Granzyme B is elevated in autoimmune blistering diseases and cleaves key anchoring proteins of the dermal-epidermal junction

In healthy skin, epidermis and dermis are anchored together at the dermal-epidermal junction (DEJ), a specialized basement membrane pivotal for skin integrity and function. However, increased inflammation in the DEJ is associated with the disruption and separation of this junction and sub-epidermal...

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Veröffentlicht in:	Scientific reports 2018-06, Vol.8 (1), p.9690-11, Article 9690
Hauptverfasser:	Russo, Valerio, Klein, Theo, Lim, Darielle J., Solis, Nestor, Machado, Yoan, Hiroyasu, Sho, Nabai, Layla, Shen, Yue, Zeglinski, Matthew R., Zhao, Hongyan, Oram, Cameron P., Lennox, Peter A., Van Laeken, Nancy, Carr, Nick J., Crawford, Richard I., Franzke, Claus-Werner, Overall, Christopher M., Granville, David J.
Format:	Artikel
Sprache:	eng
Schlagworte:	13/51 631/1647/2067 631/80/474 692/1807/1812 692/699/249/1313 692/699/4033 82/29 82/58 82/81 Autoantigens - metabolism Bullous pemphigoid Collagen Collagen Type XVII Dermatitis Dermatitis herpetiformis Dermatitis Herpetiformis - metabolism Dermis Dermis - metabolism Epidermis Epidermis - metabolism Epidermolysis bullosa Epidermolysis bullosa acquisita Granzyme B Granzymes - metabolism Humanities and Social Sciences Humans Immunohistochemistry In Vitro Techniques Inflammation Mass spectrometry Mass spectroscopy multidisciplinary Non-Fibrillar Collagens - metabolism Pemphigoid, Bullous - metabolism Proteolysis Science Science (multidisciplinary) Serine Serine proteinase Skin Skin - metabolism Skin diseases Tandem Mass Spectrometry
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