e132eb7abbda0e1cfec806f5dd94cea288021e76ebde3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6019029/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6019029/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29462298$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tasaki, Sonoko</creatorcontrib><creatorcontrib>Cho, Tamaki</creatorcontrib><creatorcontrib>Nagao, Jun-Ichi</creatorcontrib><creatorcontrib>Ikezaki, Shojiro</creatorcontrib><creatorcontrib>Narita, Yuka</creatorcontrib><creatorcontrib>Arita-Morioka, Ken-Ichi</creatorcontrib><creatorcontrib>Yasumatsu, Kanae</creatorcontrib><creatorcontrib>Toyoda, Keita</creatorcontrib><creatorcontrib>Kojima, Hiroshi</creatorcontrib><creatorcontrib>Tanaka, Yoshihiko</creatorcontrib><title>Th17 cells differentiated with mycelial membranes of Candida albicans prevent oral candidiasis</title><title>FEMS yeast research</title><addtitle>FEMS Yeast Res</addtitle><description>Candida albicans is a human commensal that causes opportunistic infections. Th17 cells provide resistance against mucosal infection with C. albicans; however, the T cell antigens remain little known. Our final goal is to find effective T cell antigens of C. albicans that are responsible for immunotherapy against candidiasis. Here, we prepared fractions including cytosol, membrane and cell wall from yeast and mycelial cells. Proteins derived from a membrane fraction of mycelial cells effectively induced differentiation of CD4+ T cells into IL-17A-producing Th17 cells. To confirm the immunological response in vivo of proteins from mycelial membrane, we performed adoptive transfer experiments using ex vivo stimulated CD4+ T cells from IL-17A-GFP reporter mice. Mycelial membrane-differentiated CD4+ Th17 cells adoptively transferred intravenously prevented oral candidiasis by oral infection of C. albicans, compared with control anti-CD3-stimulated CD4+ T cells. This was confirmed by the clinical score and the number of neutrophils on the infected tissues. These data suggest that effective T cell antigens against candidiasis could be present in the membrane protein fraction of mycelial cells. The design of novel vaccination strategies against candidiasis will be our next step.</description><subject>Adoptive Transfer</subject><subject>Animals</subject><subject>Antifungal agents</subject><subject>Antigens</subject><subject>Antigens, Fungal - immunology</subject><subject>Antigens, Fungal - pharmacology</subject><subject>Candida albicans</subject><subject>Candida albicans - immunology</subject><subject>Candidiasis</subject><subject>Candidiasis, Oral - immunology</subject><subject>Candidiasis, Oral - prevention & control</subject><subject>CD3 antigen</subject><subject>CD4 antigen</subject><subject>CD4-positive T-lymphocytes</subject><subject>Cell Differentiation</subject><subject>Cell walls</subject><subject>Cytosol</subject><subject>Female</subject><subject>Fungal Proteins - immunology</subject><subject>Fungal Proteins - pharmacology</subject><subject>Health aspects</subject><subject>Helper cells</subject><subject>immune response</subject><subject>Immunotherapy</subject><subject>Infection</subject><subject>intravenous injection</subject><subject>Leukocytes (neutrophilic)</subject><subject>Lymphocytes</subject><subject>Lymphocytes T</subject><subject>Male</subject><subject>Membrane proteins</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Mucosa</subject><subject>Mycelia</subject><subject>mycelium</subject><subject>Mycelium - chemistry</subject><subject>Mycelium - immunology</subject><subject>neutrophils</subject><subject>Oral infection</subject><subject>Prevention</subject><subject>Proteins</subject><subject>secondary infection</subject><subject>T cells</subject><subject>Th17 Cells - cytology</subject><subject>Th17 Cells - immunology</subject><subject>Thrush (Mouth disease)</subject><subject>tissues</subject><subject>Vaccination</subject><subject>yeasts</subject><issn>1567-1364</issn><issn>1567-1356</issn><issn>1567-1364</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqFkstv1DAQxiMEoqVw5IoscYFD2vEjcXJBqlY8KlVCgnLFcuzxrqskXuyksP89DltKFyFhH_yY34zHn76ieE7hlELLzxwOaRfPXNgBbR4Ux7SqZUl5LR7e2x8VT1K6BqASoHlcHLFW1Iy1zXHx9WpDJTHY94lY7xxGHCevJ7Tku582ZNjlmNc9GXDooh4xkeDISo_WW01033mjx0S2EW9yIgkxo-ZX1Ovk09PikdN9wme360nx5d3bq9WH8vLj-4vV-WVpKtFOpetoJawEbrWRjeyEYICUM-yk7jqr88E4NA3UrrK2FQY1axpgFGWNnUV-UrzZ193O3YDW5F5yJ2ob_aDjTgXt1WFk9Bu1DjeqBtoCa3OBV7cFYvg2Y5rU4NMiS_5ymJNinFcUKtk0_0cBJKVCVjyjL_9Cr8Mcx6yEYgLy4ELWf6i17lH50YXcolmKqnMJjC8_XZ49_QeVp8XBmzCi8_n-IOH1QUJmJvwxrfWckrr4_OmQLfesiSGliO5OOgpq8Zna-0ztfZb5F_f1vqN_G4v_BOnez-0</recordid><startdate>20180501</startdate><enddate>20180501</enddate><creator>Tasaki, Sonoko</creator><creator>Cho, Tamaki</creator><creator>Nagao, Jun-Ichi</creator><creator>Ikezaki, Shojiro</creator><creator>Narita, Yuka</creator><creator>Arita-Morioka, Ken-Ichi</creator><creator>Yasumatsu, Kanae</creator><creator>Toyoda, Keita</creator><creator>Kojima, Hiroshi</creator><creator>Tanaka, Yoshihiko</creator><general>Oxford University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>ISR</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>7S9</scope><scope>L.6</scope><scope>5PM</scope></search><sort><creationdate>20180501</creationdate><title>Th17 cells differentiated with mycelial membranes of Candida albicans prevent oral candidiasis</title><author>Tasaki, Sonoko ; Cho, Tamaki ; Nagao, Jun-Ichi ; Ikezaki, Shojiro ; Narita, Yuka ; Arita-Morioka, Ken-Ichi ; Yasumatsu, Kanae ; Toyoda, Keita ; Kojima, Hiroshi ; Tanaka, Yoshihiko</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c549t-fb154d703dac787b4420e132eb7abbda0e1cfec806f5dd94cea288021e76ebde3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Adoptive Transfer</topic><topic>Animals</topic><topic>Antifungal agents</topic><topic>Antigens</topic><topic>Antigens, Fungal - immunology</topic><topic>Antigens, Fungal - pharmacology</topic><topic>Candida albicans</topic><topic>Candida albicans - immunology</topic><topic>Candidiasis</topic><topic>Candidiasis, Oral - immunology</topic><topic>Candidiasis, Oral - prevention & control</topic><topic>CD3 antigen</topic><topic>CD4 antigen</topic><topic>CD4-positive T-lymphocytes</topic><topic>Cell Differentiation</topic><topic>Cell walls</topic><topic>Cytosol</topic><topic>Female</topic><topic>Fungal Proteins - immunology</topic><topic>Fungal Proteins - pharmacology</topic><topic>Health aspects</topic><topic>Helper cells</topic><topic>immune response</topic><topic>Immunotherapy</topic><topic>Infection</topic><topic>intravenous injection</topic><topic>Leukocytes (neutrophilic)</topic><topic>Lymphocytes</topic><topic>Lymphocytes T</topic><topic>Male</topic><topic>Membrane proteins</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Mucosa</topic><topic>Mycelia</topic><topic>mycelium</topic><topic>Mycelium - chemistry</topic><topic>Mycelium - immunology</topic><topic>neutrophils</topic><topic>Oral infection</topic><topic>Prevention</topic><topic>Proteins</topic><topic>secondary infection</topic><topic>T cells</topic><topic>Th17 Cells - cytology</topic><topic>Th17 Cells - immunology</topic><topic>Thrush (Mouth disease)</topic><topic>tissues</topic><topic>Vaccination</topic><topic>yeasts</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tasaki, Sonoko</creatorcontrib><creatorcontrib>Cho, Tamaki</creatorcontrib><creatorcontrib>Nagao, Jun-Ichi</creatorcontrib><creatorcontrib>Ikezaki, Shojiro</creatorcontrib><creatorcontrib>Narita, Yuka</creatorcontrib><creatorcontrib>Arita-Morioka, Ken-Ichi</creatorcontrib><creatorcontrib>Yasumatsu, Kanae</creatorcontrib><creatorcontrib>Toyoda, Keita</creatorcontrib><creatorcontrib>Kojima, Hiroshi</creatorcontrib><creatorcontrib>Tanaka, Yoshihiko</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>AGRICOLA</collection><collection>AGRICOLA - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>FEMS yeast research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tasaki, Sonoko</au><au>Cho, Tamaki</au><au>Nagao, Jun-Ichi</au><au>Ikezaki, Shojiro</au><au>Narita, Yuka</au><au>Arita-Morioka, Ken-Ichi</au><au>Yasumatsu, Kanae</au><au>Toyoda, Keita</au><au>Kojima, Hiroshi</au><au>Tanaka, Yoshihiko</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Th17 cells differentiated with mycelial membranes of Candida albicans prevent oral candidiasis</atitle><jtitle>FEMS yeast research</jtitle><addtitle>FEMS Yeast Res</addtitle><date>2018-05-01</date><risdate>2018</risdate><volume>18</volume><issue>3</issue><spage>1</spage><pages>1-</pages><issn>1567-1364</issn><issn>1567-1356</issn><eissn>1567-1364</eissn><abstract>Candida albicans is a human commensal that causes opportunistic infections. Th17 cells provide resistance against mucosal infection with C. albicans; however, the T cell antigens remain little known. Our final goal is to find effective T cell antigens of C. albicans that are responsible for immunotherapy against candidiasis. Here, we prepared fractions including cytosol, membrane and cell wall from yeast and mycelial cells. Proteins derived from a membrane fraction of mycelial cells effectively induced differentiation of CD4+ T cells into IL-17A-producing Th17 cells. To confirm the immunological response in vivo of proteins from mycelial membrane, we performed adoptive transfer experiments using ex vivo stimulated CD4+ T cells from IL-17A-GFP reporter mice. Mycelial membrane-differentiated CD4+ Th17 cells adoptively transferred intravenously prevented oral candidiasis by oral infection of C. albicans, compared with control anti-CD3-stimulated CD4+ T cells. This was confirmed by the clinical score and the number of neutrophils on the infected tissues. These data suggest that effective T cell antigens against candidiasis could be present in the membrane protein fraction of mycelial cells. The design of novel vaccination strategies against candidiasis will be our next step.</abstract><cop>England</cop><pub>Oxford University Press</pub><pmid>29462298</pmid><doi>10.1093/femsyr/foy018</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1567-1364 |
| ispartof | FEMS yeast research, 2018-05, Vol.18 (3), p.1 |
| issn | 1567-1364 1567-1356 1567-1364 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6019029 |
| source | Oxford Journals Open Access Collection; MEDLINE; PubMed Central |
| subjects | Adoptive Transfer Animals Antifungal agents Antigens Antigens, Fungal - immunology Antigens, Fungal - pharmacology Candida albicans Candida albicans - immunology Candidiasis Candidiasis, Oral - immunology Candidiasis, Oral - prevention & control CD3 antigen CD4 antigen CD4-positive T-lymphocytes Cell Differentiation Cell walls Cytosol Female Fungal Proteins - immunology Fungal Proteins - pharmacology Health aspects Helper cells immune response Immunotherapy Infection intravenous injection Leukocytes (neutrophilic) Lymphocytes Lymphocytes T Male Membrane proteins Mice Mice, Inbred C57BL Mucosa Mycelia mycelium Mycelium - chemistry Mycelium - immunology neutrophils Oral infection Prevention Proteins secondary infection T cells Th17 Cells - cytology Th17 Cells - immunology Thrush (Mouth disease) tissues Vaccination yeasts |
| title | Th17 cells differentiated with mycelial membranes of Candida albicans prevent oral candidiasis |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-11T04%3A23%3A16IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Th17%20cells%20differentiated%20with%20mycelial%20membranes%20of%20Candida%20albicans%20prevent%20oral%20candidiasis&rft.jtitle=FEMS%20yeast%20research&rft.au=Tasaki,%20Sonoko&rft.date=2018-05-01&rft.volume=18&rft.issue=3&rft.spage=1&rft.pages=1-&rft.issn=1567-1364&rft.eissn=1567-1364&rft_id=info:doi/10.1093/femsyr/foy018&rft_dat=%3Cgale_pubme%3EA702388028%3C/gale_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2400003476&rft_id=info:pmid/29462298&rft_galeid=A702388028&rfr_iscdi=true |